Total Syntheses

Total Syntheses of Natural Products

[Total Syntheses @Total_Syntheses]

@MarkLautens @geordifrere His Chem206 will keep educating more and more generations of young chemists.

[Total Syntheses @Total_Syntheses]

@KRHornberger Nice story. It reminded me my experience with dichloroketene generation. It requires distillations of POCl3 and CCl3COCl before use, but the [2+2] worked only for the first time, not in the second or third repeats. Fortunately, I found a paper using sonication and it worked well.

[Total Syntheses @Total_Syntheses]

@sarah_reisman Maybe TfCl through azetidinium

[Dirk H. Trauner @DirkTrauner]

One of the greatest joys in science is Anticipation. Check our our review on Natural Product Anticipation written with @BelindaHetzler and Andy Lawrence @biomimetic_chem.

@Total_Syntheses @nyuchemistry @EdinburghChem @NatRevChem

https://t.co/8zP0eLk0rP

[National Academy of Sciences @theNASciences]

#NASmember David W.C. MacMillan of @Princeton receives the Nobel Prize in #Chemistry for “the development of asymmetric organocatalysis,” a precise new tool for molecular construction. MacMillan shares the prize with Benjamin List.

[David R. Liu @davidrliu]

Here are the #Omicron #SARSCoV2 mutations in each gene and the drugs, candidates, & vaccines that target them. The 3CL protease and RNA polymerase have only 1 mutation each (unlike spike, which has >30); the drug candidates targeting them might be more likely to retain efficacy.

[The Nobel Prize @NobelPrize]

BREAKING NEWS:
The 2021 #NobelPrize in Chemistry has been awarded to Benjamin List and David W.C. MacMillan “for the development of asymmetric organocatalysis.”

[Total Syntheses @Total_Syntheses]

@J_A_C_S @karen_wooley Agree. Longer Communications can be split back to back like before. It is important to publish preliminary interesting findings from the labs with limited resources to make large tables.

[Total Syntheses @Total_Syntheses]

@Chemjobber NMR matches natural isolates

[Dirk H. Trauner @DirkTrauner]

Happy 85th birthday, Sam, chemist and Mensch!

[Total Syntheses @Total_Syntheses]

@geordifrere @Chemjobber @Dereklowe @RealTimeChem Neat triethylborane and trimethylaluminum.

[Total Syntheses @Total_Syntheses]

@DMart_82 @DrLCsquare L-Selectride