Tim Liu

Full-stack clinician and engineer | improving front-end patient care through back-end biomedicine, data science, and tech

[Tim Liu @TimingLiu]

🧵 Could polygenic risk score (PRS) be used to explore diabetes misclassification? We examined this in a British South Asian cohort @EastLondonGenes with genotyped data and linked health record, now available on @medrxivpreprint https://t.co/A6s2ePQPCr 1/12

[Tim Liu @TimingLiu]

Explore the map: https://t.co/iR1Q0Kezqg

When you were choosing where to work, did the hospital’s IT systems influence your decision?

[Tim Liu @TimingLiu]

When I was choosing my training programme, one thing mattered to me: would I be working with electronic patient records and electronic prescribing?

These are the tools you use every day. I wanted to know what I’d be working with before choosing where to go.

[Tim Liu @TimingLiu]

The data is a work in progress. Some entries come from trust-level sources rather than individual hospital confirmation, so the evidence and its limitations matter.

[Tim Liu @TimingLiu]

If you organise a rota and want help trying this with your team, comment below or message me. What’s the biggest obstacle to letting doctors choose their shifts?

[Tim Liu @TimingLiu]

Why can't doctors decide when they can work?

We're building self-rostering to be free, for all, forever.

Pick shifts. Build a draft. See the gaps.

Early access:
https://t.co/SuRruJqQw6

[Tim Liu @TimingLiu]

@blaisethom Can you turn the flash to be permanetly on?

[Tim Liu @TimingLiu]

@mchlhess The LinkedIn auto-replies are genius

[Tim Liu @TimingLiu]

Built a few key features into sync over the weekend with the help from GPT sol 5.6

- Integrated chat function for organising socials
- Shift swapper to get the annual leave you want
- Payslip verification with rota to track income

Try it out at https://t.co/nCZ431DxMG

[Tim Liu @TimingLiu]

Over a year ago, a call with @ravi_sola changed my life.

Since then, I’ve watched how @PrimaMente grow with speed, creativity, rigour, and relentless drive, pushing deep tech into clinical applications. It’s been inspiring to witness, and even better to be part of.

[Prima Mente @PrimaMente]

1/ Today we announce Pleiades, a series of epigenetic foundation models (90M→7B params) trained on 1.9T tokens of human methylation & genomic data. Pleiades accurately models epigenetics for genomic track prediction, generation & neurodegenerative disease detection from cfDNA, outperforming previous pure DNA baselines.

[Prima Mente @PrimaMente]

Over the coming weeks, we will be introducing Prima Mente to the world. We kicked off today at @NVIDIAGTC Paris highlighting two foundational collaborations:

@nebiusai has become a core partner for our work to generate the world’s largest brain foundation models. Our goal long-term: understand the brain across health, age, and disease.

Through @nvidia DGX Cloud with Lepton, we have started to scale our exciting work in Alzheimer’s Disease to Parkinson’s.

Thank you to Arkady Volozh and Jensen Huang for supporting what will be the biggest application of AI in our world today - human health.

It is a privilege to work with both the @nvidia (Janisha Anand, @cedricSteenb, Ben Griffiths) and @nebiusai (@romanchernin, Danila Shtan, Ilya Burkov, Hasan Göktuğ Çolak, Anastasia Ustinova) teams.

Links to both press releases are in the thread.

[Yan Shao @yan__shao]

🚨 We’re #hiring a Staff Scientist to drive innovative computational workflows for large-scale, multi-omics data in human microbiome research @LawleyLab @sangerinstitute

📅 Closing date: 27th April 2025

📢 Please share & apply!

https://t.co/RFTeEqru47

[Ahmed Alaa @_ahmedmalaa]

How should we evaluate #LLMs for downstream clinical use cases? In this @npjDigitalMed article, we propose a transition from static QA-style benchmarks to dynamic agent-based simulators, similar to methods used in biology, epidemiology & social sciences.

https://t.co/giyVwMZDpl

[Hilary Martin @hilsomartin]

Congratulations to my student @tenghiangh on her first PhD preprint! It's about recessive associations in @GenesHealth , a cohort of >40k British South Asians. See her thread for an account and the paper here https://t.co/tRadSYboVV.

[Kaitlin Samocha @ksamocha]

Our paper describing a way to infer the phase of rare variant pairs using gnomAD v2 is out now in Nature Genetics.

We hope that the resource we generated will be useful when interpreting rare co-occurring variants in the context of recessive disease.

https://t.co/29Qflr6Yce

[Pearse Keane @pearsekeane]

So brilliant that @DrXiaoLiu @sktywagner could showcase for @RishiSunak our work on #oculomics #FoundationModels #RETFound and #Equity #Safety of AI-enabled Healthcare

Proud UK can be a leader in Artificial Medical Intelligence 🇬🇧🇬🇧

@Moorfields @UCLeye @uhbtrust @unibirmingham

[MedTech Foundation @MedTechFndation]

MTF is excited to announce we will be delivering a talk as part of Ipswich Hospital's Basic and Laproscopic Surgical Skills Course. The event is free to attend and will be in person at Ipswich Hospital on October 13th.

Hope to see you there!

[Nicky Whiffin @nickywhiffin]

Is anyone here using the UKBiobank 200k genomes dataset? We are having some weird issues and are trying to troubleshoot if data vs code 😬 Anyone else seeing anything odd?

Either way, please share! 🧬

[Siegfried Wagner @sktywagner]

Great lineup for the inaugural webinar from the Consortium for Vision and Oculomics in Psychiatry @CVOPorg