Tom Sephton

Postdoc at RWTH Aachen (@leonorilab) doing organic chemistry and stuff, PhD at Uni of Manchester (@greaneygroup /Butterworth group).

[Leonori Lab @LeonoriLab]

Excited to share our latest work on chemical permutation, now published in @Nature! Using photochemical conditions, we've developed a method to selectively and predictably transform the structures of thiazoles, isothiazoles, and other azole systems.

[David Whalley @DavidWorley94]

Proud to share my first paper as corresponding author from my postdoc at @ASTRAZENECAUK. We found a way to make oxa-BCH rings from simple allyl alcohols in a fast cascade reaction, with control of substitution at every position. @ChemicalScience https://t.co/76hrpV94LT

[Giacomo Crisenza @GEMCrisenza]

📢An up-to-2 years PDRA👩‍🔬👨‍🔬position is available in our research group, as part of an EPSRC-funded research programme (ALKe-Syn). If you fancy functionalizing hydrocarbons using electricity🔌light💡or both – please apply here: https://t.co/la5u8MlQJN
Deadline 31Oct2024
Please RT!

[Tom Sephton @Tom__Sephton]

Great to see this out in it's final form!

[Angewandte Chemie @angew_chem]

XAT-Catalysis for Intramolecular Biaryl Synthesis (S. Butterworth, M. F. Greaney and co-workers) @greaneygroup @Tom Sephton https://t.co/eM6uiDmhKt

[Greaney Group @greaneygroup]

We’re really excited to disclose the final version of our protocol to synthesise benzenes from pyridines in a single operation via an N to C switch, now online (and open access) @Chem_CP. Congrats to Aife for her solo efforts on this project!
https://t.co/jw3MlxvVta

[Tom Sephton @Tom__Sephton]

@DavidWorley94 @greaneygroup @angew_chem Cheers David!

[Tom Sephton @Tom__Sephton]

I had a lot of fun with this project, really cool to see it in print. Check it out over a coffee!

[Greaney Group @greaneygroup]

Just accepted in @angew_chem, we report an amide linked, photocatalytic STR biaryl synthesis that can be telescoped to achieve a challenging C-N arylation of anilines. Check out @Tom__Sephton's work here!
https://t.co/FuQMkyRNCa

[Greaney Group @greaneygroup]

Just accepted in @angew_chem, we report an amide linked, photocatalytic STR biaryl synthesis that can be telescoped to achieve a challenging C-N arylation of anilines. Check out @Tom__Sephton's work here!
https://t.co/FuQMkyRNCa

[Greaney Group @greaneygroup]

Out now in Chemrxiv, we're excited to report a simple protocol for the direct synthesis of benzenes from pyridines, through an N to C switch. Congrats to Aife for her work on this project! https://t.co/Sg7fgTY4CD

[Procter Group @GroupProcter]

Check out our latest publication in @ACSCatalysis: Flavin-photocatalysis 💡and a general platform for the C-H functionalization of sulfides. Cyanation, alkenylation and alkynylation - including reaction of biorelevant sulfides and peptides. Well done Alex and Ollie! 🔗⬇️

[Greaney Group @greaneygroup]

Just accepted in @angew_chem, we report a tunable system for C4/C5 Pyridine C-H arylation using Zincke imine intermediates. Congrats to Haiwen for all his work on this solo effort!
https://t.co/bOvqODrxfq

[Tom Sephton @Tom__Sephton]

It's cool to see that people are interested in our work!

[J Org Chem/Org Lett @JOC_OL]

Here they are! Our most read, recently published #OrgLett articles so you can see what everyone is finding interesting. Please have a look:

https://t.co/NPs70zwtWN
https://t.co/T8DjSrlLsK
https://t.co/qhhsTQpMvT
https://t.co/jR4GSeLcpn
https://t.co/YxMqY0QL3C

[Angewandte Chemie @angew_chem]

Aryne-Enabled C-N Arylation of Anilines (Michael F. Greaney and co-workers) @greaneygroup @Tom_Sephton @itudakos @Trujillo_Group #openaccess https://t.co/NNddLGBEg7

[Tom Sephton @Tom__Sephton]

@DavidWorley94 @greaneygroup Cheers dude!

[Tom Sephton @Tom__Sephton]

Had a great time working on this with Tasos for the past couple of years almost, really cool to see it finally out!

[Greaney Group @greaneygroup]

Fresh out in @angew_chem, we use arynes to accomplish a C-N arylation of electron-poor anilines, unlocking the aniline C-N bond as a functional handle for arylation. We're really happy to see this out!

https://t.co/IGY1pCyDDl

[Tom Sephton @Tom__Sephton]

Really excited to share this! It's a reaction that I've had a lot of fun with and was a great project to work on. Check it out over a coffee!

[Greaney Group @greaneygroup]

Just out in #orglett (@JOC_OL) we report a new and exciting approach to pyrrolidinone synthesis using a Smiles-Truce cascade!

Check out @Tom__Sephton's work, in collaboration with the Butterworth group and sponsored by @lifearc1.

https://t.co/LouKlHv1yG

[Greaney Group @greaneygroup]

... and today, Tom gave a talk about an interesting synthesis of functionalised pyrrolidinones!

[Account not in use @CeciliaRFS]

Hot off the press! A review by infectious disease experts addressing the value and implementation of rapid diagnostic tests in antimicrobial stewardship across low-to-middle and high income countries (open access) https://t.co/6WFA08KhMx

[Greaney Group @greaneygroup]

Check out our first paper of 2022! We explore the use of sulfinamides as aryl transfer agents, and synthesise some cool sterically-hindered diarylamines, in collab with the Butterworth group and @lifearc1, out now in @JOC_OL

[Greaney Group @greaneygroup]

How can we use a ring-opening process to drive an arylation reaction? Without transition metals?

Check out @DavidWorley94’s strain-release Truce-Smiles rearrangement, just accepted in @angew_chem