Together Trial

A Multi-Center, Adaptive Platform Randomized Controlled Trial to evaluate the efficacy of repurposed therapies in treating early SARS-CoV-2: the TOGETHER trial

[Together Trial @TogetherTrial]

TOGETHER Study finds ivermectin no more beneficial than placebo in reducing hospitalisations or ER observations >6 hours in 12 sites, double-blind, platform RCT in Brazil https://t.co/WADMrW4sj3

[Gilmar Reis MD, PhD @dr_gilmarreis]

In 20 Jan 2021 @TogetherTrial enrolled its first patient. Exactly one year later nobody could predict these waves and variants of concern that are still overcrowding public health worldwide. Still so much to learn!
#COVID19 #Omicron #research @NIH @PublicHealth @GloboNews

[Together Trial @TogetherTrial]

Inexpensive anti-depressant could be best COVID treatment yet, Canadian-led trial finds https://t.co/C7eA9Byc2L

[Together Trial @TogetherTrial]

Correction: The switch to three doses of Ivermectin in the TOGETHER Trial occurred before the most recent interim analysis. The trial schema has been updated on the website.

[Together Trial @TogetherTrial]

Our first evaluation of HCQ and LPV/r is also published now in JAMA Open Network. You can access it here. https://t.co/YCryXSUvdi

[Together Trial @TogetherTrial]

The updated TOGETHER Trial schema is now posted to our website. https://t.co/kIIi8C3ItY

[Together Trial @TogetherTrial]

A well-researched article summarizing the findings of trials, including @TogetherTrial, evaluating the effectiveness of repurposed therapies for outpatient treatment fo COVID-19 by @elandhuis

[Esther Wei-Yun Landhuis @elandhuis]

Outpatient #COVID19 drugs could already be on pharmacy shelves, but testing them takes time and $$ that gov't & pharma will rarely spend. Thanks to philanthropy (eg @treatearly @Parsemus), studies are in progress & should yield answers soon. 1/n
https://t.co/2YJgpxITnz

[Together Trial @TogetherTrial]

@socialHATchat @Covid19Critical We have amended our protocol paused allocation to the ivermectin arm while the IRB reviews our amendment to include 3 doses.

[Together Trial @TogetherTrial]

“Results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide more specific, evidence-based guidance on the role of ivermectin in the treatment of COVID-19.” - NIH recommendation Feb 11th 2021

Alright. https://t.co/kIIi8CljSy

[Together Trial @TogetherTrial]

@maggieoutabout Hi there, thanks for connecting with us. The study protocol amended since the change in study arms from HCQ and LPV/r will be posted this week. We'll tweet it out as well.

[Together Trial @TogetherTrial]

@maggieoutabout At this time we only have regulatory approval for recruitment from Brazilian and South African regulators. Seeking approval from Health Canada would take longer than the trial - we will have results from Brazil and SA in 4-6 weeks.

[Together Trial @TogetherTrial]

The previous iteration of the TOGETHER Trial evaluating HCQ and LPV/r was stopped by our DSMB for futility - (publication soon). The story of HCQ was one of unnecessary politicisation. Here is a narrative commentary by our team on the Rise and Fall of HCQ. https://t.co/5MbCFXur3e

[Together Trial @TogetherTrial]

"The need for treatments in early disease is paramount. Evidence is quickly emerging that suggests a number of drugs may have a promising effect on reducing COVID-19 disease severity in patients with mild to moderate disease”

- Dr. Edward Mills, principal investigator

[Together Trial @TogetherTrial]

Our website is now live and our first tweet is out. Check us out at https://t.co/kIIi8C3ItY and follow us for upcoming information on the TOGETHER Trial #covidtrials #covid19