The Schisler Lab

McAllister Heart Institute UNC School of Medicine

[The Schisler Lab @TheSchislerLab]

Such an amazing day at PRISM, the Program for Research, Interviewing, and Scholarship Mentorship. PRISM hosted a graduate student panel coordinated by Kaitlin Blakemore and directed by Dr. Schisler. Current Ph.D., M.D., and M.D./Ph.D. students shared what their interview journeys were really like and gave our PRISM students honest, helpful advice as they prepare for their upcoming application cycles.

We are so grateful for our panelists and for Dr. Schisler’s leadership in building a program that truly supports students and opens doors for them.

[The Schisler Lab @TheSchislerLab]

We are proud of Dr. Jonathan Schisler for presenting at the ACVP
Annual Meeting 2025 in New Orleans, LA!
Dr. Schisler presented "CXCL5: Guardian of Vascular Health in Aging and Space - Protective Roles in Atherosclerosis, Reverse Cholesterol Transport, and Adaptive Space Biology," as part of the Opening Plenary: Insights Into Aging - Explorations of Space Biomedicine, Systems Biology, and Animal Models session.
Congratulations to Dr. Schisler and the team for continuing to advance research on vascular health and space biology! #unc #chapelhill #researcher
🩵👏🧪🐭🐏

[The Schisler Lab @TheSchislerLab]

We are so proud of the amazing work by Becky Sanchez-Hodge, our Lab Manager here at the Schisler Lab and MHI Summer Research Coordinator!
Becky did an incredible job presenting at the Cape Cod Conference, where she shared her research on how exogenous CXCL5 delivery limits plaque formation in a CXCL5-haploinsufficient atherosclerosis model.
She also presented at the Pharmacology Retreat 2025, continuing to showcase the impactful research being done in our lab.
Congratulations to Becky and everyone who played a role in this important work!
#unc #uncresearch #chapelhill #theschislerlab #chapelhill
👏👏🐭🐏🧪🩵

[The Schisler Lab @TheSchislerLab]

We are Proud to Celebrate Dr. Michael Fernandes de Almeida, post doctoral research fellow, who was recently honored with the 2025 Rebecca Clark Staff Award for Moral Courage.
Learn more about his work here:
https://t.co/qoA72wys3R

#UNCmed #theschislerlab #tarheels

[UNC McAllister Heart @UNC_MHI]

Congratulations 👏to Michael F. Almeida in the Schisler Lab @TheSchislerLab. He recently received Rebecca Clark Staff Award for Moral Courage at @UNC's University Day Ceremony. #cardiovascular #research

[The Schisler Lab @TheSchislerLab]

Congratulations to Michael F. Almeida, recipient of the Rebecca Clark Staff Award for Moral Courage at UNC’s University Day! Oct 12th!!
This honor recognizes his courage, integrity, and commitment to doing what’s right — qualities that make a lasting impact on our community. Well deserved, Michael! 🥳#UNC #CarolinaExcellence

[The Schisler Lab @TheSchislerLab]

@AtaxiaUK Congratulations!

[Ataxia UK @AtaxiaUK]

Ataxia UK has recently awarded funding to Dr Stefan Hauser & his research team on spinocerebellar ataxia type-3 (SCA3). Those with SCA3 inherit one mutated version of the SCA3 gene from one parent
& one healthy version of the gene from their other parent. https://t.co/20ufV6Mp6X

[The Schisler Lab @TheSchislerLab]

@drcampatterson the gift that keeps on giving, or degrading, depending on your relationship ♥️🧠

[The Schisler Lab @TheSchislerLab]

🚀 Big News in Neurodegenerative Disease Research and Proteostasis! 🧠✨

We’re thrilled to share our latest paper in the EMBO Journal: “E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A”.

🔬 Key Discoveries:

CHIP-PDE9A Interaction: CHIP binds to PDE9A, promoting its degradation. Dysfunctional CHIP leads to PDE9A buildup and neuron death.
Signaling Pathways: cGMP/cAMP signaling cross-talk is vital for neuron survival. Elevated PKA levels worsen PDE9A buildup.
Therapeutic Potential: Inhibiting PDE9A or boosting CHIP expression restores signaling balance and protects neurons.
📚 Abstract: CHIP mutations increase PDE9A levels, disrupting cGMP hydrolysis and mitophagy, leading to neuron death. Targeting PDE9A-CHIP interaction offers a novel therapeutic strategy for CHIP-related ataxia.

🔗 Read the full paper: https://t.co/tBGiLyJi4D

We’re proud of this achievement and its potential impact on neurodegenerative disease treatment. Special thanks to fantastic team members @nitdawg, @FalmeidaMichael, recent PhD graduate Kaitlan Smith, and our colleagues from Zhengzhou University, including long-term collaborators Changhe Shi and Xuming Xu. Stay tuned for more updates!

#Neuroscience 🧠 #Research 🔬 #CHIP 🧬 #PDE9A 🧪 #NeurodegenerativeDiseases 🧠 #ScientificBreakthrough 🚀 #EMBOJournal 📚

[The Schisler Lab @TheSchislerLab]

🌟 Exciting Opportunity for Undergraduates! 🌟

Are you passionate about cardiovascular research and looking for a meaningful summer experience? Look no further! The McAllister Heart Institute’s Summer Undergraduate Mentoring and Meaningful Experiences in Research (MHI-SUMMER) program is now accepting applications!

🔬 What is MHI-SUMMER? MHI-SUMMER is a comprehensive program designed to inspire and train the next generation of cardiovascular researchers. Our program focuses on providing students with hands-on research experience, mentorship, and career development opportunities.

📅 Program Highlights:
Research Experience: Work in state-of-the-art cardiovascular research labs alongside experienced mentors.
Mentorship: Receive guidance and support from leading researchers in the field.
Career Development: Participate in workshops, networking sessions, and career planning activities.
Diverse Environment: Join a community of students from various backgrounds and contribute to groundbreaking research.

🌍 Why Join? Cardiovascular disease (CVD) remains the leading cause of death in the United States. By joining MHI-SUMMER, you will be part of a program that aims to reduce CVD-related mortality through innovative research and mentorship. This is your chance to make a real impact and pave the way for a successful career in cardiovascular research.

📢 Apply Now! Don’t miss out on this incredible opportunity! Visit our website to learn more about the program and submit your application: https://t.co/MWUarDzB2H

Let’s work together to inspire impactful careers and advance cardiovascular research! 💪❤️

#MHISUMMER
#CardiovascularResearch
#UndergraduateResearch
#Mentorship
#CareerDevelopment

[The Schisler Lab @TheSchislerLab]

🧬 Unraveling the mystery of protein quality control regulation at the molecular level and how it can be hijacked in cancer. Check out our latest article by @mariah_stewart7 and @NitDawg: https://t.co/xEAxCWbrCn 🔬📖.

#ProteinPower 💪 #CellScience 🔬 #BiochemistryBuzz 🧬

[Afshin Beheshti @AfshinBeheshti]

Nice press release from @PittTweet about my new Space Biomedicine Program: "Pitt Launches New Center for Space Biomedicine with Afshin Beheshti at its Helm" https://t.co/3hFsnHObD1 via
@UPMCnews

[The Schisler Lab @TheSchislerLab]

🚀 Exciting article by Alyssa LaFaro! 🌟 Read about @NitDawg’s journey to science, our lab’s research on age-related pharmacology, our commitment to team science, and fueling partnerships to make @UNC a collaborative hub for future space studies. 🌌 Inspired by @zenanaut, @drcampatterson, and 80's love for @NASA, check out how we will pave the way for groundbreaking discoveries in space science with amazing partners, including @AfshinBeheshti, @mason_lab, @RobSchwartzLab, @ncspacegrant, @moreheadplanet, @JMP_software. 🚀✨ #SpaceResearch #AgingScience
https://t.co/23UJxLQJPV

[The Schisler Lab @TheSchislerLab]

🌟 Huge congratulations to @falmeidichael for his outstanding REC Scholar presentation on "Targeting Autophagy to Monitor Age-Related Cognitive Decline and the Dementia Risk"! 🧠✨ Your innovative research is paving the way for new insights into cognitive health and dementia prevention. Keep up the incredible work! 👏👏
Thanks to @NCCU for hosting!
@Duke_UNC_ADRC @UNC_MHI @UNC_PHCO #ResearchExcellence #CognitiveHealth #DementiaResearch

[The Schisler Lab @TheSchislerLab]

🚀 Exciting News! 🚀

Our latest protocol on establishing and maintaining organotypic cerebellar slice cultures (OCerSC) from aged mice is live! 🧠✨ This innovative method maintains the cerebellum’s complex structure ex vivo, enabling detailed studies on neurodevelopmental and neurodegenerative disorders. Check it out for insights into neuronal morphology, functional connectivity, and more!

🔗 Read the entire protocol here: https://t.co/NtJTW9s1Nt

Special thanks to Postdoctoral fellow @FalmeidaMichael and @UNC_PHCO PhD candidate Kaitlan Smith for their incredible contributions! 🙌 Kaitlan and Michael are proud alums of the Bahr lab at @uncpembroke. 🎓

#Neuroscience #Research #Innovation #UNC

[The Schisler Lab @TheSchislerLab]

🧪Excited to announce that @NitDawg will be presenting at the Discovery Summit Americas 2024 in Cary, NC! 🌟 Join us on October 22nd at 2:00 PM to dive into Jonathan’s groundbreaking work on modeling 🧮 antibiotic tolerance 🦠🧫in chronic lung infections 🫁 using @JMP_software featured in a recent publication with @mwolfganglab: https://t.co/BcJWTDXupr

Don’t miss this chance to learn from an expert in multiomics and reverse translational research 💊! #DiscoverySummit #JMP #Research #HealthcareInnovation

🔗 More Info and Registration: https://t.co/zdS31m3IGc

[The Schisler Lab @TheSchislerLab]

Voyager 1, reppin Gen X, still got the moves! 🌌 Showing off its science skills like it's 1977. Who knew the best way to avoid a midlife crisis was to head into interstellar space? #ForeverYoung #Voyager1 #SpaceComeback https://t.co/3MLTqiN24h"

[NASA @NASA]

We’re back, baby!

Our Voyager 1 spacecraft is conducting normal science operations for the first time since November 2023. All four instruments – which study plasma waves, magnetic fields, and particles – are returning usable science data.
https://t.co/3FGBOANXGl

[The Schisler Lab @TheSchislerLab]

Delving into the depths of #Alzheimers research, our REC Scholar @FalmeidaMichael is at the forefront of discovery 🧠. Join us at the IDEAS Forum on June 27 to gain insights into his groundbreaking work 🔍. Register now and be part of the conversation 🗣️. #DementiaResearch @Duke_UNC_ADRC

[REC Core @ Duke-UNC ADRC @REC_dukeuncadrc]

What are our REC Scholars researching in the #Alzheimers space?

Learn more at the next IDEAS Forum, on Thursday, June 27 at 4pm. Register here: https://t.co/0SuzTqfgAw

@aaronreuben @DukePsychNeuro @TheSchislerLab @ECUDPH @Duke_UNC_ADRC @UNCGeriatrics