Tom Snelling

Postdoc with Philip Cohen @mrcppu @dundeeuni with an interest in cell signalling and rare diseases!

[Tom Snelling @TWSnelling]

Excited to share our preprint reporting on the discovery of a new ALPK1 variant causing ROSAH syndrome in a family with 7 affected members! We also characterise this variant, showing its constitutive activity in cells #ROSAH #ALPK1 #mrcppu #UoDLifeSciences https://t.co/U1AmxSu9t8

[Trends in Biochemical Sciences @TrendsBiochem]

Available online - the Review "Diseases caused by altered specificity of a #proteinkinase for its allosteric activators" from Philip Cohen and @TWSnelling @mrcppu @dundeeuni.

#AtypicalAlphaKinase #ALPK1 #ROSAHsyndrom #Spiradenoma

https://t.co/M7mJWPFigd

[Bio-protocol @bioprotocolbyte]

Quantitative Measurement of the Kinase Activity of Wildtype ALPK1 and Disease-Causing ALPK1 Mutants Using Cell-Free Radiometric Phosphorylation Assays: https://t.co/2Qy8xgDjoT

Work by @TWSnelling at the @dundeeuni.

#Reproducibility #LifeSciences #Biochemistry

[Nature Biotechnology @NatureBiotech]

Multimodal scanning of genetic variants with base and prime editing https://t.co/S2poPOSxQR

[Ivan Đikić @iDikic2]

How #autophagy influences the regulation of MHC-I class receptors and regulates #immune evasion of #cancer?
A new role for an autophagy receptor IRGQ in this process with a clinical relevance for the development of liver carcinoma in humans and mice 😊😀

https://t.co/iH8YXDz0X9

[Matt Coelho @MatthewACoelho]

Now open – a CRUK-funded PhD clinical research training fellowship in my team at the Wellcome Sanger Institute.
https://t.co/WqMFlOObty

[𝐀𝐫𝐩𝐚𝐧 𝐌𝐞𝐡𝐭𝐚 @DrArpan100]

JOB ALERT! MND Accelerator Award funded postdoctoral position in my lab @mrcppu is now LIVE. We will use pooled CRISPR screening of iPSC motor neurons to identify new targets for ALS/MND.
To learn more & apply:
https://t.co/RtBtZMDSqe
Please help spread the word! Thank you.

[Tom Snelling @TWSnelling]

Happy to share two protocols describing how to study #ALPK1 disease-causing variants using cell-based and cell-free kinase assays! They were used in our recent preprint on #ROSAH syndrome. (https://t.co/dOvbRrLmke)
https://t.co/EVMO073mev
https://t.co/C0gp1RXOWv
#UoDLifeSciences

[Garnett Lab @Garnettlab]

Delighted to share our work in @NatureGenet using base editing to map genetic mechanisms of drug resistance. If you're interested in drug discovery then check it out. Access here https://t.co/ABubh1jm5F [https://t.co/7A7hMECNM3]. Congratulations to the team and @MatthewACoelho

[UoD Life Sciences @UoDLifeSciences]

Congrats to Celest Tay @taycell & Oliwia Mruk @olimruk who received Highly Commended Awards in the Life Science category of the Global @UndergradAward 2024. This was in recognition of their honours project research which both undertook @mrcppu

https://t.co/6MvrgOa7Fi

[Tom Snelling @TWSnelling]

@kesslet345 Thanks Abbie 😊

[Tom Snelling @TWSnelling]

Excited to share our preprint reporting on the discovery of a new ALPK1 variant causing ROSAH syndrome in a family with 7 affected members! We also characterise this variant, showing its constitutive activity in cells #ROSAH #ALPK1 #mrcppu #UoDLifeSciences https://t.co/U1AmxSu9t8

[Tom Snelling @TWSnelling]

@Dr_Ian_Kelsall Thanks Ian, hope you are doing well!

[Tom Snelling @TWSnelling]

@David_J_Adams Cool story!

[MRC PPU @mrcppu]

Congratulations Elisha and Catriona: Professor Sir Philip Cohen's 50th and 51st PhD students awarded their degress https://t.co/a6F2h2qgEV @elishamccrory_ @catriona_aitken

[Gopal Sapkota @gpsapkota]

An excellent postdoctoral opportunity to join @sapkota_mrcppu to work on WNT signalling and colorectal cancer. We are looking for someone with a with a strong background in cell and molecular biology. To apply: https://t.co/X9yL3NXAjd @mrcppu @UoDLifeSciences @dundeeuni

[Tom Snelling @TWSnelling]

@DrTomTORC @UoDLifeSciences @BiochemSoc @OyieJessica @mrcppu Thank you! 😀

[Biochemical Society @BiochemSoc]

Congratulations to @TWSnelling and @OyieJessica for receiving International Sponsored Places to attend the Biomolecular Horizons Congress 2024! We can't wait to hear about their experiences at this global forum celebrating the latest developments in bioscience and biotechnology.

[Sadaf Shadan @sshadan]

To restore cellular homeostasis, stress responses should be turned off at the right time and place. A paper @nature shows a ubiquitin-dependent mechanism through which unimported mitochondrial proteins silence the integrated stress response.

https://t.co/NwhSwRKw7i

[Tom Snelling @TWSnelling]

Thrilled to have been awarded the Howard Elder Prize for my work on ALPK1😃. This kinase is activated by bacterial ADP-heptose, but mutations that cause a genetic disease and a rare cancer allow it to also be activated by human metabolites! #ALPK1 @mrcppu
@UoDLifeSciences

[Rune Busk Damgaard @rbdamgaard]

📢 Are you interested in joining our lab in Copenhagen🇩🇰 as a #postdoc? We are an ambitious and friendly research group 👩‍🔬👨‍🔬 working on the regulation of #metabolism and #inflammation by #ubiquitin 🔬🧬. Project details and application link below👇 Please share!