Pasare Lab

Welcome to the Pasare Lab at CCHMC. Our lab studies TLR signaling pathway and how activation of TLRs influence the shaping of the adaptive immune responses.

[The American Association of Immunologists (AAI) @ImmunologyAAI]

Elevate your knowledge with the Distinguished Lectures at #IMMUNOLOGY2025™. Engage with thought leaders and gain unique perspectives. Register today: https://t.co/lfeFqhlutV.

#WednesdayWisdom

[Pasare Lab @ThePasareLab]

I had once said to Rana " It is not possible to reverse fibrosis" She is well on her way to prove me wrong. Huge implications for diseases where fibrosis results in morbidity and mortality. Congratulations! Rana Herro @herro86957 @CincyChildrens

[The American Association of Immunologists (AAI) @ImmunologyAAI]

#PulmonaryFibrosis (PF) is a condition that leads to the buildup of scar tissue in the lungs. A new study published in @J_Immunol by @herro86957 @CincyResearch identified two novel mediators of PF and demonstrated that targeting both can reverse scarring. https://t.co/IkMfj56KXR

[Cincinnati Children’s Research @CincyResearch]

Check out an article about the study from UW... https://t.co/iMaNc9lNrT

[Pasare Lab @ThePasareLab]

Congratulations! Nandan. Delighted that @nandangokhale will be on the faculty of the Division of Immunobiology @CincyChildrens soon. Can't wait to see how his exciting research unfolds. Welcome! Nandan.

[Nandan Gokhale @nandangokhale]

So excited to join the Division of Immunobiology at Cincinnati Children's Hospital MC in March 2025. My lab will study how RNA biology regulates and is regulated by infection and immunity.

We'll be hiring at all levels in 2025 - stay tuned!

https://t.co/NmOXiIgacE

[Pasare Lab @ThePasareLab]

Join us @CincyChildrens to do exciting research in Immunology. Please apply and forward to colleagues.

https://t.co/irFOTVjffi

[Pasare Lab @ThePasareLab]

Memory T cell derived TNF: Primary activator of innate immune system to drive transplant rejection

[Cincinnati Children’s Research @CincyResearch]

Intriguing new approach to preventing #HeartTransplant rejection shows early promise in mice. Congrats to @ThePasareLab @CincyChildrens @CincyKidsHeart https://t.co/MwaSNKReWa

[Pasare Lab @ThePasareLab]

Activation of the innate immune system by memory T cells (not PAMPs) is the primary driver of transplant rejection @ThePasareLab @CincyChildrens

https://t.co/PllpQBINlX

[Lee Grimes Lab @LeeGrimesLab]

CCHMC Division of Immunobiology is hiring faculty (at all ranks).
Applicants should send a CV, 2-page research plan, and contact information for three
references to [email protected] by March 1st, 2024.

[Pasare Lab @ThePasareLab]

Effector memory CD4 T cells drive DNA damage in Dendritic cells to activate non-canonical STING pathway and subsequent innate inflammation. Stellar work by Hannah Meibers, a graduate student in the lab @CincyChildrens @CincyImmunology @ThePasareLab
https://t.co/yHWbSjXvSZ

[Pasare Lab @ThePasareLab]

Congratulations! Aakanksha. Very proud of you

[Aakanksha Jain @Aakanksha__Jain]

Excited to share that I have received the NIH HEAL K99 award to study the neuroimmune mechanisms of recurring pain. Thanks to my mentors Clifford Woolf @FMKirbyNeuro and @ThePasareLab for guidance and my amazing labmates for reading and re-reading my grant against their will 🤓.

[Pasare Lab @ThePasareLab]

@jkagan1 Thanks very much! Jon. We will be recruiting in several exciting areas of Immunology . @CincyChildrens is an amazing institution to do science and Cincinnati is great place to live @Bengals @Reds @fccincinnati. Spread the word and please contact me @ThePasareLab

[Waggoner Lab @LabWaggoner]

IEC-intrinsic IL-1R enhances IL-22–induced AMPs for protection vs C. rodentium, but contributes to damage-induced inflammation via chemokines & ROS. Congrats Hannah, Garrett, Lisa & @ThePasareLab @kellivd @AlenghatLab @CincyImmunology
https://t.co/k9v5nZWzA6

[Journal of Experimental Medicine @JExpMed]

Overcast, Meibers et al. @ThePasareLab @CincyChildrens characterize the dual role of IL-1R signaling in IECs during C. rodentium infection and DSS-induced #colitis. https://t.co/JGSC3OkWRj

#MucosalImmunology #InnateImmunity #inflammation

[Pasare Lab @ThePasareLab]

Active role for gut epithelial cell IL-1R in fine tuning IL-22 induced anti-microbial response and inflammation through induction of ROS.
https://t.co/nC7cbvtMRU

[Pasare Lab @ThePasareLab]

Division of Immunobiology @CincyChildrens is looking for a new leader. Great place to do exceptional science. Please spread the word and apply
https://t.co/o2n3177glM

[Cincinnati Children's @CincyChildrens]

Potential Approach Emerges to Treat Autoimmunity and Prevent Serious Side Effects of #Cancer Immune Therapies. Congrats to @ThePasareLab @ChildrensCBDI #cytokinestorms https://t.co/3vF8NcoL3s

[Pasare Lab @ThePasareLab]

CD4 T effector memory T cells engage TNFR and CD40 on DCs to cause auto-immune pathology and cytokine storm. New targets for combating T cell induced innate inflammaton. @ThePasareLab @_m_mcdaniel @Aakanksha__Jain @CincyChildrens @CincyImmunology
https://t.co/xzSZO6vOkH

[Cincinnati Children's @CincyChildrens]

Study @NatImmunol reveals how the body's innate #ImmuneSystem senses allergens like #mites, #insects and #fungi. Suggests new targets for treatment. Congrats @RothenbergLab @ThePasareLab ! #inflammation #allergies #foodallergies https://t.co/jXIn1YzIZZ

[Pasare Lab @ThePasareLab]

Allergens activate Ripoptosome to drive Caspase-8 mediated cleavage of IL-33.A step closer to type II sensor? @RothenbergLab @ThePasareLab @CincyChildrens
https://t.co/GDQvN9JW76

[Pasare Lab @ThePasareLab]

@yjgaoustc @DamonRunyon @TheMarkFdn @dgsomucla Very proud of you Yajing. As you can see, this is @thepasarelab's first visit to Twitter in 2021 😀