Great work from PhD students Jelmer Dijksta and @HNeikes in collaboration with @TaurielloLab and Emile Voest: multi-omics and secretomics in tumor progression organoids revealing putative regulators of colon cancer metastasis, including DKK3 and DKK4
https://t.co/wnpLRHcG2F
Our own Beatriz Subtil wrote a blog about the importance of #rest for academics, inspired by the work of @DrDaltonSmith.
Have a look: https://t.co/rrW1C93tVp
"...by prioritizing our rest and well-being, we become more productive, present, creative, motivated, and focused."
As tumours progress, TGFβ drives strong wound-healing programme in CAF & suppress the adaptive & innate immune system, thus facilitating #immunotherapy insensitivity.Overcoming TGFβ-mediated immune evasion in cancer is a difficult but important challenge.
https://t.co/UvQv4cpXNN
With @TaurielloD from @TaurielloLab and @elenasanchosuil we have written this comprenhensive review on the role of TGF-beta over immune cell types in the TME, and the actual landscape of therapies targeting this pathway in #Cancer for @NatureRevCancer
https://t.co/3Rr805NbiV
Together with @BatlleLab, @elenasanchosuil, I wrote a review on Overcoming TGFβ-mediated immune evasion in cancer in @NatureRevCancer. We are very proud of this, and I hope you will enjoy reading it.
https://t.co/c2Ff5WiXKy
If you like #CRC and #immunity, you might want to check out DC (dys)function ... which is exactly what Beatriz Subtil in the lab is doing. And she wrote a beautiful review about it too! With @AlessandraCambi + Jolanda de Vries @TIL_Radboudumc
Out today: https://t.co/oEsR7YChLh
Congrats! to collaborators in the Moscat—Diaz-Meco lab @SBPdiscovery/@WeillCornell, for their publication on TGFB-induced suppression of PKCZ in the CRC #TME—promoting SOX2-mediated #CAF formation; using our @BatlleLab MTOs.
👉Kasashima et al. @Dev_Cell
https://t.co/s1qM20UPgP
Happy to share our latest publication in @embojournal ! We discovered an unexpected class of RNF43 mutations that confer a tumor suppressor-to-oncogene switch. Curious how? Check our video summary 👉 https://t.co/A1Zmmwrk8j @UMCU_CMM @oncodeinstitute 1/4
My lab's first publication is a fact!
Huge kudos to Eline Janssen, Beatriz Subtil & Fàtima de la Jara Ortiz for pulling this off in these weird times, well done!
Also thanks to our super-collaborator Henk Verheul @radboudumc.
May this be the first of many to come! 🥳🎉🥂
As this is the TiMElab's first-TiME publication, this one is very special to us. We learned a lot from researching and writing it, and feel it made something positive out of the Covid-19 lockdown in the process.
Above all, we hope you find it useful!
Interested in #ColorectalCancer research &
#Immunotherapy? Our review offers an overview of the field, plus a perspective towards 'precision I/O': Combinatorial Immunotherapies for Metastatic CRC https://t.co/BW1NSyEnYx via @MDPIOpenAccess @radboudumc_weetn @RIMLSInstitute
And that's a wrap on our #RNAseq course for @CAMBUpenn! Great group of students this year. 21hrs of video lectures are up on our website for anyone who wants self-guided instruction in #rstats and @bioconductor. https://t.co/cvwTtBm1oS
This is a cautionary tale of how anti-Spike antibody may make COVID disease worse. In this study, the authors show that anti-Spike IgG made SARS-CoV disease worse by switching macrophage from wound-healing to proinflammatory phenotype. A thread (1/n)
https://t.co/T8ipHt5tRH
#ibiology recorded three lectures of 20 minutes each covering 30 years or research in my lab. They can be viewed at:
https://t.co/QbysC0TdcU
#stemcells#organoids @coloncancer