The Melton Lab

[The Melton Lab @TheMeltonLab]

#scienceisfun #pride #BlackLivesMattters

[Cell Press @CellPressNews]

Looking forward to keynote talks from @HansClevers, @TheMeltonLab & @GVNlab @CellSymposia #CSStemCells22 #stemcells #LosAngeles #California @CedarsSinaiMed December 8–10, 2022 Register here https://t.co/i8PYkUWe4H

[International Society of Developmental Biology @IntSocDevBiol]

G. Oliver @NU_Lymphatics (🇺🇸@NUFeinbergMed), C. Blanpain @CedricBlanpain (🇧🇪@ULBruxelles) & D. Melton @TheMeltonLab (🇺🇸@harvardstemcell) are the guest speakers in the #ISDB2021 session “𝗙𝗿𝗼𝗺 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁 𝘁𝗼 𝗱𝗶𝘀𝗲𝗮𝘀𝗲”

Join us in 🇵🇹👉 https://t.co/RBAOuYub4E

[Elad Sintov 🎗️ @EladSintov]

Using a CRISPR screen and single cell analyses we asked how do stem cell-derived islets (SC-islets) react to immunological pressure (allogeneic). Among the hits we identified CXCL10 depletion as a way to escape immune rejection of grafted #betacells.
https://t.co/rVm68oh75K

[Cell Press Events @CellPressEvents]

Take a look at the speaker line-up for #CSStemCells22, including keynotes @HansClevers, @TheMeltonLab & @GVNlab #stemcells #LosAngeles #California @CedarsSinaiMed https://t.co/YCADTwjiFq

[Elad Sintov 🎗️ @EladSintov]

Couldn’t ask for a better closure for my postdoc era. Was so great to attend and present at #ISSCR2022! Met so many old and new friends/colleagues. Some of which you see only in meetings like these every few years. Hope to see you all next year in Boston #ISSCR2023 @ISSCR

[Cell Press @CellPressNews]

Cell maturation: Hallmarks, triggers, and manipulation
@TheMeltonLab @Harvard @JuanAlvarezDom @PennCDB @IRM_Upenn @CellCellPress #ISSCR2022 https://t.co/JJIeULQP4k

[Elad Sintov 🎗️ @EladSintov]

Tomorrow 6/16 at #ISSCR2022, excited to present 'Immunogenicity of stem-cell derived islets as defined be a whole-genome CRISPR screen'. In person or virtual.
1:45pm PDT/4:45pm EDT, at 'Stem Cell Bioengineering - enhancing cell function'.

[Dario Gerace @DarioGerace]

Happy to share a pre-print of some work from my time in the @TheMeltonLab. First and foremost, many thanks to all the co-authors involved!! Now, for a brief outline of the findings..

[The Melton Lab @TheMeltonLab]

Check out our latest pre-print entitled “Whole Genome CRISPR Screening of Stem Cell Derived Islets Reveals Gene Targets for Hypo-Immunogenicity”

[Elad Sintov 🎗️ @EladSintov]

Glad and excited to share our online pre-print of a paper submitted for peer review in @CellStemCell. We report a whole genome CRISPR screen and transcriptomic profiling of immune challenged stem cell derived islet cells. See thread below
https://t.co/xBAd9i5O0K

[Dario Gerace @DarioGerace]

I’ve finally settled back home in Sydney, Australia with my family. I’d like to thank Doug and all my colleagues in the @TheMeltonLab for the wonderful years together. Hope to see you soon Down Under!

[StemCellReports @stemcellreports]

This is just one of many good things that might happen when you listen to the Stem Cell Report. Hear more from Doug Melton @TheMeltonLab & @naleite at https://t.co/8T5SyJZd3o & read their recent paper, https://t.co/xxOt5N7Oh2. @harvardstemcell @VertexPharma @ISSCR @martinperaJAX

[ISSCR @ISSCR]

⏰ Don't miss the opportunity to hear groundbreaking research & to network with this impressive line-up of past #ISSCR presidents at the #ISSCR2022 Annual Meeting 15-18 June in San Francisco. Register by 11:59 EDT 13 April for the best rates 👉 https://t.co/U91gxjW1lN

[Elad Sintov 🎗️ @EladSintov]

Probably the last time together with these outstanding people and outstanding mentor. Thank you @TheMeltonLab

[Nayara Leite @naleite]

It was a pleasure to participate with @TheMeltonLab on the @stemcellreports podcast. Thank you for having me!

[ISSCR @ISSCR]

👨‍🔬Hear abt Doug Melton's latest work developing #stemcell therapies for #diabetes @ our Jerusalem symposium. His pioneering work deriving insulin-producing beta islets cells from PSCs led to the 1st in-human clinical trial https://t.co/lkN5Bxbn2Q
@HSCRB @harvardstemcell @Harvard

[ISSCR @ISSCR]

🔬Today in @stemcellreports, research from @naleite, Douglas Melton & colleagues has identified new ways to enhance the SC-beta cell survivability through genetic manipulation of the cells. Read on 👉 https://t.co/SU704vx0KR. Image: The Foundry. @martinperaJAX @TheMeltonLab

[Nature Biotechnology @NatureBiotech]

Diabetes cell therapies take evasive action - @ElieDolgin https://t.co/WL9OdCjxtz

[Mohamed bin Zayed Foundation for Humanity @mbz_foundation]

“The promising results we’ve seen with #stemcell-derived islet cells could deliver a life-changing therapy for people who suffer from the relentless life-long burden of #Type1diabetes," said Dr. Douglas Melton, co-director of @harvardstemcell Institute.

[The Melton Lab @TheMeltonLab]

“Meet the Scientist: Douglas Melton” on https://t.co/uz7VGv6Fxl special thanks to @JDRF and @TheMeltonLab team! @HSCRB

[Juan [email protected] @JuanAlvarezDom]

Are your cells mature? Does it matter? In our latest @CellCellPress, we review Cell maturation: Hallmarks, triggers, and manipulation. We discuss a new framework, based on cell plasticity, to understand how cells become specialized.. @PennCDB @IRM_UPenn
https://t.co/j3owXhlw6b