The way Kenny Rogers’ whole face lights up the moment he hears Dolly Parton’s voice coming from offstage.
I have always loved this performance so much.
She was a delight to direct & so naturally funny. She loved the joke about her make-up remover being strong enough to blow open a jailhouse door. I had her do a few extra unnecessary takes just to make the experience last a little longer. Brightened the day of all in room.
It’s hard to imagine many people having a bigger impact than Dolly Parton. Born in a one-room cabin, she earned 11 Grammys and an Emmy, built a business empire, helped millions of kids learn to read, and — as if that wasn’t enough — helped accelerate the research that led to the Moderna COVID vaccine. What a life. Michelle and I are thinking of Dolly’s family and her many, many fans.
ok shoot big news homies!!
The @Dbacks have asked your boy to come on out and throw the first pitch next week!
Play Ball! ⚾️🧢
See ya at @ChaseField for Dbacks vs Cubs, 8/26!
In 1935, two American doctors examined seven women's ovaries and saw small lumps. They called them cysts and named the disease after them. They were wrong. It took 91 years to fix.
What we called PCOS is now Polyendocrine Metabolic Ovarian Syndrome (PMOS), announced today in The Lancet by an international panel of doctors and patients. The renaming followed more than a decade of consensus work and 22,000 patient and clinician survey responses.
The lumps Stein and Leventhal saw were never cysts. Modern imaging shows they were follicles, the tiny sacs inside the ovary that grow and release an egg each month, frozen partway through by a hormonal imbalance. PMOS is a multi-system disorder centered in the endocrine system, the body's network of glands that produces hormones like insulin (controls blood sugar), cortisol (the stress hormone), and thyroid hormones (set the body's metabolism). The ovary trouble flows downstream from there.
The naming choice is not academic. When doctors hear "ovary" in a diagnosis, they look at the ovary. "Metabolic" and "endocrine" send them to the whole body.
PMOS affects roughly 1 in 8 women worldwide, more than 170 million people. The WHO estimates 70% have never been diagnosed. Among those who do, 1 in 3 wait more than 2 years, and nearly half see 3 or more doctors first. The CDC reports more than half of women with PMOS develop type 2 diabetes by age 40, a risk 5 to 10 times higher than women without the condition. Around 37% have clinically significant depression, compared with 14% in women without it. Anxiety runs at 42% versus 8.5%.
A label born from a 1935 look at seven ovaries is finally going away. The new diagnostic guidelines roll out fully in 2028. By then, a woman walking into a clinic with these symptoms should hear questions about her blood sugar and her mood alongside her cycle. Those are the parts of the disease the old name hid for 91 years.