Stem Pharm, Inc.

Redefining neurological drug discovery

Check out our latest paper:

[Stem Pharm, Inc. @stempharm]

Graphical abstract summarizing the paper

[Stem Pharm, Inc. @stempharm]

🚨 New publication! 🚨

We're excited to share our latest paper in Cells:
Stimulus-Based ApoE Alzheimer's Disease Induction Model Using Microglia-Containing Brain Organoids for Drug Discovery.

📄 https://t.co/P9Iakcbh0J

🧵👇

[Stem Pharm, Inc. @stempharm]

As the NIH and FDA continue advancing human-based New Approach Methodologies (#NAMs), we're excited to contribute models that better capture human biology and help accelerate development of new therapies for Alzheimer's disease.

#Alzheimers #BrainOrganoids #Neuroinflammation

[Stem Pharm, Inc. @stempharm]

New in J. Neuro-Oncology: our collaboration with @mahua_deyMD shows that our neuroimmune organoids can model diffuse midline glioma biology, capture patient tumor complexity, and enable cell-type-specific toxicity testing. https://t.co/2XEwEU9gwM
#NeuroOncology #DMG #Organoids

[Stem Pharm, Inc. @stempharm]

@InMedPharma announced positive data from human brain organoid neuroinflammation models supporting their INM-901 Alzheimer’s disease program, generated from Stem Pharm’s human 3D neuro-immune organoid platform. Full release: https://t.co/4KRgtLDXKz

[Stem Pharm, Inc. @stempharm]

Madison is buzzing with investor events this week.

11/5–11/6: Wisconsin Early Stage Symposium (Monona Terrace) https://t.co/ami0DudSkm
11/6: +Venture Health by NVNG (Element Labs) https://t.co/df5fwyACwN

We'll attend both. DM to meet.
#MadisonWI #biotech #venturecapital

[Stem Pharm, Inc. @stempharm]

Stem Pharm is heading to Neuroscience 2025 (San Diego, Nov 15–19). We are eager to connect on neuroimmunology across AD, other neurodegenerative disorders, epilepsy, and brain cancers.
▶️ Contact us to schedule a meeting. https://t.co/PjTP0jn9IB #SfN25

[Stem Pharm, Inc. @stempharm]

Big thanks to the Center for Technology Commercialization, Wisconsin Economic Development Corporation, & Wisconsin SBDC for the opportunity to share our work and connect with Wisconsin innovators.

#SBIR #Innovation #Biotech

[Stem Pharm, Inc. @stempharm]

Bottom line:
✅ Human-relevant
✅ Mechanistic insight
✅ Scalable for screening
This is a leap forward for DNT testing and neuroinflammation research.
#NAMs #organoids #DNT #neurotox #neuroinflammation #toxicology #drugdiscovery #microglia #SBIR #NIH #FDA

[Stem Pharm, Inc. @stempharm]

🚨 New publication alert! 🚨
We’ve developed human neural organoids with microglia to model how environmental toxins cause neuroinflammation and developmental neurotoxicity (DNT).
📄 https://t.co/XIXB4ICjQg

[Stem Pharm, Inc. @stempharm]

With the @NIH and @US_FDA actively supporting human New Approach Methodologies (NAMs), this work underscores how organoid models can improve toxicity screening AND accelerate drug discovery.

[Stem Pharm, Inc. @stempharm]

This research was made possible by SBIR support from @NIH_NIEHS and @NIHAging — thank you for backing science that matters! 🙏

[Stem Pharm, Inc. @stempharm]

One standout finding: lead exposure triggers a distinct neuroinflammatory response. Our platform revealed pathway-level disruptions and microglia-specific signatures of toxicity. 🧠⚠️

[Stem Pharm, Inc. @stempharm]

Our study shows that microglia are key mediators of toxicant-induced responses in the brain. Using transcriptomics, cytokines, and biomarkers, we saw cell-specific and time-dependent effects from known developmental neurotoxins.

[Stem Pharm, Inc. @stempharm]

🧠 Today is #GBMDay — a time to honor lives impacted by glioblastoma and stand with those fighting for better treatments.

At Stem Pharm, we're advancing new methods to model the GBM tumor environment and accelerate drug discovery. We’re proud to be part of the fight.

[Stem Pharm, Inc. @stempharm]

New pod drop! 🎙️ Stem Pharm CEO Steve Visuri talks with Open Record about replacing animal tests with our 3D human neural organoids—hot on the heels of FOX6 Milwaukee’s story. Listen → https://t.co/jdrMzHi0UR (https://t.co/jdrMzHi0UR)
#3Rs #biotech #organoids

[Stem Pharm, Inc. @stempharm]

We’re on @fox6now! 🧠 Stem Pharm’s brain organoids are powering the future of drug discovery—especially in Alzheimer’s disease. Thank you @BryanPolcyn for sharing our story!
Watch here: https://t.co/QX77vX6rw5
#StemPharm #BrainOrganoids #Alzheimers #DrugDiscovery #Biotech