The Peptide Desk

[The Peptide Desk @ThePeptideDesk]

Everyone's talking about peptides.

Almost nobody knows which one does what.

I made a free cheat sheet: 20 peptides, 6 categories, what each one is for, and how strong the evidence actually is.

🧵 Here's the map — and the download link is at the end.

[The Peptide Desk @ThePeptideDesk]

"People always ask what stack I use.
My go-to stack is:
Retatrutide
Melanotan 2
KPV
GHK-cu
It has truly changed my life".

Before you click on that affiliate link to buy, do yourself a favor and follow this process:
https://t.co/vOpjnfHUDI

[The Peptide Desk @ThePeptideDesk]

@cremieuxrecueil This is great. I wonder about dysesthesia. ~20% of trial participants reported it, but I rarely see anyone mention it on peptidetwit.

[The Peptide Desk @ThePeptideDesk]

@TheCryptoDaddi NAD+

[The Peptide Desk @ThePeptideDesk]

@RobertJCrane @AJA_Cortes That's good news. Taking it AM or PM?

[The Peptide Desk @ThePeptideDesk]

@peptidecaddie @AJA_Cortes In most cases taking a peptide orally is a waste. Small peptides that act systemically with a trigger mechanism are the best oral candidates. Pineal & epital fit that. They don't have much oral data, but lots of positive n=1.

[The Peptide Desk @ThePeptideDesk]

@AJA_Cortes They show benefit on sleep trackers. They're often recommended for evening use, yet they can actually disrupt sleep. Sleeping hot, waking more (but no trouble getting back to sleep). You can try them in the AM if they distrupt your sleep. Lots of positive n=1 experiences.

[The Peptide Desk @ThePeptideDesk]

@hubermanlab It's likely that people will titrate their dosage on gray market peptides as well. Will impact $ flow on what is already a race-to-the-bottom on price.

[The Peptide Desk @ThePeptideDesk]

@_9th_Life_ Maybe with injectables? Maybe not. No matter the source, it will be a race-to-the-bottom on price eventually. That could change if someone is able to take one of the systemic action injectioned peptides and make an oral formulation.

[The Peptide Desk @ThePeptideDesk]

@sanglucci You're right. You could do a lot of work learning to read HPLC & mass spec certs. Then you have to find a seller that will provide them. Many won't which is a red flag. Maybe find a doctor (a real one) that uses peptides in their practice. If they do, it's probably BPC & TB500.

[The Peptide Desk @ThePeptideDesk]

@DailyPeptide Personal experience. 1 or 2 were close to life-changing, others were a waste of $.

[The Peptide Desk @ThePeptideDesk]

@6mg_coolmint @doctormorphh Kind of does the opposite. It's sort of a sunscreen. People who take it before going out in the sun don't burn as easily. I don't think there are any clinical trials on it, but a lot of anecdata.

[The Peptide Desk @ThePeptideDesk]

@doctormorphh I would take a serious look at melanotan II's potential side effects before taking it. It was discovered in the US. They didn't even try to develop it further b/c of side effects. There's a complete discussion of it on my blog if anyone cares.

[The Peptide Desk @ThePeptideDesk]

Take a serious look at the risks of Melanotan II. https://t.co/RFqxDtYPuO

[The Peptide Desk @ThePeptideDesk]

People think that peptides aren't FDA approved because they're from Eastern Europe & have never been studied in the US.

But two peptides were discovered at the University of Arizona. One became a pharmaceutical. The other was never developed because of its dangers, yet it's on the gray market today. Check-out the reply link for the full story.

[The Peptide Desk @ThePeptideDesk]

No data for epitalon, but n=1 sleep reports show an effect. Pinealon has substantial data for oral admin (72 patients w/TBI). Neither has kinetics data. Proteins and peptides don't all get digested down to individual AA's. Some small peptides can enter the bloodstream, but not all. Sellers are in a race to the bottom on price. Like GLP-1's anyone who successfully turns an injectable into an oral will be a big winner.

[The Peptide Desk @ThePeptideDesk]

@drmarlonperalta Figuring-out the time of day to take epitalon and pinealon is interesting. Didn't notice much difference (subjective) for epitalon. Pinealon created 10X more vivid dreams but caused waking. Much better results taking it at 8AM.

[The Peptide Desk @ThePeptideDesk]

@_9th_Life_ Stage 3 can really be stage 1 for most people. Pinealon, Eiptalon, and oral BPC-157. Injection is a big hurdle for ppl to get over, so they have to have a real need before they'll do it.

[The Peptide Desk @ThePeptideDesk]

@rorynotsorry Daily not worth it is probably true, especially for receptor-based peptides where continuous use might cause desenstization. In that case you're just throwing money away.

[The Peptide Desk @ThePeptideDesk]

@AbudBakri Love of the game and knowing the full context & path forward for the project would be plenty. Having controls so that those submitting can't game the results would be important.

[The Peptide Desk @ThePeptideDesk]

@typesfaster It's mixed for sleep. Increases melatonin and can cause deeper, but also interrupted sleep. May depend on whether-or-not you're using it with pinealon. Most peptides are ignored because there's no financial incentive for pharma to fund the trials.