Hans Clevers

Professor Molecular Genetics, PI at Hubrecht Institute and Princess Máxima Center, Utrecht NL. Director of Institute of Human Biology of pRED, Roche, Basel CH

[Hans Clevers @HansClevers]

A short write-up about the journey of our lab. Starting as T cell immunologists, we stumbled across Wnt signaling in flies and frogs. Worked on colon cancer. Then Nick Barker (left) discovered the gut stem cell and Toshi Sato invented organoids https://t.co/EzK2hhyONc

[Stem Cell Podcast @stemcellpodcast]

🎙️ We have a new episode out!

We chat with Drs. Shuibing Chen (@ChenShuibing) and Hans Clevers (@HansClevers) from the #ISSCR Consortium on Advanced Stem Cell-Based Models in Drug Discovery and Development

They discuss how stem cell–derived organoids and other new approach methodologies (#NAMs) can complement or replace animal models in preclinical research.

🔊 Listen now: https://t.co/pFpwozH6he

[Scott Isaacs @scottisaacsmd]

Must-read Review in Nature Medicine from @DanielJDrucker: a masterclass on how GLP-1 medicines moved from glucose control to reshaping obesity, CV, liver, kidney, neuro and addiction care.
https://t.co/8ydiYIxdS0

[Hans Clevers @HansClevers]

@IHB_Research @AzadBonni Congrats, Azad!

[Roche @Roche]

The future of faster drug discovery may be on the horizon. #Organoids, tiny simplified versions of human tissues, help us test potential medicines in faster, more predictive ways.

A new review with @Hubrecht Institute explores how.

👏 Thank you to the scientists driving this work.

Read more 👉 https://t.co/DBPM8LMB7Y

#DrugDiscovery #Innovation #pRED @IHB_Research @Hans Clevers

[Hans Clevers @HansClevers]

Daisong Wang and Sangho Lim describe human gut organoids with Peyer's patch M cells. M cells not only transport antigens: like professional antigen-presenting cells, they process and present gluten (the celiac disease antigen) directly to T cells https://t.co/q6Efm59SZi

[Hao Yin @HaoYin20]

Single-chain TS2/16 integrin β1-activating antibody as a soluble supplement

up to 10-fold ⏫ yields of 2D/3D Visceral (small intestine, colon, stomach, pancreas/liver) Organoids🤠

What would be its impacts on blood vessel organoids & assembloids?😆

@HansClevers @TheCleversLab @NatureBiotech 2025
https://t.co/ooYFGgYGWF

[The Abarca Prize @AbarcaPrize]

Explore the gala highlights and see the most memorable moments, featuring remarks by Prof. @HansClevers and jury president Prof. @SilviaPriori1.
⬇️
https://t.co/gtvTobk5sZ

#AbarcaPrize2025 #MedicalResearch #MedicalAward #Organoids

[Joep Beumer @BeumerJoep]

Great opportunity to join a fantastic lab at @IHB_Research !

[Hans Clevers @HansClevers]

Polyisocyanide (PIC) hydrogel with the essential properties of #Matrigel. Functionalised with the integrin activating Yersinia protein #Invasin for #organoid growth. Joost Wijnakker et al. Great collaboration with Paul Kouwer's lab. PMID: 41091766
https://t.co/Ts9R30EQ5T

[Hans Clevers @HansClevers]

Honored to receive the #AbarcaPrize2025. Not surprisingly, I'm very passionate about #organoids and their immense potential to transform how we approach drug discovery and development.  @AbarcaPrize

[Roche @Roche]

Honored to see @HansClevers recognized Abarca Prize in Spain! A remarkable achievement that demonstrates how science and compassion go hand in hand. Find out more about here:https://t.co/QDTpO8Tdfb
#AbarcaPrize #ResearchPrize #EarlyDevelopment #MedicalResearch

[Hans Clevers @HansClevers]

For the #organoid research group that I founded at the Princess Máxima Center, we are looking for a motivated postdoc with experience in gene editing and bioinformatics. Contact Karin Sanders ([email protected]) to learn more. @prinsesmaximac

[Hans Clevers @HansClevers]

https://t.co/lvifbk2TEY

[The Clevers Lab @TheCleversLab]

4/4 This work was a true team effort between @_amolf, @ihb_research, and the @_Hubrecht — led by @DanielKruegerDK and Kasper Spoelstra. Huge thanks to all collaborators for making it possible.

[Hans Clevers @HansClevers]

1/11 In @ScienceMagazine: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. https://t.co/Y2EI9bhhWT

[Hans Clevers @HansClevers]

11/11 Take-home: Gut homeostasis is not passive crowd control. It’s an active, force-regulated process. Cells constantly test each other’s strength; those that fail the tug-of-war extrude. A collaboration between the @_Hubrecht, @_amolf & @IHB_Research lead by @DanielKruegerDK