An interdisciplinary lab that brings together concepts from chemistry, physics, and medicine to understand protein misfolding and self-assembly. @ChemCambridge
New research from @mvendruscolo14@VendruscoloLab & collaborators compares the phase behavior of four α-Synuclein isoforms & finds stark differences between them in their propensities to undergo phase separation & aggregation; #Parkinsons
https://t.co/dJufc4nFeh
🔥Very excited to see our work just published in Science Advances! https://t.co/9NroW9yB28 "Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments". Grateful for the collaboration with @FBrotzakis, @mvendruscolo14, @VendruscoloLab.
Grateful for the great turnout at my seminar at @ChemCambridge on chaperones and protein aggregation in neurodegeneration 🧠 It was great to connect, discuss research and explore new collaboration opportunities with so many of you! @KnowlesLabCamb@VendruscoloLab@TWIN2PIPSA
A touching tribute by @CVR_Research & Colin Robinson honoring the remarkable life and contributions of Professor Sir Christopher M. Dobson, F.R.S.
A visionary scientist and outstanding mentor:
https://t.co/gFJeWjg3BY
New AI predicts how proteins behave inside cells, starting as small droplets and condensing into larger ones.
This tool predicts how proteins come together using data that are extremely challenging to analyse traditionally.
@PNASNews@VendruscoloLab
https://t.co/DFffsCbgUn
Our latest paper by @Catherine_k_xu
- secondary nucleation is the source of both oligomers and fibrils in Parkinson's associated a-Synuclein aggregation. Fantastic collaboration with Linse lab
@SpillantiniLab and @VendruscoloLab
https://t.co/zlL6BgHoRR
Very excited to share our work in @NatureComms! We show that a-synuclein oligomers and fibrils form by secondary nucleation on existing fibril surfaces https://t.co/LR20fQQX1W
Check out the latest episode (no.9) of the Phase Space Invaders podcast 🎙️ where Prof. Michele Vendruscolo talks about preventing protein misfolding, AI in drug discovery 💊 and the importance of good mentorship 🧠
Access all episodes ➡️ https://t.co/Hw1J51C51w
@VendruscoloLab
The man, the myth, the legend: @StoDada just published a paper with @VendruscoloLab & @ChemCambridge colleagues demonstrating a possible therapeutic route for #Parkinsons based on the inhibition of alpha synuclein protein aggregation within condensates
https://t.co/Ik9N3pc4MT
🎯Excited to share a new article about our #Twin4Promis partner, @mvendruscolo14 and his incredible team @VendruscoloLab from the @ChemCambridge ! 🌟
Learn more about their pioneering work in protein folding here: https://t.co/993SzXtJWS
New research from @robertihorne@KnowlesLabCamb@VendruscoloLab & colleagues presents a machine learning approach to identify small molecule inhibitors of α-synuclein aggregation, a process implicated in #Parkinsons & other synucleinopathies
https://t.co/n17CgiFM3A
Super psyched to see this published at last! We demonstrate a novel approach to slowing alpha-synuclein aggregation in #Parkinsons. A massive thank you to the @VendruscoloLab, @KnowlesLabCamb, Caughey, Ghetti and Sormanni labs.
https://t.co/fHWtkA6eXw
https://t.co/sGUPDzMUPU