Misfit

Stumbling around the esoteric and exoteric.
Using Twitter as a news feed... but (lately) mostly for crypto and AI art.

[Naomi Brockwell priv/acc @naomibrockwell]

30 years ago John Perry Barlow wrote the Declaration of the Independence of Cyberspace. But are we truly free in the digital age? In this video, I explore why it’s time for a new declaration to defend our privacy, autonomy, and digital freedom.

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. Everyone is sharing this study as a skin story. They're burying the part that matters.
Scientists took the aorta of a 75-year-old donor, applied a single engineered enzyme, and stripped away more than 70% of the molecular damage — bringing it down to the levels you'd see in a 30-year-old artery.
Published five days ago in Nature Communications. Revel Pharmaceuticals, with Calico and the University of Colorado.
Here's what they erased.
Sugar reacts with proteins in your body the same way heat browns bread — slowly, over a lifetime. It leaves behind a residue called CML, the most abundant advanced glycation end product in aging tissue. It welds itself onto collagen and elastin in your skin, your eye lens, and your arterial walls.
Two things follow. Your arteries stiffen. And CML latches onto a receptor called RAGE, which drives chronic inflammation — the exact fire I've been writing about for months as the engine of heart disease.
Since the 1980s this damage was considered permanent. Your body has no enzyme to remove it. Every existing approach only slows new damage from forming. Nothing touched what was already there.
So they built an enzyme that doesn't exist in nature. They screened 45,000 protein structures, then ran five rounds of directed evolution across more than 500 million variants until they had CMLase — a molecular lawnmower that oxidizes the CML off the protein and restores the original, healthy lysine underneath.
Not patched. Reversed.
Over 70% cleared from elderly arterial tissue. Over 55% from elderly skin — below the levels found in 31-year-old skin. 45-78% in lens proteins. The CEO said they expected 20% and were floored.
Arterial stiffness drives systolic hypertension, heart failure, and stroke, and I have no drug that reverses it. I can slow the process. I cannot undo it. This paper says undoing it may be possible.
The caveats are real and I won't skip them. This was done on donated tissue in a dish, not in a living person. No functional data yet — we don't know if that artery got measurably more elastic. Delivering a large enzyme deep into human tissue is a hard, unsolved problem. Clinical trials are years away.
But something considered permanent for forty years just came off human tissue.
We spent a century learning to slow aging. Someone finally figured out how to erase it.
Thank you @theallinpod @friedberg @chamath @pesottas

[Naomi Brockwell priv/acc @naomibrockwell]

They shut down FISA 215 but expanded FISA 702 into a global surveillance dragnet. Congress keeps reauthorizing it.
Who actually consented to this?

[Misfit @SynapticMisfit]

@BillyM2k Yep

[Misfit @SynapticMisfit]

@coinbureau Does that count the second job holders?

[Naomi Brockwell priv/acc @naomibrockwell]

When one of the few senators with access to classified surveillance programs starts asking about VPNs, it’s worth paying attention.
Is the government running a dragnet on VPN users?

[John E Deaton @JohnEDeaton1]

Let me be clear:

FUCK THE BANKS.

Is there any better evidence of REGULATORY CAPTURE than what we are witnessing play out with Banks and the Clarity Act.

MA voters, ask yourself: Why would Wall Street Bankers prefer 80 year old @EdMarkey - who’s been in Washington for 50 years - over me?

Because he’s a puppet of Wall Street - just like when he bailed out the banks in 2008.

[Misfit @SynapticMisfit]

@anyatrades Damn, good call in $VEEE

[Simply Bitcoin @SimplyBitcoin]

CHRISTINE LAGARDE: "If there is an escape, that escape will be used."

She said that about Bitcoin, not crime. She meant people holding money the ECB can't scan, freeze, or inflate.

Sophi's take it as a warning is off. It's your signal to use it. 👇

[Crypto Tice @CryptoTice_]

BREAKING:

The EU is planning to require a passport to access the internet.

And they want to block VPNs to enforce it.

"The new age verification system cannot be bypassed via VPN."

Read that again.

A digital passport. For the internet.
Enforced by blocking the tools that protect your privacy.

This is what the trajectory looks like.
- Cash banned above €10,000.
- Bitcoin requires ID above €1,000.
- Privacy coins banned.
- MiCA eliminating 90% of crypto firms.

And now internet access tied to your identity.

With VPN circumvention specifically blocked.

Every layer of digital privacy.
Being dismantled one regulation at a time.

While America debates zero capital gains on Bitcoin.
Europe is building a system where every click, every transaction, every website visit.

Is tied to your passport.

This is not consumer protection.
This is digital authoritarianism.

And they're not hiding it anymore.

[Misfit @SynapticMisfit]

@Firelghtsfi Dude, just stop.

[Misfit @SynapticMisfit]

@NeriOxman Biopunk aesthetics. 👍

[Misfit @SynapticMisfit]

@UpholdInc 🇺🇸🎆

[єℓαιηє @elainesim28]

How will Ireland cope with this heatwave 😂

[Misfit @SynapticMisfit]

@InvestorJordan Isn't investing sometimes a gamble? 🤔

[Elon Musk @elonmusk]

This censorship law is a wolf in sheep’s clothing. The real goal is to enable the UK government to track everyone.

[Misfit @SynapticMisfit]

@V2Chenz @169Pi_ai Good call!

[Misfit @SynapticMisfit]

Ponzinomics...
https://t.co/JErjdhNgcU

[Misfit @SynapticMisfit]

@MarcosArrut 24/7, 365 AI researchers are coming.

My question, do you think big companies will be able to bottleneck (stifle, patent) results before we get to partake?