Public Health, Covid, climate change, Kashmir, Migration, World Health Network, #LongTB#PAST-TB #LivingScientificPaper Also at @SunilRaina15.bsky.social
TB is not a historical curiosity. It's a preview.
A pathogen that found the immune system's structural blind spots & refined a dormancy strategy when we introduced the tools meant to kill it.
The AMR crisis may be the new beginning. #AMR#Staph#herpes#TB#InfectiousDisease
Microbiology Thread
@microthread#TB#HIV#HerpesVirus
Why have we eradicated smallpox but can't touch TB — a disease we've had a vaccine for since 1921?
It comes down to one word: latency
& the story of how TB evolved is one of the most remarkable in all of biology.
S. aureus is already showing intracellular survival in macrophages & bone cells. Recurrent UTIs, implant infections, CF lung infections—these are persistent infections. The bacteria aren't being killed. They're waiting.
TB took 70,000 years to refine this. We may have decades.
#TB#AntibioticResistance#Covid
TB may not be a unique historical accident- but a preview
TB: Maybe the first pathogen to stumble on a winning long-term strategy, which other bacteria are now being inadvertently pushed toward by the very tools we created to fight them. @TheWHN
Sometimes, some research stays with you for life- It started 15 years back for us & continues to engage us even today India’s Silent Village Shows What Happens When Genetic Clusters Go Unaddressed | Global Health NOW https://t.co/XOwp0J80V0
🔴 Six years later, the true scale of the vaccines’ side effects is emerging. Yet those coping with life-changing conditions remain ignored
Read how Nikola was left disabled after receiving the AstraZeneca vaccine below 🔗
https://t.co/SJU5SwDLVz
It is more useful for humanity that everyone learns to ask the right question badly than that a few experts learn to answer the wrong question well @W01fGirl@LazarusLong13
TB's greatest evolutionary strength: phenotypic dormancy under hostile pressure
Our policy- mass antibiotic exposure, incomplete t/t, no reactivation biomarker, ongoing transmission.
We r designing the exact selective environment TB needed
R we selecting for a better TB?
#EndTB
#DRTB
I think most important is to expand the base- reach out to everyone & not just to high risk & to begin treating air as the Social Determinant of consequence in TB transmission @the_hindu https://t.co/HY67ATAgLj
10/10 "Relapse"—burden of explanation on the patient — their bacteria, adherence, immunity.
"Recurrent TB in an unchanged environment" puts it where it also belongs — on poverty, housing, ventilation & public health systems.
Words shape what we see & what we choose to fix
#TB
1/10Something about TB terminology has been bothering me for a while.
We call it "relapse" when a cured TB patient gets TB again.
But what if that word is quietly misleading us — and hiding a much bigger problem?
Let me explain. 👇 @TheWHN@Tuliodna@organicbotanic
9/10
What honest program design is ?
→ Active follow-up of cured patients, not just discharge → Aggressive household & community contact management → Treat the household as the unit of intervention, not just the individual → Measure transmission interruption, not just cure