Tim Welsh

PhD candidate investigating protein phase separation and other small scale phenomena | @knowleslabcamb @Cambridge_Uni

[KnowlesLab Cambridge @KnowlesLabCamb]

An amazing platform for ultrahigh throughput protein solubility screening! Check the paper:
https://t.co/8eNaL1wBo2

Well done Nadia, Tomas, @OellerMarc, @HAusserwoeger, Aviad, @TimWelsh_ , Rungzhang, @DaoyuanQian219, @VendruscoloLab, Sormanni lab and others!

[KnowlesLab Cambridge @KnowlesLabCamb]

Check out the new DigitISA assay for sensing biomolecular complexes in solution! Well done @GeorgKrainer @KadiLiisSaar @TimWelsh_ @magdaczek @BJacquat and colleagues from Owens, Alberti and Klenerman groups!

https://t.co/ZK52YIcNOj

[Tim Welsh @TimWelsh_]

Our paper on the digital sensing of protein:aptamer interactions is finally published! One platform shows the ability to sense everything from single proteins up to biomolecular condensates and exosomes, while elucidating many biophysical parameters. Congrats to all authors!

[Georg Krainer @GeorgKrainer]

📢 Finally out now: Our paper describing DigitISA, a platform for direct digital sensing of protein biomarkers in solution 🧪 (incl. antibodies, amyloid aggregates & condensates). @KnowlesLabCamb @ChemCambridge Take a look: 👇https://t.co/j6MycHGG5t

[Physical Review X @PhysRevX]

A new method for determining the interaction strengths among compounds that form biomolecular condensates relies on measurements of just one solute in one phase.

Read https://t.co/rflEibNs6I

@DaoyuanQian219 @TimWelsh_ @AbellJonny @GeorgKrainer @MichaelsLabETH @KnowlesLabCamb

[Nature Portfolio @NaturePortfolio]

While antibodies have a remarkable track record in therapeutics, achieving sufficient specificity remains an issue. A Review in @NatRevChem discusses the physicochemistry of non-specificity and outlines future opportunities to improve protein binding. https://t.co/Z2NqrgPpvp

[Tim Welsh @TimWelsh_]

En route to Heidelberg for the #EESPhaseSeparation conference. Only a few more countries to cross before Monday morning!

Come find me all week if you want to chat condensates, microfluidics, or bikes!

[KnowlesLab Cambridge @KnowlesLabCamb]

Check out our preprint discovering DNA-induced LLPS of antibodies based on surface patch driven non-specific interactions: https://t.co/VrHFHnYOun
Great work by @HAusserwoeger, @GeorgKrainer, @TimWelsh_, Tomas, @SchneiderMatth & Therese. Exciting collaboration with @novonordisk

[Tim Welsh @TimWelsh_]

@KnowlesLabCamb #condensates

[Tim Welsh @TimWelsh_]

When theorists and experimentals collaborate good things happen @DaoyuanQian219. Excited to share our work on the measurement and mechanistic insights of tie-lines in biomolecular phase diagrams. Also, maybe we should stop calling PEG an "inert crowder"?

https://t.co/b0aE5iEZxf

[KnowlesLab Cambridge @KnowlesLabCamb]

More from @KnowlesLab at #bps2022 in #SanFrancisco. @eaandrzejewska @mus_greta, Alyssa & @TimWelsh_ presenting posters on pre-fibrilliar protein #aggregates and single-molecules studies, oligomer-membrane interactions, microfluidic spray-deposition & #biomolecular condensates.

[Tim Welsh @TimWelsh_]

Super happy to have contributed to this fantastic piece of work investigating the underlying nucleation mechanisms in solutions of phase separating proteins!

https://t.co/WgX2z8Tzqq

[Tim Welsh @TimWelsh_]

Excited to share our recent work in @NanoLetters investigating the electrostatic forces that stablize protein condensates!

https://t.co/nsBG8xwWwN

Thanks to my amazing co-authors @GeorgKrainer, Jorge, @jerelleaj, @rcollepardo and more for their hard work!

@KnowlesLabCamb

[Tim Welsh @TimWelsh_]

Pretty stoked to finish 4th overall (3rd male) in the British 24hr Cycling Time Trial National Championships

Easily met my main goal of breaking the 55 year old Cambridge University record

Taking a day to recover before training loads of new students on microfluidics this week!

[Mersey Roads 24 @MerseyRoads24]

Updated provisional overall result. Please let us know if any further issues.

[Tim Welsh @TimWelsh_]

@GeorgKrainer You don't want to know 😉 let's just say I'm looking forward to some sleep tonight

[Tim Welsh @TimWelsh_]

CP4 - St Nicholas church #transengland21

[Tim Welsh @TimWelsh_]

Final #transengland21 activity. @theracingcoll

Will be back for more in the future and try to have less mechanicals...
https://t.co/c3ikp1xtHi

[Tim Welsh @TimWelsh_]

Finish 15:54. Brutal #transengland21

[Tim Welsh @TimWelsh_]

CP5 robin hood's bay #transengland21

[Tim Welsh @TimWelsh_]

CP3 highest Inn in Britain #transengland21