Sumit Shil

Looking for a postdoc position | Nucleic acids | G4, i-motif, triplex | LLPS | Peptide | IDR Proteins | Biochemistry | Cancer biology | Chemical biology

[Ichihashi Lab Komaba @KomabaLab]

この前卒業した宮地さんの最後の論文がでました。
In vitroでアミノ酸(A, L, S)の配置を色々変えた非標準遺伝暗号表を10種類作って、変異に対する頑強性を調べたところ、どれもあまり変わりませんでした。
https://t.co/O6FFAD87bz
プレスリリースもしました。
https://t.co/DTwHBwQji1

[Takashi Fukaya @FukayaLab]

New preprint alert! Together with Tetsuya Yamamoto at Hokkaido University, we propose a “polymer micelle” model of transcriptional bursting. https://t.co/tw2FMdpWuz

[Sumit Shil @SumitSh29905877]

#Nobel in Chemistry #MOF #Japan

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2025 #NobelPrize in Chemistry to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.”

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2025 #NobelPrize in Chemistry to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.”

[Sumit Shil @SumitSh29905877]

Nobel prize Physiology 2025

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

[J. Am. Chem. Soc. @J_A_C_S]

Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design | Journal of the American Chemical Society @NobelPrize https://t.co/s65E6TBS2M

[J. Am. Chem. Soc. @J_A_C_S]

Protein NMR Structures Refined with Rosetta Have Higher Accuracy Relative to Corresponding X-ray Crystal Structures | Journal of the American Chemical Society @NobelPrize https://t.co/WXcpJghZdB

[The Nobel Prize @NobelPrize]

The 2024 #NobelPrize laureates in chemistry Demis Hassabis and John Jumper have successfully utilised artificial intelligence to predict the structure of almost all known proteins.

In 2020, Hassabis and Jumper presented an AI model called AlphaFold2. With its help, they have been able to predict the structure of virtually all the 200 million proteins that researchers have identified. Since their breakthrough, AlphaFold2 has been used by more than two million people from 190 countries. Among a myriad of scientific applications, researchers can now better understand antibiotic resistance and create images of enzymes that can decompose plastic.

Read more about their story: https://t.co/nWxcZs6wqC

[J. Am. Chem. Soc. @J_A_C_S]

2.1 and 1.8 Å Average Cα RMSD Structure Predictions on Two Small Proteins, HP-36 and S15 | Journal of the American Chemical Society @NobelPrize https://t.co/G1tZVMSfic

[J. Am. Chem. Soc. @J_A_C_S]

De Novo Determination of Protein Backbone Structure from Residual Dipolar Couplings Using Rosetta | Journal of the American Chemical Society @NobelPrize https://t.co/4GxFvzBxSm

[The Nobel Prize @NobelPrize]

This year’s chemistry laureates Demis Hassabis and John Jumper have developed an AI model, AlphaFold2, to solve a 50-year-old problem: predicting proteins’ complex structures.

Check out two examples of protein structures determined using AlphaFold2. First up, a bacterial enzyme that causes antibiotic resistance. The structure is important for discovering ways of preventing antibiotic resistance.

Animation: ©Terezia Kovalova/The Royal Swedish Academy of Sciences

#NobelPrize

[Sumit Shil @SumitSh29905877]

#protein structure prediction #NobelPrize2024 #Chemistry

[The Nobel Prize @NobelPrize]

2024 #NobelPrize laureate in chemistry David Baker has succeeded with the almost impossible feat of building entirely new kinds of proteins.

In recent years, one incredible protein creation after the other has emerged from Baker’s laboratory. They range from new nanomaterials where up to 120 proteins spontaneously link together…

Animation: ©Terezia Kovalova/The Royal Swedish Academy of Sciences

#NobelPrize

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

[Sumit Shil @SumitSh29905877]

#Alpha fold, #NobelPrize2024 #Chemistry

[The Nobel Prize @NobelPrize]

In 2003, this year’s chemistry laureate David Baker succeeded in designing a new protein that was unlike any other protein. This was the first step in something that can only be described as an extraordinary development. A few of the many spectacular proteins created in Baker’s laboratory using his computer software Rosetta can be seen in the picture.

He also released the code for Rosetta, so a global research community has continued to develop the software, finding new areas of application.

Baker’s research group has produced one imaginative protein creation after another, including proteins that can be used as pharmaceuticals, vaccines, nanomaterials and tiny sensors.

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

[The Nobel Prize @NobelPrize]

2024 physics laureate Geoffrey Hinton used a network developed by his co-laureate John Hopfield as the foundation for a new network: the Boltzmann machine. This can learn to recognise characteristic elements in a given type of data.

The Boltzmann machine can be used to classify images or create new examples of the type of pattern on which it was trained. Hinton has built upon this work, helping initiate the current explosive development of machine learning.

#NobelPrize

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

[Sara N. Richter @SaraNRichter_]

We are back with the #G4 and beyond webinar series! Starting from June 1 we host 10 webinar days where exciting new science on non-canonical nucleic acids will be presented by 16 outstanding PIs and 8 excellent PhD students. Join us! @PaeschkeL @RichterLabUnipd

[Eric Topol @EricTopol]

Just published @Nature
New evidence from 70 years ago: Rosalind Franklin was a co-discoverer of DNA's double-helix structure
by @matthewcobb @nccomfort
https://t.co/MtGnD3mcVc

[Sandipan Brahma @BrahmaComplex]

Received NOA for R00, so lab is officially @NIH-funded! Seeking postdocs interested in the broad areas of chromatin dynamics and transcription regulation. Fully funded positions available immediately. DM/email ([email protected])/ apply now at https://t.co/shYrTtS9m3. Please RT