Lab of Dr. Nephi Stella, University of Washington

The lab of Dr. Nephi Stella studies the molecular mechanism and therapeutic value of cannabinoid-based molecules.

[Marijuana Moment @MarijuanaMoment]

Massachusetts Senate Passes Bill To Let Military Veterans Get Medical Marijuana Without A Doctor's Recommendation: The legislation would also add PTSD, chronic pain and opioid use disorder as medical cannabis qualifying conditions.
https://t.co/DmnBzrd70w

[Neuropsychopharmacology @npp_journal]

Why do some cannabis users never develop addiction while 1/10 progress to cannabis use disorder? A new genetic study reveals that cannabis use vs use disorder are wired differently: distinct brain networks, genes, and biology

https://t.co/DqltqIpNJI

[Marijuana Moment @MarijuanaMoment]

Doubling The Amount Of THC In Marijuana Doesn't Get You Twice As High, New Study Shows (Op-Ed): "The high rises quickly at low doses, but extra THC soon adds less and less, which backs the advice to start low and go slow."
https://t.co/JBgu9BsQIN

[Neuropsychopharmacology @npp_journal]

How does THC affect emotion regulation in PTSD?

THC produced dose-related reductions in prefrontal engagement during negative emotion reappraisal, suggesting a role for cannabinoids in re-engaging efficient emotion regulation strategies in PTSD

https://t.co/1nY0IqKvtS

[BryanRoth @zenbrainest]

"These data do not strongly support the use of a single exposure to psychedelics in the treatment of OUD but may suggest persistent effects of psychedelics on heightened pain perception typically observed in opioid withdrawal."
#psychedelics
https://t.co/rukckTqJ6b

[Bertoglio lab (FMC/UFSC) @bertogliolab]

A preliminary pharmacodynamic overview of objective measures of intoxication in regular and fast-acting cannabis edibles
https://t.co/OCsiGnrto9

[Bertoglio lab (FMC/UFSC) @bertogliolab]

5-HT2A receptor activation induces CB1-dependent presynaptic inhibitory long-term depression in the nucleus accumbens core
https://t.co/EC1Qmk69PV

[Bertoglio lab (FMC/UFSC) @bertogliolab]

Cannabidiol attenuates behavioral impairments and deficits in parvalbumin interneurons and their perineuronal nets induced by adolescent stress in adult mice
https://t.co/jiTHAqsAXs

[Bertoglio lab (FMC/UFSC) @bertogliolab]

Acute Ultra Low Dose THC Attenuates Anxiety-Like Behavior in a Mouse Model for Major-Depressive Disorder
https://t.co/5PhBwaNPYX

[Jibran Khokhar @DrJKhokhar]

So excited to finally share this collaborative work exploring the role of CADM2 recursive splice site deletions led by @Philip_M_Boone. We (@JKhokharLab) were fortunate to characterize the neural and behavioural consequences of CADM2 RS1 deletion https://t.co/dTc9E5sZgR

[BryanRoth @zenbrainest]

This is, frankly, an amazing study. Given ongoing human trials this, I think, provides context,
Stepwise engagement of cingulate ensembles underlies motivational decline in chronic pain: Neuron https://t.co/TXC5cDrFnN

[Oded Rechavi @OdedRechavi]

Prediction: no one will care about journal names in 5 years.

[Bertoglio lab (FMC/UFSC) @bertogliolab]

Cannabinoid modulation of central amygdala population dynamics during threat investigation
https://t.co/UWv3QL2dkb

[Cannabis and Cannabinoid Research Journal @CannabisJrnl]

🐭 Low-THC, CBD-rich hemp oil boosted sociability in mice — no sedation, no side effects. An early lead for conditions like autism.

https://t.co/rKgHwRVCEb

[Center for Medicinal Cannabis Research (CMCR) @cmcr_ucsd]

📢 New Study: Cannabis use patterns in cannabinoid hyperemesis syndrome (CHS) 🤢
🔹 Survey of 1,134 respondents
🔹 96.5% used cannabis at least daily; 45% used ≥6 times/day near symptom onset
🔹 Morning nausea & stomach pain were common early symptoms
⚠️ Self-reported observational survey; causality cannot be inferred
➡️ Patterns may support earlier CHS recognition
🔗 https://t.co/0gyoHwOiRp
#MedicalCannabis #CannabisResearch #CannabisEducation #CHS #HarmReduction

[Joao P. De Aquino, M.D. @JPDeAquinoMD]

🚨 We're hiring!

The @PainLaboratory at @YalePsych is recruiting a #postdoc in #pain & #addiction neuropsychopharmacology.

Human lab studies of #cannabinoids & #psychedelics:
pharmacokinetics/pharmacodynamics, psychophysics, clinical trials. PhD/MD.

https://t.co/jNBR4Di1zf

[Sue Biggins @SueBiggins]

@HutchBasicSci is searching for an associate or senior faculty member! Generous package thanks to donation from Bezos family:https://t.co/Eqo4fqhK8N. Come join us in Basic Sciences

[Lab of Dr. Nephi Stella, University of Washington @StellaLab11]

@NathanielEDavid @zenbrainest New approach in Drug discovery: very cool that they targeted CB2R. Check it out!

[Nathaniel David @NathanielEDavid]

Someone finally ran the control experiment that drug discovery has been skipping for the last fifty years, and the result is going to to make your weekly med chem meetings kind of awkward :)

https://t.co/EeYL8QCpdx

[Bertoglio lab (FMC/UFSC) @bertogliolab]

Anandamide blocks spatial memory reconsolidation in male rats through a CB1 receptor dependent mechanism
https://t.co/D3ml7XEAcW