Steve Miner

Interventional Cardiologist, Southlake Regional Health Centre

[Iñigo San Millán @doctorinigo]

Thank you @Brady_H for echoing our latest study! 🙏

[Iñigo San Millán @doctorinigo]

🚨 🔬RIGHT OUT OF THE OVEN!. Our last study published today!.

Even in apparently healthy people, sedentarism was associated with a major impairment in mitochondrial function.

We used skeletal muscle biopsies, high-resolution mitochondrial respirometry, metabolomics, proteomics, targeted mitochondrial lipidomics including cardiolipin analysis, ROS assessment and ¹³C tracer-based oxidation flux analyses to examine how sedentarism affects mitochondrial function, substrate oxidation and cellular fuel metabolism.

1) One of the key findings was an almost 50% reduction in MPC1 (the mitochondrial pyruvate carrier) that allows pyruvate to enter the mitochondria and be oxidized.

Our data suggests that glucose dysregulation could happen at the mitochondrial level, years before insulin resistance happens at the surface level, leading to type 2 diabetes. I call this an "inside-out" theory of glucose dysregulation.

2) The second important finding is that we can also correlate the mitochondrial dysfunction, metabolic flexibility and decrease in MPC1 with cardiopulmonary exercise testing (CPET) plus lactate testing, which I call "CPELT" -cardiopulmonary exercise lactate testing. With this test we could indirectly assess in a non-invasive way, mitochondrial dysfunction in healthy people years before metabolic disease shows up and intervene with specific exercise prescription and nutrition.

Link to the study here!👇
https://t.co/338KE6plE5

#Mitochondria #MetabolicHealth #PhysicalActivity #Sedentarism #MPC1 #Metabolism #Healthspan #Longevity #DiabetesPrevention #HealthyAging

[Shruti @heyshrutimishra]

Elon just created 4,400 millionaires in a single day.

400 of them are now worth over $100 million.

These aren't VCs. They're SpaceX employees, and the list includes welders, technicians, and cafeteria staff, because for two decades the company paid every level of the workforce in stock instead of higher salaries.

Juan Hernandez immigrated from Mexico and took a $28 an hour contractor welding job in 2015. He says he didn't even know what SpaceX was. The company gave him a $10,000 equity grant and let him buy more shares through payroll deductions. That stake is now worth $880,000.

Trevor Hise's parents wanted him to take a stable job at General Electric. He picked SpaceX instead, stayed 12 years, and accumulated over 100,000 shares. At the $135 listing price that's $13.5 million. He's 37 and semiretired. His words: "The magnitude of this has been ridiculous."

The most telling detail came before the listing. Over 100 employees quietly banded together and negotiated a group wealth management deal covering up to $5 billion, because none of them had ever needed a wealth manager before.

Software IPOs have minted millionaires for 30 years. This is the first one where the money went to the factory floor.

[Kayla Barnes-Lentz @femalelongevity]

The myth that women don't get chest pain is wrong.

In the VIRGO study, 87% of women under 55 having a heart attack reported chest pain.

The real difference: women often have 3+ added symptoms too (jaw, neck, back, arm pain, breathlessness, profound fatigue).

[Christopher Perry PhD @ChrisPerryMito]

Congratulations, Joel!

[Mona Tirén @monaltiren]

@DrAllenJ @rallamee @wfearonmd @MGtberg @MortonKern @SteveMiner1967 @JEscaned @BinitaShahMD @nadia_sutton @ron_waksman @JWMoses @hect2701 @ESHLOF @DrAmirKaki #CoronaryPhysiology
#OPCINY26

#AngioDerivedPhysiology

For assessing the coronary
MICROCIRCULATION
🤔

@SteveMiner1967
@rallamee
@MGtberg
@ESHLOF
@JEscaned
@nadia_sutton
@OlgaTolevaMD

[Serena Caglioni @Serena_Caglioni]

It was a great honor to present the primary results of the SAMCRO trial at #EuroPCR2026 as #LBCT
➡️multidomain lifestyle intervention in ANOCA
🎯significantly reduces angina
🎯and improves health-related quality of life
Thanks to my mentors 💪🏻@GianlucaCampo78 @SimoneBiscaglia

[Mona Tirén @monaltiren]

@AdrianJeronimoB @escaned @ColinBerryMD @OlgaTolevaMD @AlexandraLansky @RoccoMontone @drTPH #CoronaryPhysiology
#EuroPCR2026

+SPECT
-CCTA
+persistent symptoms ❗️
🤔

INOCA
📍242AB

👋
@AdrianJeronimoB
@JEscaned
@ColinBerryMD
@OlgaTolevaMD
@AlexandraLansky
@RoccoMontone
@drTPH

[Laurie-Anne Boivin-Proulx @ProulxBoivin_LA]

⚡️ In this case series, we found that nebivolol may be helpful in patients with refractory epicardial vasospasm presenting with recurrent ventricular tachycardia.

@SteveMiner1967

https://t.co/Mv1T7UHwQI

[Steven Pinker @sapinker]

I spoke with @LaulPatricia about Marxism:

One is: What’s remarkable is that Marxism has been tried. Now, of course, defenders of Marxism say it hasn’t really been tried anywhere, but certainly the people who implemented it claimed they were implementing Marxism.

And this is a massive experiment—a global experiment—with a very clear outcome. Namely, the Soviet Union was a disaster. The imposition of communism on Eastern Europe was a disaster. The imposition of communism in Venezuela was a disaster. The imposition of communism in Maoist China was a disaster. Disaster in terms of both poverty and oppression and genocide and stupid wars. So the world has told us what happens under communism, and it’s a sign of how out of touch intellectuals can be that there are still people who defend it despite the entire world giving a very clear-cut answer.

One more is: would you rather live in North Korea or South Korea? Would you rather live in the old East Germany or West Germany? We have an experimental group and a matched control group in terms of culture, language, and geography, and the answer is crystal clear. So this is a sign of, I think, the pathology of intellectual life—that Marxism can persist.

The other is, you did call attention to one of the appeals of Marxism, though, and more generally of heavy, strong influence of government guided by intellectuals, which is that there are certain kinds of reforms that you can state as principles. You can articulate them verbally as propositions—like equality, human rights, democracy—but there’s other kinds of progress that take place in massive distributed networks of millions of people, none of whom implements some policy. But collectively, there is an order, an organization that’s beneficial.

So that can happen organically through, for example, the development of a language. No one designed the English language. It’s just hundreds of millions of English speakers. They coin new words. They forget old words. They try to make themselves clear. And we get the English language and the other 5,000 languages spoken on earth.

Likewise, a market economy is something where knowledge is distributed. You don’t have a central planner deciding how many shoes of size 8 will be needed in a particular city, but rather information is conveyed by prices, which are adjusted according to supply and demand. And you’ve got a distributed network of exchange of information that can result in an emergent benefit.

Now, intellectuals tend to hate that. They like rules of language—of correct grammar. They like top-down economic planning. They like cultural change that satisfies particular ideals described by intellectuals. And so rival sources of organization, like commerce, like culture—traditional culture—tend to be downplayed by intellectuals.

And this can be magnified by the fact that many dictatorships give a privileged role to intellectuals, which may be why, over the course of the 20th century, and probably continuing to the present, there has not been a dictator that has not had fans among intellectuals—including the mullahs and ayatollahs of Iran, but also the communist dictators: Mao and Castro, even Stalin in his day. And every other dictator has had, actually, often fawning praise from Western intellectuals.

[Phil Hoyeck @PAHoyeck]

"Socrates, right at the beginning of philosophy, got it going by saying that you mustn't discuss important and puzzling questions without studying the concepts in which they're posed."

—R.M. Hare on philosophical methodology

[Steve Miner @SteveMiner1967]

@TheSkeptic4122 This post is profoundly anti-scientific

[Mark_Sisson @Mark_Sisson]

Killed ten, saved zero

[Steve Miner @SteveMiner1967]

@KrutikaKuppalli https://t.co/xHFTSCvrPh

[Steve Miner @SteveMiner1967]

@Rainmaker1973 Flavour

[European Society of Cardiology Journals @ESC_Journals]

A new paper in #EHJ redefines endotypes of angina with non-obstructive coronary arteries. Read the results of prospective multicentre study 👉 https://t.co/8soSNZkPXb

@RoccoMontone @ehj_ed

[Steven Pinker @sapinker]

Bjorn Lomborg, an early survivor of 21st century cancel culture, has long raised vital questions. Rather than disputing his logic or conclusions (which he would be the first to admit could be wrong), academics & activists tried to demonize & silence him, a trend that grew. @Marian_L_Tupy recounts the history. https://t.co/cjVfAENlYo

[Steve Miner @SteveMiner1967]

@_ClimateCraze @cooljamm55 @russ_nicol Is this published in a peer-reviewed journal?

If not, is there open source data to independently validate these claims?

As a society we need to get away from unsubstantiated ideological claims

[Colin Berry @ColinBerryMD]

Microvascular angina is under diagnosed by coronary angiography. MRI improves diagnosing angina, symptoms and quality of life. 🙏 All credit to the participants and staff who supported the @TheBHF CorCMR trial https://t.co/5WUXPA5ixw @JubileeHospital @UofGlasgow @UofGMVLS

[EHJ Editor-in-Chief @ehj_ed]

EHJ issue 46 - 42 is online:

https://t.co/DtxWyk9WJP

Learn about game-changing trials in primary prevention, ischaemic heart disease, atrial fibrillation, and obstructive sleep apnoea

@escardio @ESC_Journals #EHJ #cardiotwitter