Tim @ NumpyNinja

Building Manan, world’s first Medical Grade AI system.

[Tim @ NumpyNinja @Tim_NumpyNinja]

@alexcooldev What about influencers on profit distribution basis?

[Dan Go @CoachDanGo]

How accurate are wearables like Apple Watch, Whoop, and Oura?

A researcher compiled 16 studies to find out, and the answer might shock you:

[Tim @ NumpyNinja @Tim_NumpyNinja]

@Alan_Couzens RHR 50 VO2max 50. That’s elite , not the average person.

[Tim @ NumpyNinja @Tim_NumpyNinja]

@starter_story How did they market it?

[Tim @ NumpyNinja @Tim_NumpyNinja]

@thepatwalls I too had the same one, same color .Bought used for 3000 USD. Clocked 625k miles and donated to a school. Excellent car!

[Tim @ NumpyNinja @Tim_NumpyNinja]

@FilArons UA is not bad once you reach Gold Status. Delta on other hand 😒😒😖

[Tim @ NumpyNinja @Tim_NumpyNinja]

@tidemid 1. Drop the phone
2. Ruthlessly reinforce #1

Get back to us after a week.

[Tim @ NumpyNinja @Tim_NumpyNinja]

@conductr_ Life revolved around a single metric.

Run a startup. Weekly Growth %
Health? Body fat %

Etc.

[Sowmay Jain @sowmay_jain]

i got my whole genome sequenced two years ago and forgot about it.

last week i told my ai agent (@laukiantonson) to dig up my DNA files

• it dug up a two-year-old email
• found the download link
• pulled down 67 gigabytes of raw DNA.
• rented a 32-core, 64GB machine for a few hours — total cost: $5
• aligned 21 million long reads to the human reference genome — 99.83% mapped
• called 5.8 million genetic variants using a two-pass neural network
• phased every variant — separated maternal vs paternal inheritance
• annotated all 5.8M variants against ClinVar, PharmGKB, and gnomAD
• corrected for population-specific bias in the medical literature
• health risk map across 39 conditions flagged in every body system
• drug compatibility guide for 141 medications color-coded by genome response
• nutrient metabolism - 71 variants affecting absorption of vitamins, minerals, iron
• traits, ancestry going back 40,000 years, neanderthal DNA breakdown

$5 in compute. 8 hours. no bioinformatician. no doctor. just one instruction.

we've genuinely reached a point where an ai agent can take your raw genome and hand you back a full personal health profile in a single shot. i had no idea this was even possible.

[Romàn @romanbuildsaas]

I’ve hired over 50 LinkedIn influencers to promote GojiberryAI over the past 3 months.

Average ROI is 1.5x on revenue.

I spend $1 to generate $1.5 in MRR, which is honestly insane.

Here’s what I’ve learned to make it work:

1. Follower count doesn’t matter. Look at likes and comments instead

2. We pay $300 for small influencers, $500 for mid-sized and $750 for large ones. Never above that

3. Check who is liking and commenting on their last 10 posts. If it is always the same people, they might be using a POD

4. Look at their lead magnet posts. If they get between 100 and 300 comments I pay $300. Between 300 and 500 I pay $500. Above that I pay $750

5. I write every post and choose every visual. No guesswork, I know what performs

6. I create a high quality lead magnet that the influencer shares in replies to every comment

7. The influencer’s job is simple. Copy paste my post and reply to comments. That is it

8. Each lead magnet has unique tracking links so I know exactly how much each influencer generates

9. If it is profitable, I double down

10. To find influencers I search by keywords or just scroll. Anytime I see strong engagement in my niche, I reach out

Hope this helps 🙂

[Paul Niklas @PaulNiklas8]

Which ad spy tools are the best at seeing which new ads are quickly gaining impression share?

[Luke Pierce @lukepierceops]

Grant Cardone nails the opportunity here.

Every single company needs AI implementation. The TAM is just too massive to ignore.

I’d push back a bit with leading with a “consulting fee”.

Unless you have extreme authority in that vertical, you’re leaving money on the table. Consulting fees and retainers should be sold on the back end.

Lead with audit and discovery.

Show them what’s broken, what’s possible, and what the ROI looks like.

Then price by impact.

You’ll make way more money. And you’ll actually retain clients because they see results before they see invoices.

Either way, the core message is right. If you’re going to start something right now, start here.

Every company needs an AI team (you) and almost none of them have one yet.

[Tim @ NumpyNinja @Tim_NumpyNinja]

@Bencera You are missing the following

1. Shorter or non existent immigration lines
2. Ability to lie down after a whole day of work followed by another full day of work
3. Faster boarding , faster deplaning
4. Better food
5. Better lounges

[James Lee @jameshyujinlee]

Started using Manus for UGC creator outreach.

We've been getting into Meta Creator Marketplace and I needed to find creators that match our exact ICP.

I asked Manus to find 100 qualified creators who have experience producing UGC content that match our persona.

Guess how much it cost? $3

Manus came back with a full CSV with invitation links + personalized outreach messages for each creator.

The quality of creators they found actually matched our exact customer profile.

[Brian Blum @brian_blum1]

Storytime for people who don't think this is real..

Last year I launched a GLP1 biz as well

We did ~$20m in rev in 6 months

It's surprisingly easy to setup but ruthlessly competitive because there is virtually no differentiation.

Every brand is selling the same stuff.

As a result it is a pure marketing arms race, and Medvi was the best.

They are known for a few things

- Shadowy billing practices
- Highest converting lead funnel
- Running thousands of AI UGC / Theme Pages

When you search Medvi in the Meta Ads library, you'd almost never see something running from their page.

They heavily rely on partnership ads, whitelisting and listicles / advertorials.

On top of leaning heavily into publisher affiliate (Forbes "Best GLP1 Providers") and TikTok's beta for telehealth.

Our funnel was primarily Meta Ads using TikTok Shop style UGC. Worked well til it didn't

The customer is very price conscious and as a result, switches between several brands' intro offers.

So tons of brands spent into CAC's expecting LTV's that didn't materialize. Huge revenue numbers but not a ton of super profitable companies.

Anyways, i've never seen the speed with which we got to $4m/mo in rev. The market was that good.

And behind the scenes everyone knew Medvi, Remedy Meds, Amble were doing $300M+

Everything in the article is true and this guy is a dog

[Corey Ganim @coreyganim]

the AI version of what Kevin is describing:

1. pick a niche (dentists, gyms, med spas, roofers)
2. use Claude to research their competitors, audience, and top-performing content
3. build a content system that creates 30 days of short-form ads in one afternoon
4. run the ads. track customer acquisition weekly. show them the numbers.
5. charge $3-5K/mo per client because you're not selling "content," you're selling customers

Kevin says these people make $250-500K/yr doing this manually.

with AI handling the research, scripting, and repurposing, you can run 5-10 clients at once instead of 2-3.

same skill. 3x the capacity. no team needed.

[Finn Mallery @fin465]

Now that we’re done at YCombinator, we’re revealing how we went from 0 → $10k MRR in our first 30 days, using only ONE channel (step by step).

We spent less than $100 and didn’t have any paid ads, SEO, waitlist, or content marketing.

Instead, we sent 50-75 highly targeted cold emails a day.

Cold email is the most underrated channel because it's hard to get right, but if you figure it out you can sell ANY B2B product.

Here's what we did from start to finish:

STEP 1: Build an ultra‑specific customer profile at both company and person level.

If you do this right, you can mess everything else up and still succeed.

The goal here is to create such a perfect customer, that if they heard about your solution they would have no choice but to say "tell me more".

Step 2: Build your list

After you create this customer profile, find the companies that meet this criteria.

Find 30–50 target companies on LinkedIn, then grab decision‑maker emails via Apollo/Wiza.

STEP 3: Writing a killer email

I used to run an outbound email agency and we'd send 50k+ emails/month to book b2b sales calls via cold email. Here are the basic principles of cold email writing that I always use:

-Keep it 5-8 sentences. 70%+ of emails are read on mobile, so make sure they get most of it from that screen view.
- Never write more than 2 sentences without breaking up the lines. People skim, and that’s the best way to keep their attention
- DO NOT talk about your product’s features.
- Instead, talk about the person, their company, and their pain points.

STEP 4: The call

I took 493 sales calls in Origami’s first 3 months. Here's what I learned:

The 2 biggest goals for this call are
- Figuring out the customer’s problems
- Getting the customer excited about your solution

Unless you already have PMF, it doesn't matter if you have a full built product. You still need to spend 90%+ of your time figuring out what the customer actually needs.

In the early stages, you can even offer a full refund if they aren’t satisfied to give them maximum confidence and get your first few deals over the line.

STEP 5: Closing/After

Congrats! You cracked cold email.

This was the exact approach we used at Origami to get our first $10k MRR, and the highest converting outbound approach I’ve seen when I ran my agency.

I posted the stats in my prior tweets, but in our first 40 days we sent 3119 emails (~77 per day) and got a 5.3% response rate, resulting in demos with 64 founders at companies within our ICP.

This resulted in ~$22k new MRR by the time our sales for all of these calls had closed.

The best part is that once you nail this process, you can automate it. We've got our Origami AI Agents (@origamichat) finding new customers 24/7, which frees us up to explore new channels and focus on scaling.

CONCLUSION

This is a very short version of my guide. The full guide I posted on X last year (@fin465) hit 800k impressions and 10k+ bookmarks.

If you want me to DM it you, comment GUIDE.

[Tim @ NumpyNinja @Tim_NumpyNinja]

@SinaHartung UES hands down .

You get MET , Central Park zoo and the reservoir. Plenty of outdoor stuff.

[69kov @levikov]

1.3 billion women globally are about to hit menopause and they're awake at 3am with hot flashes googling "why can't I sleep anymore" willing to spend literally anything on relief…

The average menopausal woman spends $2,000-$4,000 per year on symptom management. That's supplements, cooling products, hormonal support, sleep aids, skincare for hormonal changes, bone health, mood support, brain fog remedies

It's a $600B+ emerging market growing 17% year over year. And maybe 5 people on the entire internet are running faceless AI pages for it

Every 24-year-old marketer is selling pre-workout to gym bros fighting over the same exhausted customer base. An entire generation of women with disposable income and burning daily problems is being completely ignored because young men don't understand hot flashes and don't think about menopause for a single second

And that blind spot is probably the widest gap between "audience size" and "people serving them" in all of ecommerce right now

These women are 45-60 years old. They're on Facebook and Instagram for hours every day. They're in groups with names like "Menopause Support Sisterhood" and "Women Over 50 Wellness" with hundreds of thousands of active members

They're dealing with:
- Hot flashes that wake them up 3-4 times per night
- Brain fog so bad they forget words mid-sentence
- Weight gain concentrated in the midsection that won't respond to diet
- Joint pain that appeared from nowhere
- Mood swings that are destroying their relationships
- Bone density loss that terrifies them
- Skin changes that make them feel invisible

Every single one of those maps directly to a high-commission supplement category on Amazon. Hot flashes --> cooling supplements and black cohosh. Brain fog --> lion's mane and omega-3. Joint pain --> collagen and turmeric. Bone density --> calcium and vitamin D3. Mood --> ashwagandha and magnesium

And the emotional state of these women makes them incredible buyers. They've been dismissed by doctors who told them "it's just hormones." They've been ignored by a wellness industry that markets exclusively to 25-year-olds. They feel invisible and frustrated and desperate for someone who actually understands what they're going through

An AI character for this niche: a warm grandmother. A female wellness elder. A holistic health guide for women in transition

She posts daily: "The one mineral most women over 50 are deficient in that's causing your joint pain." "Why your doctor didn't tell you about this natural alternative for hot flashes." "3 things I wish I'd known before menopause hit me at 47"

This audience doesn't just watch. They CLING to this character. They comment paragraphs about their own symptoms. They tag their friends. They share videos in private group chats with the caption "this is exactly what I've been going through"

The bond forms faster in this niche than anywhere else because these women feel unseen by everyone and suddenly someone is speaking directly to their experience every single day

Product videos for this audience barely require a pitch. "I struggled with hot flashes for 2 years before I found this." Drop the supplement. The audience is pre-sold because 15 educational videos already proved the character understands their body better than their own doctor does

Automated DMs: "Comment RELIEF and I'll send you my daily menopause routine." Three real tips. Fourth is the product. Open rates on these messages are at the top of anything I've seen in any niche because the emotional urgency is through the roof

And the REPEAT purchase rate is absurd. Menopause lasts 7-14 years on average. A customer who finds products that help doesn't stop buying for a DECADE. One conversion can generate $2,000-$4,000 in lifetime affiliate revenue from a single person

1.3 billion women. $600B market. 17% annual growth. An audience that is actively begging for someone to help them. And almost no one is doing it

we're doing a free live training today where we break down this entire system from scratch.

product selection, character creation, scripting, video generation, all of it.

run by 12 operators who've done $70M+ in GMV… people who've attended are hitting $10-30k/mo within their first few months.

no face, no experience, no following needed.

comment "APEX" and i'll dm you the link. it's free (or look in bio)

[Alfred Lin @Alfred_Lin]

A CEO from one of our portfolio companies shared this with their team. I’m re-sharing it with their permission, because it resonated and reflects what all founders and CEOs should be communicating.

--
We are living through a period of compounding change. And in moments like this, the biggest risk is no longer making the wrong decision. It is moving too slowly while the world moves around you.

There are two paths. We can play defense:
- Protect what we have
- Optimize what works
- Wait for clarity

It feels safe. It isn’t.

Or we can play offense:
- Learn faster than the environment changes
- Use new tools to solve old problems in better ways
- And create entirely new strategies and businesses

That’s where the opportunity is.

Challenge yourself to do things faster and better than you have ever attempted. Stay uncomfortable. Stay on the front foot.