Professor Molecular Genetics, PI at Hubrecht Institute and Princess Máxima Center, Utrecht NL. Director of Institute of Human Biology of pRED, Roche, Basel CH
A short write-up about the journey of our lab. Starting as T cell immunologists, we stumbled across Wnt signaling in flies and frogs. Worked on colon cancer. Then Nick Barker (left) discovered the gut stem cell and Toshi Sato invented organoids https://t.co/EzK2hhyONc
🎙️ We have a new episode out!
We chat with Drs. Shuibing Chen (@ChenShuibing) and Hans Clevers (@HansClevers) from the #ISSCR Consortium on Advanced Stem Cell-Based Models in Drug Discovery and Development
They discuss how stem cell–derived organoids and other new approach methodologies (#NAMs) can complement or replace animal models in preclinical research.
🔊 Listen now: https://t.co/pFpwozH6he
Must-read Review in Nature Medicine from @DanielJDrucker: a masterclass on how GLP-1 medicines moved from glucose control to reshaping obesity, CV, liver, kidney, neuro and addiction care.
https://t.co/8ydiYIxdS0
The future of faster drug discovery may be on the horizon. #Organoids, tiny simplified versions of human tissues, help us test potential medicines in faster, more predictive ways.
A new review with @Hubrecht Institute explores how.
👏 Thank you to the scientists driving this work.
Read more 👉 https://t.co/DBPM8LMB7Y
#DrugDiscovery #Innovation #pRED @IHB_Research @Hans Clevers
Daisong Wang and Sangho Lim describe human gut organoids with Peyer's patch M cells. M cells not only transport antigens: like professional antigen-presenting cells, they process and present gluten (the celiac disease antigen) directly to T cells https://t.co/q6Efm59SZi
Single-chain TS2/16 integrin β1-activating antibody as a soluble supplement
up to 10-fold ⏫ yields of 2D/3D Visceral (small intestine, colon, stomach, pancreas/liver) Organoids🤠
What would be its impacts on blood vessel organoids & assembloids?😆
@HansClevers@TheCleversLab@NatureBiotech 2025
https://t.co/ooYFGgYGWF
Polyisocyanide (PIC) hydrogel with the essential properties of #Matrigel. Functionalised with the integrin activating Yersinia protein #Invasin for #organoid growth. Joost Wijnakker et al. Great collaboration with Paul Kouwer's lab. PMID: 41091766
https://t.co/Ts9R30EQ5T
Honored to receive the #AbarcaPrize2025. Not surprisingly, I'm very passionate about #organoids and their immense potential to transform how we approach drug discovery and development. @AbarcaPrize
For the #organoid research group that I founded at the Princess Máxima Center, we are looking for a motivated postdoc with experience in gene editing and bioinformatics. Contact Karin Sanders ([email protected]) to learn more. @prinsesmaximac
4/4 This work was a true team effort between @_amolf, @ihb_research, and the @_Hubrecht — led by @DanielKruegerDK and Kasper Spoelstra. Huge thanks to all collaborators for making it possible.
1/11 In @ScienceMagazine: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. https://t.co/Y2EI9bhhWT
11/11 Take-home: Gut homeostasis is not passive crowd control. It’s an active, force-regulated process. Cells constantly test each other’s strength; those that fail the tug-of-war extrude. A collaboration between the @_Hubrecht, @_amolf & @IHB_Research lead by @DanielKruegerDK