Szyzygy

Student of uncertainty, evidence, chronic illness, curiosity, and all things imperfect and perfectable. Attempting to live the 80/20 rule. MBA. MCAS. Novid.

[Szyzygy @Szyzygy2]

The beautiful thing about mast cell activation is that it's treatable.
"Mast cells play a crucial role in the peripheral inflammation as well as in neuroinflammation due to brain injuries, stress, depression, and PTSD."
https://t.co/34TzrY1Bjy.

[Szyzygy @Szyzygy2]

@Renmakesmusic Why not just treat mast cell disease?

[Szyzygy @Szyzygy2]

@PaulWhiteleyPhD Treatable at home.
"Mast cells in the brain can impact sleep by releasing chemicals like histamine and cytokines."
 https://t.co/kd2VTYQ9DI

[Szyzygy @Szyzygy2]

@PaulWhiteleyPhD Brain mast cells regulate sleep/wake and other behavioral phenotypes and that histamine from brain mast cells promotes wakefulness.https://t.co/uLRFnLSjl9

[Thinking Autism @TweetingAutism]

"a toddler...may be...diagnosed with #autism and their skills loss considered to be consistent with ‘autistic regression’ with no further investigation."

It's not normal for children to regress/lose skills. Research needed into WHY (underlying biology).
https://t.co/9eRblU6lpP

[Szyzygy @Szyzygy2]

https://t.co/TPZKNIsfkO

[Szyzygy @Szyzygy2]

@PaulWhiteleyPhD Treatable

"Although there is still much work to be done, it is now apparent that MCs play central roles in several aspects of IBD. These include regulation of epithelium permeability..."
https://t.co/kd2VTYQHtg

[TACA @TACAfoundation]

🦠Microbiota Dysbiosis in Autism and Microbiota Transplant Therapy with James B. Adams, PhD

⏺️ RECORDED VIRTUAL EDUCATION EVENT
🗓️ February 1-28, 2025
https://t.co/q2ihQRdhUW
📲🖥️TACA website
https://t.co/F0a8cN6d04

[Thinking Autism @TweetingAutism]

Severity of GI difficulties correlated to emotional and conduct problems, hyperactivity, peer problems.
"Our data emphasize the potential importance of GI difficulties for various areas of functioning of individuals with ASD."
#autism
https://t.co/bzLFVNqPFZ
via @PaulWhiteleyPhD

[katie wright @katiewr31413491]

Causal relationship between B vitamins and neuropsychiatric disorders: A systematic review and meta-analysis👍👍👍👍👍👍 Fascinating https://t.co/dbzM0ZPQLv

[katie wright @katiewr31413491]

Impact of Psychosocial and Neurodevelopmental Disorders on Pediatric Ulcerative Colitis: 💥💥💥💥 Extremely similar to kids with ASD /GI disease. It’s an all consuming condition affecting social, emotional & cognitive aspects of life. 💥💥💥💥💥 https://t.co/YA7uwmdyMD

[Eric Topol @EricTopol]

New @Nature
How #AI can play a pivotal role in future pandemic preparedness and mitigation, with caveats
https://t.co/hI4FW5A3MA by @MOUGK @UniofOxford and collaborators around the world

[Canary @TheCanaryUK]

'Chronically Ill - Chronically Ignored': a new documentary on ME/CFS

This investigative documentary is set to give voice to the #MEcfs community in a groundbreaking piece of work. @h_sharland spoke with @sibylle_berlin about her new film #LongCovid 👇
https://t.co/V5nZrBb7A8

[Fluoroquinolone Toxicity Study @FQ_100]

New German documentary on chronic fatigue syndrome/ME * with section on #fluoroquinolone damage ...

‘Chronically Ill – Chronically Ignored’: a new documentary on ME/CFS

One of the “biggest medical scandals of the 21st century” is about to be blown wide open to a new audience. This is because, for the first time, a major broadcasting channel – in Germany – will air the stories of people living with myalgic encephalomyelitis (ME/CFS) in a new groundbreaking feature-length programme. Investigative documentary Chronically Ill – Chronically Ignored is set to give voice to this too-long abandoned community, amidst the harrowing, and shameful history of patient neglect, abuse, and obtuse scientific obstinance.

(within this article)

In the documentary, Dahrendorf and the production team delved into one lesser talked about factor: antibiotics.
Dahrendorf herself lives with fluoroquinolone damage – or fluoroquinolone associated disability (FQAD). They’re a group of antibiotics that doctors prescribe to treat various bacterial infections. Crucially though, there have been numerous patient reports of harm from these – as Dahrendorf can obviously attest to herself. In a personal statement preluding the documentary’s release, she described how among the multitude of chronic illnesses she lives with, she has:
mitochondrial damage, nerve damage, partly triggered by toxic antibiotics such as fluoroquinolones and metronidzoles.
Before the documentary was even a vision on the horizon, Dahrendorf had been shocked to find many people affected by fluoroquinolones in Germany. Significantly, many were ME patients with a history of taking these antibiotics:
At some point that made me really suspicious. And then we decided to put that topic also in the film because there’s an overlap. It’s an overlap in the diagnosis because the doctors are not able to do really clear analysis of the patients, because if they would ask the patient what kind of antibiotics did you take in the past and the patient would say okay, I took fluoroquinolones, then you have a fluoroquinolone damage – also called fluoroquinolone associated disability.

Read the full article here - Reading Time: 16 mins read:

by Hannah Sharland, 17 February 2025, Chronically Ill – Chronically Ignored. The Canary. https://t.co/XTs2Q8jBCk

______________________________________________________
Info on fluoroquinolone class of antibiotics: https://t.co/G9NJIEKEij
Drug list: https://t.co/OKH2DOWix0
______________________________________________________
* Myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome (CFS), is a complex chronic illness that affects multiple systems in the body. Symptoms can vary in severity and may fluctuate over time. Below are the key symptoms:

Core Symptoms:

Post-exertional malaise (PEM) – Worsening of symptoms after physical, mental, or emotional exertion, which can last for days or weeks.
Unrefreshing sleep – Feeling exhausted even after a full night’s rest.
Cognitive impairment ("brain fog") – Difficulty with memory, concentration, and processing information.
Orthostatic intolerance – Dizziness, lightheadedness, or worsening symptoms when standing up due to issues with blood flow regulation.

Other Common Symptoms:

Severe, persistent fatigue – Not relieved by rest.
Muscle and joint pain – Often widespread and without clear inflammation.
Headaches – Often new or different from previous headaches.
Sore throat – Chronic or recurrent, sometimes with swollen lymph nodes.
Temperature dysregulation – Feeling unusually hot or cold without a fever.
Gastrointestinal issues – IBS-like symptoms (bloating, nausea, diarrhea, constipation).
Sensory sensitivity – Sensitivity to light, sound, and smells.
Immune dysfunction – Prone to infections or prolonged recovery time from illness.

Disclaimer: Fluoroquinolone Toxicity Study does not provide medical advice, and all articles and written content are intended for informational purposes only. We do our best to provide accurate information. Such information is not a substitute for professional medical advice, diagnosis or treatment. Supplements, treatments, and pharmaceutical effects can vary significantly among individuals, particularly in those affected by fluoroquinolone drugs, due to differences in individual responses to these medications.

[Szyzygy @Szyzygy2]

@Oddlyuk1 @PaulWhiteleyPhD Yes.

[Szyzygy @Szyzygy2]

Parents say son with autism was nonverbal until trying an off-label drug that treats chemo side effects https://t.co/I0eb1OCy9P… Folinic acid front-and-centre. Here's some science: https://t.co/xi5h1JqiBU & some more: https://t.co/EGf0PDrUKl https://t.co/zN5zSlwGPJ

[T. Ryan Gregory 🇨🇦 @TRyanGregory]

🧵

Just to recap what is happening, since public health has gone AWOL:

* This is the worst flu season in 15 years. Not just number of cases but number of *severe* cases.

1/

[Szyzygy @Szyzygy2]

@PaulWhiteleyPhD Mast cell activation can cause aggression, this makes it very treatable.

[Nick Norwitz MD PhD @nicknorwitz]

💪Urolithin A & Muscle Health - Interesting RCT 💪

1/6) This study enrolled 88 overweight adults, mean BMI ~29 kg/m2 , who were between the ages of 40 and 64 for a 4 month intervention where they were treated with one of two doses of urolithin A (500 mg or 1000 mg per day) or a placebo.

Strikingly, both doses of Urolithin A improved leg muscle strength by 10-12% as compared to baseline, and improved leg muscle strength as compared to placebo. (Link at the end)

#mitochondria #microbiome #urolithinA

[Harriet Carroll: Long Covid Scientific Consultancy @angryhacademic]

Fun fact: i previously showed you what a mast cell looks like: https://t.co/mReOOEqAyJ

But here is what it looks like in action:
https://t.co/Ld9HUGOqOn

[The Mast Cell Disease Society, Inc. OFFICIAL @MCDiseasesUnite]

Our very own Calla Mace from the TMS team is leading a survey on the rare disease diagnostic journey for young adults (18-34). Your voice can help shape research!

Take the survey: https://t.co/z722HnMowE
📩 Questions? Email Calla at [email protected].