Thrilled to share that my work is out in @Nature. Here, we introduce Peptide Predictor, a tool for identifying new bioactive peptides. Using this method, we discovered BRP, an anti-obesity peptide. Huge thanks to the @SvenssonLab and all our collaborators! https://t.co/WfWMFDwVsR
The outer ear is a mammalian innovation but where did it come from? In our study in @Nature, @MathiThiru95 and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. https://t.co/i05me2SXI4
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Our new paper, "NK2R control of energy expenditure and feeding to treat metabolic diseases," is out today in @Nature.
Here we identify a single receptor that can both peripherally increase energy expenditure and centrally suppress appetite.
https://t.co/6Q8nG7wFOs
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Our latest out today @Nature!
We revisit a century-old theory and show that metabolic gradients work hand-in-hand with genetic&signalling instructions to shape the embryo. Glucose isn't just an energy source, it acts as a major conductor of the body plan🍬
https://t.co/mfx6Hk7nma
Drugs like Ozempic are great for weight loss, but they make some people feel sick. We discovered that the brain circuits mediating the appetite suppression are distinct from those that mediate nausea – a finding that may be leveraged to develop more selective GLP1-based drugs.
We thought there wasn't much new to learn about the cell cycle. Turns out we were wrong! Our paper (out today @Nature) identifies a novel alternative cell cycle that regulates differentiation, not cell division. https://t.co/ayDhJtKK6U. 1/10
In @Nature today, we reported that adhesive implant-tissue interfaces can prevent the formation of observable fibrous capsules on various organs, including the abdominal wall, colon, stomach, lung and heart, in diverse animal models, including rats, mice, humanized mice and pigs.
https://t.co/il2b9IUjFi
🎉 Drumroll, please! Meet the 2024 #PDSoros Fellows!
🗽 Selected from 2,300+ applicants, these 30 exceptional graduate students are changing the game in their respective fields. Click the link to get to know these trailblazers! #ImmigrantExcellence 🎓🎉
https://t.co/xuEgziTmwc
#MysterySolved! Krönke &co show @Nature that glucocorticoids are anti-inflammatory not in a transcriptional manner (🤯), but by boosting the Krebs cycle in macrophages, driving excessive #itaconate that interferes with pro-inflammatory cytokine induction! https://t.co/P96x4kzbbe
Excited to share our latest work revealing the requirements of pyrimidine nucleotides in the control of glucose oxidation and lipogenesis published in @ScienceMagazine. Huge congratulations to co-first authors Umakant Sahu and @VillaElodie! https://t.co/33FqVtSuiw
I am excited to share our preprint: “A torpor-like state in mice (TLS) slows blood epigenetic aging and prolongs healthspan”. Congratulations to @LornaLJayne and big thanks to our collaborators @prof_horvath, @bloodgenes, @VadimGladyshev and others.
https://t.co/vUyAK8OVJH
Very excited to share our recent discovery of a novel taurine metabolism pathway! We identified the orphan enzyme PTER as the predominant taurine N-acetyltransferase/hydrolase that regulates energy balance @longlabstanford
https://t.co/MBc6279LFP