The Real RCT

Medical Student | Sharing evidence-based insights to help you live longer, move better, and think sharper.

[The Real RCT @TheRealRCT]

Most people who lose a lot of weight end up weaker, slower, and “skinny fat.”

But a new wave of medicine is aiming for something different:
Lose fat.
Build muscle.

Here’s why that matters—and how it could change your health forever 🧵👇

[Crémieux @cremieuxrecueil]

Eli Lilly just showed that you can lose tons of fat while barely losing any muscle using their activin type-II receptor inhibitor, bimagrumab.

We are approaching a golden era of weight loss, where everyone can easily be muscular and skinny.

Prepare for hordes of hot Americans.

[The Real RCT @TheRealRCT]

@EricTopol Atherosclerotic cardiovascular disease is completely preventable. I wrote a thread outlining how 🧵👇

[The Real RCT @TheRealRCT]

The leading cause of death worldwide — atherosclerotic cardiovascular and cerebrovascular disease is completely preventable.

We can crush ApoB — the root cause of plaques — and end this disease before it begins. 🧵👇

[Crémieux @cremieuxrecueil]

One of the most cited, esteemed Alzheimer's and Parkinson's researchers, Eliezer Masliah, was found to be a fraud.

He headed the National Institute of Aging neuroscience division, controlled billions in funding, and set the field back by decades.

He should be executed.

[The Real RCT @TheRealRCT]

@cremieuxrecueil Great breakdown. Most of the concerns I hear aren’t about genetics but about side effects. Nausea, constipation, fatigue, etc. are the main barriers, but the data shows they’re usually mild, temporary, and preventable with simple adjustments. 🧵👇

[The Real RCT @TheRealRCT]

Ozempic. Wegovy. Mounjaro.

The weight loss looks effortless.

But the side effects?
Most people only hear horror stories or marketing.

Here’s what the data actually says about which fears are real vs completely overblown. 🧵👇

[The Real RCT @TheRealRCT]

@DrNadolsky Most of these “side effects” make headlines but don’t match the actual data.

I broke down what’s real vs completely overblown here 🧵👇

[The Real RCT @TheRealRCT]

Ozempic. Wegovy. Mounjaro.

The weight loss looks effortless.

But the side effects?
Most people only hear horror stories or marketing.

Here’s what the data actually says about which fears are real vs completely overblown. 🧵👇

[The Real RCT @TheRealRCT]

@Strength4_Life This is exactly it.
Supplements, EMS, and anti-inflammatory strategies can help, but nothing comes close to the protective power of building and maintaining muscle.

[The Real RCT @TheRealRCT]

Diet matters. But you can’t eat your way to strength.

If you want to live longer and move better, there's one intervention that outperforms all others:

Build muscle.
🧵

[The Real RCT @TheRealRCT]

@nearcyan

[The Real RCT @TheRealRCT]

@EricTopol I dug into how GLP-1 drugs were developed and what makes them different.
From the first gut hormone experiments to today’s semaglutide vs tirzepatide showdown 🧵👇

[The Real RCT @TheRealRCT]

Ozempic, Wegovy, Mounjaro.

You’ve heard the names.
But where did they come from?

These drugs didn’t appear overnight.
They were decades in the making—from gut hormones to $100B blockbusters.

Here’s the wild history of GLP-1 meds 🧵

[The Real RCT @TheRealRCT]

@MWeintraubMD Losing too much lean mass on GLP-1s can slow your metabolism, make weight regain more likely, and worsen long-term health.

Here’s how new drugs + training strategies are changing that, so you lose fat while keeping (or building) muscle 🧵👇

[The Real RCT @TheRealRCT]

Most people who lose a lot of weight end up weaker, slower, and “skinny fat.”

But a new wave of medicine is aiming for something different:
Lose fat.
Build muscle.

Here’s why that matters—and how it could change your health forever 🧵👇

[The Real RCT @TheRealRCT]

Saying dreams have "no real meaning" isn't a scientific claim, it's a philosophical presupposition.

Science can explain the how and what of dreams: neural activity, memory processing, threat simulation, etc. But it can't answer why questions about meaning or purpose. That's simply outside its scope.

More importantly, meaning depends on perspective. From the first-person view, or the perspective of a clinician, dreams can be deeply significant. People wake up shaken by nightmares, find insight in symbolic dreams, process grief, trauma, and emotional conflict through dreaming. To dismiss them as "random" or "meaningless" is to ignore the subjective dimension entirely.

Your claim assumes a reductionist materialist worldview, which is itself a philosophical stance, not something science can prove. Using it to deny meaning in dreams is circular reasoning: you're assuming your metaphysics and trying to use it as evidence.

[The Real RCT @TheRealRCT]

@DrNadolsky GLP-1 supplements = scam.
GLP-1 meds = revolution.

They don’t just help you lose weight.
They might protect your brain, fight cancer, and slow aging. 🧵👇

[The Real RCT @TheRealRCT]

Most people think GLP-1 drugs are just for weight loss.

But the truth is far bigger—and far more surprising.

They may protect your brain, reduce cancer, and even change how we age.

Here’s everything you didn’t know about GLP-1s 🧵

[The Real RCT @TheRealRCT]

@davidasinclair GLP-1RAs are hitting inflammation, metabolism, and even brain aging, possibly changing how we think about longevity itself.

Broke it down here 🧵👇

[The Real RCT @TheRealRCT]

Most people think GLP-1 drugs are just for weight loss.

But the truth is far bigger—and far more surprising.

They may protect your brain, reduce cancer, and even change how we age.

Here’s everything you didn’t know about GLP-1s 🧵

[The Real RCT @TheRealRCT]

@404PeterEastman @EricTopol GLP‑1s reduce visceral fat. Sadly, nothing yet for the kind between your ears.

[The Real RCT @TheRealRCT]

@LeddyLLC Resistance training is one of the strongest levers we have – not just for testosterone and sperm health, but for longevity.

Here’s my deep dive on how to train effectively 🧵👇

[The Real RCT @TheRealRCT]

Diet matters. But you can’t eat your way to strength.

If you want to live longer and move better, there's one intervention that outperforms all others:

Build muscle.
🧵

[The Real RCT @TheRealRCT]

If you learned something:

🔁 Retweet the first post to help others
👥 Follow @TheRealRCT for more evidence-based insights on health, medicine, and longevity.

[The Real RCT @TheRealRCT]

Most people who lose a lot of weight end up weaker, slower, and “skinny fat.”

But a new wave of medicine is aiming for something different:
Lose fat.
Build muscle.

Here’s why that matters—and how it could change your health forever 🧵👇

[The Real RCT @TheRealRCT]

Most people who lose a lot of weight end up weaker, slower, and “skinny fat.”

But a new wave of medicine is aiming for something different:
Lose fat.
Build muscle.

Here’s why that matters—and how it could change your health forever 🧵👇

[Crémieux @cremieuxrecueil]

Eli Lilly just showed that you can lose tons of fat while barely losing any muscle using their activin type-II receptor inhibitor, bimagrumab.

We are approaching a golden era of weight loss, where everyone can easily be muscular and skinny.

Prepare for hordes of hot Americans.

[The Real RCT @TheRealRCT]

🔁 TL;DR

• GLP‑1 drugs: lean mass loss at rates of ~25%, similar to other interventions, but up to 40% in some groups
• Bimagrumab & similar drugs: increase lean mass and reduce fat mass
• COURAGE & EMBRAZE: combinations can preserve most of your muscle
• Functional improvements so far are mixed

The next frontier in obesity treatment may be true body recomposition:

Lose fat while preserving—or even gaining muscle mass.