Many drugs work by binding to a specific target in the body and blocking or changing what it does. An important first step in the drug development process is designing a molecule that can bind tightly to its target. Traditionally, that's meant weeks or months of expert work per target, sifting through a large number of candidates to identify the few that work.
We wanted to test if Claude could successfully design novel protein binders from scratch (also called de novo design). With a protein design prompt written by a human expert, Claude autonomously designed protein binders against 14 out of 15 targets.
We then worked with Adaptyv Bio and Twist Bioscience, who independently built and tested the proteins Claude designed.
so can we please just ship AGI already, solve all open math problems, and get started with the real work, which is creating large scale simulations of the human body to cure all disease? come on, what is taking us so long
This has been my major issue transitioning from aerospace to biomedical engineering.
In aerospace, EVERYTHING is up for debate. you wana put the wings backwards on a plane? fuck it, Sukhoi su-47. Oh you want intermeshing rotors? Kaman K-max it is.
In medicine, people flex their credentials (“doctor here 👋”) and rely on prior art:
“usually are not”
“standard practice”
“typically not”
EVERYTHING should be grounded in first principles and rigorous testing. Medicine is not like that, because of people like Dr. Kelly Morrison who look at a miraculous full body scanning technology that can see through you at unprecedented resolution- LITERALLY SCI-FI TECHNOLOGY- and can’t imagine using it for preventative means- simply because people haven’t done that before.
You could give a magic X-ray gun to some third world, medieval shaman or witch-doctor and the first thing they would say is “yo we should scan everyone and make sure nothing looks weird inside”.
How is this not the obvious response? I can’t see a future in which everyone isn’t getting MRI’d and having their images analyzed by AI.
The future of medicine IS PREVENTATIVE. i don’t give a fuck what any doctor or pharma company says about it. Their incentive structures have been broken for the last hundred years.
An ounce of prevention > a pound of cure. Please, for the love of God, think a LITTLE outside the box for once!
Ironically, Charlie Kirk would hate this ridiculous statement. He believed in the complete opposite: that free speech means tolerance of all speech, including hateful speech, unless it’s a direct threat or incitement to violence. That’s the whole point of the First Amendment!
As you know, I urge resisting the racial framing as often as possible, and I think it should be done here, unlike what we see from Charlie and Megan, but the psycho did yell "I got that white girl!"
The emphasis shouldn't be on race but failed Democratic criminal policy, etc.
You’ve just ordered Pizza Hut and a 2L Mountain Dew. You’ve loaded up RuneScape on your PC. No school tomorrow. Your parents don’t care if you stay up all night long. A perfect summer night. You are 35 years old. The year is 2025.
DESANTIS ON RIOTERS: "We have a policy that if you're driving on one of those streets, and a mob surrounds your vehicle and threatens you, you have a right to flee...if you hit one of these people, that's THEIR fault. You don't have to sit there."
It's really not whether you "give a fuck about property" per se; it's about whether you want to live in a society that upholds laws that protect people's property, which I very much do. Without that, what do we have?
(Have you *been* to place that fail to do this? Not good.)
Massie plan: Throw the big beautiful bill in the trash. Start over… skinny!
Extend 2017 tax cuts
End Green New Deal cold turkey
No bloat for military industrial complex
No SALT
No pork
Realistic border funding
Serious Medicaid reform
$1 spending cuts for $1 new tax cuts
Whatever.
Keep the EV/solar incentive cuts in the bill, even though no oil & gas subsidies are touched (very unfair!!), but ditch the MOUNTAIN of DISGUSTING PORK in the bill.
In the entire history of civilization, there has never been legislation that both big and beautiful. Everyone knows this!
Either you get a big and ugly bill or a slim and beautiful bill.
Slim and beautiful is the way.
Do you see how scarce #Bitcoin is?
It’s like discovering the scarcest digital land known to man before the rest of the world wraps their head around it.
As a wise man once said, it might makes sense just to get some, in case it catches on.
The flag of technocapitalism.
Inspiring. And completely different from the zero-sum hammer and sickle. Signifies transcendence, escape velocity, exponential growth, and relentless progress.