Thomas Hart

Assistant Professor at @JohnsHopkinsMMI
Ticks and Tickborne diseases
Host-pathogen interactions
🏳️‍🌈

[Thomas Hart @TMHartBio]

@PD_ThePinSeeker @ScienceTM @JohnsHopkinsMMI Thanks for reading!

[Thomas Hart @TMHartBio]

Overall, this work lays the foundation for the rational design of anti-tick vaccines that induce tick resistance-without needing to get bitten.

[Thomas Hart @TMHartBio]

Happy to share our new paper in @ScienceTM from Yingjun Cui, Erol Fikrig and @aaronmring, where we built a yeast display library of 3,000+ I. scapularis proteins to profile antigens recognized by tick-resistant hosts, and developed a new anti-tick vaccine. https://t.co/AfseBxqAtF

[Thomas Hart @TMHartBio]

We found 199 tick antigens recognized by immune sera, including many proteins with histamine binding domains-key proteins secreted by ticks during feeding. Further, we developed a novel anti-tick vaccine of antigens from tick cement, and found this vaccine inhibited tick feeding.

[Thomas Hart @TMHartBio]

We're looking for a postdoc to join my group @JohnsHopkinsMMI investigating host-pathogen interactions in Lyme disease!
If interested, please email a cover letter, CV, and contact information for three references to me at [email protected].

[Thomas Hart @TMHartBio]

I'm excited to share that I will be starting as an assistant professor this September in the Lyme and Tickborne Diseases Research and Education Institute @JohnsHopkinsMMI @JohnsHopkinsSPH to study how Lyme Borrelia sense and adapt to the host environment https://t.co/jFnNnMV1ZR

[Thomas Hart @TMHartBio]

@Xiaotian_Tang18 Thank you, Xiaotian!

[Thomas Hart @TMHartBio]

I’m excited to share our story in @CellCellPress from @aaronmring, Erol Fikrig, Noah Palm, @CarlyonLab, and all the amazing collaborators! We used an interaction profiling system to map interactions between the human exoproteome and microbial pathogens. https://t.co/H7L08WY8XQ

[Thomas Hart @TMHartBio]

@c5486112 @CellCellPress Thank you! It was a fun project to work on!

[Thomas Hart @TMHartBio]

@arshukla @CellCellPress @aaronmring @CarlyonLab Thank you!!

[Thomas Hart @TMHartBio]

@ThePedraLab Thank you! It’s been great working with you and your group on this.

[Thomas Hart @TMHartBio]

If this interests you, stay tuned as we’ve developed a similar library expressing extra cellular and secreted proteins of Ixodes scapularis, the vector of Lyme disease and other tickborne diseases!

[Thomas Hart @TMHartBio]

For example, we found epidermal growth factor influences transcriptional regulation of Lyme disease bacteria, Borrelia burgdorferi, and protein disulfide isomerases facilitate cell invasion for a range of Rickettsial pathogens.