Nathan Treff

[Reprogenetics Institute @Reprogenetics_]

Kudos to @nucleusgenomics for sponsoring this IRB study testing whether screening embryos based on polygenic risk scores will decrease implantation rates compared to screening only on embryo morphology!
https://t.co/KVSkL0GRlF

[Nathan Treff @TreffDNA]

@nucleusgenomics For anyone interested in learning more about PRISM, participating in the study, or discussing opportunities for collaboration, please reach out at [email protected].

Study registration: https://t.co/zzfYScBUnb (NCT07841769)

[Nathan Treff @TreffDNA]

Many IVF programs treat the ASRM Opinion as a guideline for polygenic embryo selection. I’m pleased to announce the launch of PRISM (Polygenic Risk-Informed Selection versus Morphology), one of the largest clinical studies of polygenic embryo analysis to date. More in thread.

[Nathan Treff @TreffDNA]

@nucleusgenomics I welcome discussion with others working in reproductive medicine, genetics, and embryology, including those with different perspectives on the clinical application of polygenic risk information.

[Nathan Treff @TreffDNA]

@nucleusgenomics For anyone interested in learning more about PRISM, participating in the study, or discussing opportunities for collaboration, please reach out at [email protected].

Study registration: https://t.co/zzfYScBmxD (NCT07841769)

[Nathan Treff @TreffDNA]

@nucleusgenomics PRISM is a non-inferiority clinical trial evaluating whether incorporating polygenic risk estimates into embryo selection affects implantation rates vs. conventional morphology-based selection. Published clinical outcome data on this remain limited.

[Nathan Treff @TreffDNA]

@nucleusgenomics I welcome discussion with others working in reproductive medicine, genetics, and embryology, including those with different perspectives on the clinical application of polygenic risk information.

[Nathan Treff @TreffDNA]

Thank you @ENBrown for the insightful piece.

Like when I talked with the Times, we are now one step closer to giving more people a path to parenthood, and that definitely is something to celebrate.

[reason @reason]

Gene-editing human embryos may now be a reality.
https://t.co/ITVD5CJqyu