Tain Luquez

PhD candidate @columbia studying the genomics of resilience to Alzheimer's. Previously at @isbsci under @ISBNathanPrice and @ISBLeeHood.

[Michael Wainberg @michaelwainberg]

Thrilled to share our work on the largest-ever genetic study of fibromyalgia! This was a massive international effort, and I'm very grateful to our 52 co-authors and the 2.5 million people who made this research possible.
https://t.co/jQ0mTYDa2n

[Veera Rajagopal  @doctorveera]

Link to this week's curation.
https://t.co/1V4yplNv0m

[nature @Nature]

Nature research paper: Cell-type signatures of Alzheimer’s disease shared across population groups

https://t.co/AJY8y3XesU

[Tain Luquez @TainLuquez]

@RNASeqBlog @ColumbiaMed Thank you for sharing our study! We hope this work contributes to a more complete understanding of Alzheimer’s disease by capturing molecular signatures across ancestries and cell types.

[Tain Luquez @TainLuquez]

@Nature Excited to share a short thread highlighting the key findings and story behind our study:
https://t.co/ARBspbjrMY

[Tain Luquez @TainLuquez]

We identified cell-type-specific Alzheimer’s disease signatures shared across ancestries, revealing conserved disease mechanisms that may improve the generalizability of biomarkers and therapeutic targets.
#Alzheimers #SingleCell #Neuroscience #Genomics

https://t.co/fdWPOqA9zJ

[Tain Luquez @TainLuquez]

A huge team effort by the amazing folks in Dr. Vilas Menon’s Lab at #ColumbiaUniversity. We are deeply grateful to all the donors and their families who made this work possible.

[Tain Luquez @TainLuquez]

We identified cell-type-specific Alzheimer’s disease signatures shared across ancestries, revealing conserved disease mechanisms that may improve the generalizability of biomarkers and therapeutic targets.
#Alzheimers #SingleCell #Neuroscience #Genomics

https://t.co/fdWPOqA9zJ

[Tain Luquez @TainLuquez]

5) Moving beyond uniform Alzheimer’s definitions, we identified six donor subtypes based on cellular composition and continuous transcriptional programs not explained by pathology or cognition, providing a more nuanced view of Alzheimer’s biology for patient stratification.

[Nat Rev Neurology @NatRevNeurol]

Proinflammatory Epstein–Barr Virus Antibody Functions Track with Disease Activity in Multiple Sclerosis https://t.co/PfbDxNzYIk

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis: Neuron https://t.co/TwvQGrdSEV

[Ruslan Rust @rust_ruslan]

Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer’s pathology and cognitive resilience: Cell Stem Cell https://t.co/uaWOxeclRd

[Brain @Brain1878]

Corriveau-Lecavalier et al. show that patterns of default mode network dysfunction predict future conversion to amyloid positivity, mild cognitive impairment, and dementia, emphasizing the role of network dyshomeostasis in Alzheimer’s disease. https://t.co/B14bNHaYdf

[Molecular Neurodegeneration @MolNeuro]

Tau extent outperforms tau load as a predictor of #neurodegeneration in #AlzheimersDisease

Arthur C. Macedo, Lydia Trudel, Seyyed Ali Hosseini...Pedro Rosa-Neto @mcgillu

https://t.co/BFVLUynooZ

[Waggoner Lab @LabWaggoner]

Lipid droplets are key immunometabolic platforms in early antiviral defence @NatureComms @ebony_monson @TimetogoZ @Latrobe @JayLaws15
@HelbigLab
https://t.co/ah8nfv4eL9

[Jonathan Kipnis 🟦 @jonykipnis]

https://t.co/QQS4yRjlJ5 On the cover: In this issue of Neuron, Du et al. @DuSiling show that repeated microglial depletion enables peripheral monocytes from both the blood and skull bone marrow to infiltrate the brain and engraft as monocyte-derived macrophages with distinct identities. Inspired by a passage from the Zuo Zhuan (“The first beat of the drum rouses the soldiers’ spirits; the second weakens their resolve; by the third, they are exhausted”), the artwork depicts three rounds of microglial depletion gradually exhausting the endogenous microglial niche. The two advancing armies represent distinct peripheral sources of invading cells: one arriving from the blood, illustrated by the army bearing the red flag, and the other emerging from the skull bone marrow, portrayed as descending from the mountains. Artist credit: Ying Xu.

[Waggoner Lab @LabWaggoner]

Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells @NatImmunol @DonnaFarber3 @Columbia
https://t.co/EetWTCBRxX