Substratide

your one-stop shop for production-grade peptides, priced without markups, in Europe.

[Substratide @Substratide]

We didn't set out to build a peptide company.

We set out to source compounds for our own research - and hit a wall that anyone working in this space will recognise immediately 👇🧵

[Substratide @Substratide]

@peptidepirate glute fat!

[Substratide @Substratide]

@biohacker earlier sleep, caffeine, GHK-Cu.

[Substratide @Substratide]

@TheShreddington magnesium glycinate and progesterone may be effective remedies.

[Substratide @Substratide]

@pepfessions cyproheptadine fixes this.

[Substratide @Substratide]

@fitcapbiohacker pretty straightforward, DSIP and Pinealon.

[Substratide @Substratide]

@HealthPharaoh MT-1 is generally considered safer (and also an approved drug in much of the EU), but MT-2 has broader effects. Worth considering what your goals are? Reviving libido or just tanning?

[Substratide @Substratide]

Neither drug is "better" universally.
For a metabolically healthy researcher running a lean optimisation protocol: Tirzepatide's risk profile is cleaner and the efficacy is more than sufficient.

For severe obesity where every percentage point of weight loss reduces cardiovascular mortality: Retatrutide's upside may justify the tradeoff.

Context determines the answer.

[Substratide @Substratide]

Since Reta/Tirze have both stirred up controversy recently, we wanted to give a short overview of potential issues in comparing both.

First of all, they are both Eli Lilly compounds. Both produce extraordinary weight loss. Both are GLP-1 agonists at their core.

But they are not the same drug at all, and from a bioenergetic standpoint, the difference matters more than most people realise. 🧵👇

[Substratide @Substratide]

Retatrutide likely produces more weight loss, particularly at high doses or in heavier patients where the glucagon-mediated energy expenditure adds meaningful incremental benefit.

But you're trading that extra ~4–6% body weight loss for chronic glucagon receptor activation, accelerated amino acid catabolism, disrupted sleep architecture, and long-term unknowns that Phase 2 trials simply can't capture.

[Substratide @Substratide]

@doctormorphh @anabology vitamin C is capable doing the same thing

[Substratide @Substratide]

to expand on this, when fat intake is low and carbohydrate intake is high, the body is perfectly capable of increasing its consumption of carbohydrates as fuel, for example by uncoupling, or mitochondrial biogenesis, or by simply adding to one‘s ATP stores through regular oxidation of said carbs.

[Substratide @Substratide]

Since de-novo lipogenesis from carbohydrates only occurs at above 600g-700g of carbs daily (!), it may be useful to keep carb intake high while taking Retatrutide, so as not to lower one‘s basal metabolic rate.

[Marlon @drmarlonperalta]

I lost 20 lbs on retatrutide eating 1300 cal/day.

But it left me in low-calorie hell.
- Maintenance at 1500 cals
- Hungry and getting fat at 1900
- Metabolism broke

Then I figured out the 6 things most operators on a GLP-1 get wrong:

1. They don't train their metabolism

[Substratide @Substratide]

@kalospepgod is this just bot bait lol

[Substratide @Substratide]

@drmarlonperalta correct on all points!