Excited to share our new paper: 'LASER couples damage sensing to ESCRT assembly for lysosome repair.' Congrats to dream team @clairegoul and @aakritijain24 for uncovering a new lysosome repair pathway and its connection to neurodegeneration. https://t.co/ZdGtlU0wke
A UC Irvine-led research team showcases how the use of methylarginine targeting chimeras controls the body’s protein degradation pathway. This method signals a new approach to developing drugs that can more effectively treat disease. Read the full story: https://t.co/oOK1MOXpVn
We’re proud to share that Dr. Lauren Albrecht has been promoted to tenured Associate Professor at UC Irvine!
Join us in congratulating Professor Albrecht on this significant milestone and her contributions to our academic community, school, and students! @TheAlbrecht_Lab
RESEARCH | M Campos, LV Albrecht et al. (UC Irvine)
Subcellular compartmentalization of the glycolytic enzyme PFKM regulates cell fate and metabolic switch during skeletal muscle differentiation.
https://t.co/MEw0Vi4Dzw
Honored to have our latest MrTAC research article featured on the Cover of Cell Chem. Here, we develop the first endogenous MrTAC and decode the rules of protein degradability, expanding tissue-specific degrader modalities.
Thanks to @NatureSMB for publishing a "Research Briefing" on our recent work, highlighting the discoveries and providing context on the story behind our research into how vitamin B2 metabolism regulates FSP1 stability to suppress ferroptosis.
1/3 Thrilled to see our paper led by Kirandeep Deol is out! We used CRISPR screens to uncover regulators of the ferroptosis suppressor FSP1. key discovery: vitamin B2 metabolism stabilizes FSP1 via FAD, revealing a new way vitamins regulate ferroptosis.
https://t.co/6WGXNbGRNf
🔬 Researchers with the @TheAlbrecht_Lab at @UCIrvine reveal spatiotemporal dynamics of phosphofructokinase 1, a key glycolytic enzyme, within the skeletal muscle lineage.
@NatMetabolism | https://t.co/yrMoLtOrBL
🔬 Researchers with the @TheAlbrecht_Lab at @UCIrvine reveal spatiotemporal dynamics of phosphofructokinase 1, a key glycolytic enzyme, within the skeletal muscle lineage.
@NatMetabolism | https://t.co/yrMoLtOrBL
A mitochondrial transport protein promotes carnitine synthesis in mice when fat consumption is needed.
Learn more in a new #SciencePerspective: https://t.co/bItBFOXK4s
PROTAC-Mediated Degradation of mHTT Aggregates Attenuates Neurotoxicity in Cellular and R6/2 Mouse Models of Huntington’s Disease | Journal of the American Chemical Society https://t.co/MRNM6PXRz4
What a thrill to see this out! Our prospective, scalable, and target-centric solution for molecular glue discovery.
More thoughts and details here: https://t.co/k1Ylnzd3Cj
Paper here: https://t.co/XtTiavWZcr