Tim Springer Lab

Structural Biology. Immunology. Integrins. TGF-beta/BMP. Lab account for PI: @timothyspringer.

[Tim Springer Lab @TimSpringerLab]

📣 The Springer Lab is hiring!

Advance groundbreaking research at the intersection of integrin signaling, organoid development, and cell surface receptor mechanobiology.

https://t.co/y8G4xKeLuI

#postdocjobs, #academictwitter, #ECRchat, #phdchat

[Forbes @Forbes]

Forbes will be co-hosting “America Innovates,” a free, open-to-the-public, family-friendly, three-day experience featuring an immersive walk-through exhibit, as a part of Forbes’ year-long campaign celebrating America’s 250th anniversary.
Meet our speakers: https://t.co/kjVzTqhATP #Forbes250

[Forbes @Forbes]

As the U.S. approaches its semiquincentennial, Forbes is focusing on what has always united the country: the American Dream and the innovation it inspires.

That's why we're launching the Innovator 250, our list of the 250 greatest living American innovators, judged through Forbes’ entrepreneurial lens. #Forbes250 https://t.co/wZUfsJBzc5

📸: Jack Dorsey By Krishna Shenoi For Forbes, Judy Faulkner By Guerin Blask For Forbes, Vlad Tenev By Guerin Blask For Forbes, Oprah Winfrey By Krishna Shenoi For Forbes, Mark Zuckerberg By Guerin Blask For Forbes, Steven Spielberg By Chantal Anderson

[Forbes @Forbes]

Come experience innovations of the past, present and future as Forbes and @America250 cohost America Innovates on May 16-18 in San Francisco.

The event is a free, open-to-the-public expo with business leaders in every industry and Forbes Innovator 250 honorees. https://t.co/Alh9ug13jo #Forbes250 #A250

[Tim Springer Lab @TimSpringerLab]

We’ve joined Bluesky!

Follow the Springer Lab (@springerlab.bsky.social) for insights into integrin and TGF-β signaling, mechanobiology, organoids and regenerative medicine, and structural biology.

#Integrins #StructuralBiology #Biophysics #Organoids #RegenerativeMedicine

[Institute for Protein Innovation @ipiproteins]

A new @nature #cryoEM study on #SARS-CoV-2 details the postfusion spike in a #lipidbilayer, defining the structure of critical membrane-interacting segments that may guide intervention strategies
From researchers @ipiproteins @harvardmed & more ⬇️
https://t.co/GbUIpoAwa2

[Tim Springer Lab @TimSpringerLab]

Thanks @ipiproteins for sharing our work!

[Institute for Protein Innovation @ipiproteins]

From Viet Le & @timothyspringer of @timspringerlab @harvardmed @BostonChildrens:
#Integrin αVβ6 has a specific & unappreciated role in #TGF-β2 activation, unlike the αVβ8-driven activation of TGF-β1/β3 & with big implications for fibrosis drug development
https://t.co/PCLYNCAQxB

[Institute for Protein Innovation @ipiproteins]

@harvardmed @Stanford @UniofOxford @deboramarks @Harvard @UZH_en @osaka_univ_e Hear a panel on synthetic #antibodies & #OpenScience 👇

🧪Errik Anderson, @AlloyTx
🧪@aledmedwards, @thesgconline & @UofT
🧪Andrew Kruse, @harvardmed
🧪Rob Meijers, IPI #Antibody Platform director
🧪Andreas Plückthun, @UZH_en
🧪Meghan Rego, @Addgene

https://t.co/llg7fZjOHR

[Institute for Protein Innovation @ipiproteins]

Don't forget! Join IPI Surfacing tomorrow at @harvardmed. Networking, discussion, posters & talks👇

🧪Christopher Garcia, @Stanford
🧪Yvonne Jones, @UniofOxford
🧪@deboramarks, @Harvard
🧪Andreas Plückthun, @UZH_en
🧪Junichi Takagi, @osaka_univ_e

https://t.co/llg7fZjOHR

[Jon Humphries @JDHL18]

A specialized integrin-binding motif enables proTGF-β2 activation by integrin αVβ6 but not αVβ8 https://t.co/rbwqkaAaM4

[Freddy Frischknecht @FrischknechtLab]

Proteins need to breathe: Stabilising conformations in a #malaria #parasite surface protein stops #Plasmodium #sporozoite migration and blocks transmission. Our latest collaboration with @TimSpringerLab out @emboreports. 'Fixing' TRAP 'kills' the parasite. https://t.co/gI613amWun

[ATUM @ATUM_bio]

Transforming growth factor (TGFß) is key regulator: immune system, development. There are 3 TGFß's; 1,2,3. Springer @BostonChildrens @HarvardMed use @ATUM_bio constructs. Show TGFß2 is activated by separate integrin. New opportunities for treating fibrosis https://t.co/AnYVVEYy76

[Tim Springer Lab @TimSpringerLab]

@ATUM_bio @BostonChildrens @harvardmed pD2529-CAG has become a workhorse in the lab.

[Institute for Protein Innovation @ipiproteins]

🎉 IPI has partnered with @Addgene to provide biomedical researchers worldwide with access to well-validated #antibodies and other reagents, and expertise on how to use them. Look out for our release of a set of #integrin antibodies this fall!

Read more: https://t.co/rurFopgAOW

[Institute for Protein Innovation @ipiproteins]

Recent research by @MyungHyunJO1 @taekjip @XuefengWang11 @timspringerlab & @ipiproteins shows exactly how #integrins harness chemical cues and respond to physical forces.

Curious how it works? Read more here 👇
https://t.co/JxRsizQdk5

[Krzysztof Potempa @BRAINCURES]

Tim Springer is focused on his existing roster of commitments — running a research laboratory of more than a dozen people @TimSpringerLab, overseeing three NIH grants and sitting on six boards, including @SelectaBio, @MorphicTx, @TectonicTx and @Seismic_Tx
https://t.co/l2qndcntHW

[Tim Springer Lab @TimSpringerLab]

@BrianCircleG @LaskerFDN @timothyspringer Hope you are doing well Brian!

[Tim Springer Lab @TimSpringerLab]

Acceptance remarks from @LaskerFDN #LaskerAward winners Richard Hynes, Erkki Ruoslahti, and @timothyspringer for their discoveries concerning #integrins—key mediators of cell-matrix and cell-cell adhesion in physiology and disease:

https://t.co/TBaNK2RzXW

[Institute for Protein Innovation @ipiproteins]

@timothyspringer @LaskerFDN With Richard Hynes & Erkki Ruoslahti, Springer discovered integrins, cell surface proteins that enable cells to interact with their surroundings

Today, IPI is creating antibodies that can bind to integrins to accelerate #basicresearch and #drugdiscovery

https://t.co/POy2fKVGMT

[Lasker Foundation @LaskerFDN]

Congratulations Richard O. Hynes, Erkki Ruoslahti, and Timothy A. Springer, 2022 #LaskerAward winners! — “for discoveries concerning the #integrins—key mediators of cell-matrix and cell-cell adhesion in physiology and disease”.
@MIT @sbpdiscovery @harvardmed
#Lasker2022