TRiMster3

Fascinated by transformative power of new therapies for intractable maladies.Not investment advice.

[Reverend Jordan Wells @WellsJorda89710]

🚨To every Black person tempted by the antisemitic wave sweeping right now:🚨

Back when white mobs lynched us in the streets...
When we had no money, no power, and literally no movement...

Who stood with us? Who risked everything?

The Jews.

They weren't just allies—they were family in the fight.
- Jewish leaders co-founded the NAACP in 1909 and funded/led it for generations when no one else would.
- When Dr. King and our people were arrested, beaten, jailed—Jewish lawyers defended us for free, and Jewish money paid bail bonds and court fees while others turned away.
- In Freedom Summer '64, half the white volunteers risking death to register Black voters? Jewish.
- Rabbi Heschel marched arm-in-arm with MLK in Selma—our struggles linked forever.

Without their blood, treasure, solidarity, and courage—there is no Civil Rights Movement as we know it. No Voting Rights Act. No dream realized.

That's why I stand with the Jews.
They were our only true friends when this country hated us—when doors slammed shut and ropes hung high. They showed up, bled, and built with us.

So to my people joining this demonic, divisive hate today:

Pause. Remember. Honor the alliance that freed us.

Our histories are bound. Our freedoms were won together.

Betray that, and you betray the very martyrs who died for our rights.

Black-Jewish unity forged the dream. Don't let hate destroy it.

I stand with my Jewish brothers and sisters—always. ✊🏾🤝✡️🇮🇱

Repost if truth > trends. If gratitude > division. If history matters.

#BlackJewishAlliance #RememberOurAllies #StandTogether #CivilRightsTruth #NoToAntisemitism

[Tom Rowan 🇺🇸🇮🇱🇮🇷🎗🥂 @TomRowan777]

@EFischberger @josh_hammer

[Henshi @HenshiG]

Dr. Orli Peter, a clinical and neuropsychologist writes a letter to Ms. Rama Duwaji….

Dear Ms. Rama Duwaji,

You publicly liked social media posts describing the Oct. 7, 2023 attack on Israel by Hamas as “collective liberation.” You also placed a heart next to an Instagram post claiming that the reports of mass rapes on Oct. 7 were a “hoax.”

For the past two and a half years, I have been treating survivors of October 7, helping them slowly rebuild shattered lives and broken nervous systems. Some were suicidal. Others could barely speak. Some of the people sitting across from me in therapy had witnessed rapes and executions so brutal that their nervous systems simply shut down. Words stopped working.

These people did not simply survive war. They survived mass and socially sanctioned sadism.

Subsequent investigations by journalists, forensic teams and international bodies documented widespread sexual violence that day.

Families were burned alive.

Festival goers hunted down, raped and then executed.

Hamas terrorists documented much of the violence themselves: one attacker used a victim’s phone to call his parents and brag that he had killed 10 Jews with his own hands; and you surely saw the footage of Shani Louk, whose body Hamas fighters paraded through Gaza in the back of a truck while crowds spat and celebrated.

Survivors of the Nova festival have also described militants laughing as they hunted festivalgoers hiding in the fields.

These were not acts carried out in secrecy. They were recorded, boasted about and, in some cases, carried out with visible pleasure.

These were not only acts of murder. They were staged performances of cruelty. This was not violence used as a means to an end. It was violence relished for its own sake. That is the socially sanctioned mass sadism my patients are still haunted by, superimposed on everything they see.

Once that sadism becomes undeniable, the narrative has a problem. Mass murder can still be reframed as resistance. Rape cannot. It exposes the cruelty too clearly, so it has to be denied.

That denial carries consequences not only for the survivors I treat but for Palestinians as well. Refusing to confront the mass sadism of Oct. 7 keeps Palestinians trapped under the same violent movement that terrorizes them.

Hamas has long brutalized its own population. Human Rights Watch and Amnesty International have documented torture, arbitrary detention, and killings of Palestinians accused of dissent or collaboration, and journalists have reported Hamas beating and arresting Gazans who protest its rule. This is what authoritarian movements do. Cruelty outward. Repression inward.

As New York City’s first lady, you are in a public position to inspire a movement for Palestinian rights and safety.

The survivors I treat are still trying to rebuild their lives after what they witnessed. Palestinians deserve to be free from the same sadistic movement that terrorizes them as well.

Public gestures matter. When someone in a position of influence treats atrocity as liberation, the signal travels far beyond a social media post.

The evidence is clear. Admit that you were wrong and withdraw your support for the lie.

Some of us spend our days helping survivors rebuild the lives that Hamas shattered.

The least the rest of the world can do is stop sanitizing mass sadism and tell the truth about what was done to the victims of Hamas’ cruelty.

Dr. Orli Peter is a clinical and neuropsychologist and founder of the Israel Healing Initiative, established after the Oct. 7 attacks dedicated to advancing trauma recovery and healing based on neuroscience. She can be reached at [email protected].

[Orli Peter @orlipeter]

The posts the First Lady of New York “liked” were supporting Hamas —a designated Foreign Terrorist Organization by the U.S. State Department —which makes it obviously the public’s business.

But beyond her public support for a terrorist group being in the public interest, it raises a deeper question: what does it say about the soul of a mayor who chooses someone like that as his partner?

The terrorists she publicly “likes” carried out the largest murder of Jews since the Holocaust, including more than 30 Americans - an attack carried out with sadistic glee: babies, Holocaust survivors, and elderly civilians kidnapped and dragged into tunnels, families burned alive in their homes, civilians raped and tortured.

I couldn’t even have lunch with someone like that. Could you?

https://t.co/Q8xwbmDYUq

[Dennis Michael Lynch @TrustDML]

As a person who ran from the first tower collapse after watching my fellow Americans jump to their death, and as a guy who has spent every year since 9/11 trying to warn of Islam and mass immigration—both illegal and legal—there is never a day that passes when I don’t pray to God and ask if I’m doing what I’m supposed to be doing. I ask for signs. Then I touch my steel cross from the tower wreckage and feel the 3,000 angels who trust me to Never Forget. This includes fireman George Cain who I never met—I only know his mother. And she asked me to never stop doing what I do. She handed me that steel cross. It was hers, but she gave it to me and said, “Keep this knowing that 3,000 angels will be by your side.” So George is like my brother from another mother. And it pains me greatly to know that for decades I’ve tried to warn of Islam only to watch our country fold like a wet napkin. This morning I asked for a sign a little harder than usual because of the attempted NYC bombing, and the prayer rugs that now sit under the NYFD memorial. I feel like my effort/work is falling way too short; I thought that after 25 years maybe it’s time to move onto something new. Then, tonight, at 10:35p, instead of going to bed I decided to watch videos on X. It is something I rarely do at night. The first video that popped up was Trump on Letterman in 1986. Then the next was Katie Miller interviewing Elon Musk. Both were sorta useless videos. And then this video came up: It was the sign. I listen to these voice messages and it hurts to think how we let 9/11 happen, it hurts even more to know we are handing our cities and countries over to these animals. It all gets me fired up. So I ain’t changing a damn thing. In fact, I’m hitting the gas pedal even harder. I sure hope the signs keep coming. Either way, those of us who TRULY Never Forget—we will prevail or die trying. I’ll be trying again tomorrow George, I promise.

[TRiMster3 @Trimster3]

$IBRX @DrPatrick

[Dr. Pat Soon-Shiong @DrPatrick]

Here is the exciting world of AI. My presentation of the cancer mind map after a decade of work to prove the hypothesis that empowering the innate and adaptive immune system could cure cancer.

So I dictated some of my talk to an AI platform and became the "source" that is mentioned in this audio... amazingly, it took my mind map and created this conversation! Take a listen, it explains beautifully how we think about attacking cancer.

[Casey Babb @DrCaseyBabb]

I can't comment on every single act of antizionism and anti-Jewish hatred, but I must say, what Spike Lee did during the @NBA All-Star Game was one of the more deplorable things I've seen in a long time.

Sadly, though, it was very on-brand for the Palestinian movement. Indeed, Spike didn't wear a Palestinian outfit to celebrate a Palestinian player. Rather, he wore it with the soul-purpose of signalling to the only Jewish player that he isn't welcome. This is the very ethos of Palestinianism. It's not about love, celebration, and a shared future. Instead, it revolves around hatred, demonization, and returning to a past now long gone.

But in my mind, this isn't about Palestinians. It's about a young Jewish man who has spent his entire life mastering his craft, only to have the symbols of his slaughterers visible in the front row of his first All-Star Game. It's absolutely disgusting and I really hope that one day, these despicable acts of bigotry come to an end — it’s got to stop.

[Adi @Adi13]

“My mother survived hell… and still taught me to love life.” -
Gene Simmons ✡️

By Gene Simmons

My mother’s name was Florence Klein.
She was a young Jewish girl in Hungary when the world decided that we were not human.

She had dreams.
She had family.
She had a simple life.

And within months… everything disappeared.

The Nazis sent her to a concentration camp.
They took away her name.
They turned her into a number.
They stole almost everyone she loved.

She saw the worst of humanity.
Hunger that bends the body.
Cold that pierces the bones.
The constant fear of not waking up the next day.

But there was something they could never take from her.

Her identity.

She survived the Nazi extermination camps not because she was the strongest physically…
but because she refused to let her spirit die.

When the war ended, she was alone in the world.

Alone.

And do you know what she did?

She didn’t choose self-pity.
She chose to rebuild.

She immigrated to Israel.
She learned Hebrew.
She worked hard.
She became a nurse.
She saved lives… after having come so close to losing her own.

Then she made an even braver decision:
To bring life into the world.

I was born in Haifa.
I grew up knowing my mother had walked out alive from a place where millions could not.

She didn’t talk much about the horror.
But her silence screamed history.

She taught me discipline.
She taught me pride.
She taught me that being Jewish is not just a religion.
It is memory.
It is resilience.
It is victory.

Years later, when I became Gene Simmons of KISS, when I stood on stages before thousands of people, with fire, lights, and roaring guitars…

I wasn’t just a rock star.

I was the son of a Holocaust survivor.

Every applause was an answer to the attempt to erase us.
Every sold-out arena was a message to the past:

“You failed.”

My mother never sought fame.
Never sought recognition.
But her very existence was an act of historical defiance.

The Nazis tried to turn the Jews into dust.

She became a root. 🌿

She built a family.
She raised a son who would conquer international stages.
She lived long enough to see Israel strong.
To see her son succeed.
To see that the Jewish people did not disappear.

That is victory.

Not the victory of power.
But the victory of survival with dignity.

My mother taught me that hatred does not build empires.
Perseverance does.

That fear paralyzes.
But identity liberates.

And that when the world tries to define you as a victim…
you can choose to be invincible.

She survived hell.
And from her ashes… I was born. 🔥
Am Israel Chai.

[TRiMster3 @Trimster3]

RIP victims of Dec 14 ‘25 terror attack Reuven Morrison, Rabbi Yaakov Levitan, Dan Elkayam, Alex Kleytman, Rabbi Eli Schlanger, Edith Brutman, Peter Meagher, Tibor Weitzen, Marika Pogany, Matilda Tania Tretiak, Boris Tetleroyd, Adam Smyth, Sofia and Boris Gurman #AmYisraelChai 🕎

[TRiMster3 @Trimster3]

$ARWR $ALNY #RNAi #GeneSilencing @BioBoyScout @ArrowheadPharma

[BioBoyScout @BioBoyScout]

@yaireinhorn @Carolynyjohnson @WSJ @kiranmusunuru @davidrliu @bradloncar @BiotechCH @daphnezohar @TimOpler @john_evans3 1/2 RNAi was built for this moment: programmable gene silencing on a scalable platform.
#RNAi has a strong and growing safety track record, because it doesn’t permanently alter DNA. It selectively turns down harmful proteins driving disease. $ARWR $ALNY

[TRiMster3 @Trimster3]

$IBRX @DrPatrick @ImmunityBio

[Dr. Pat Soon-Shiong @DrPatrick]

I have received so many enquiries as to how did the Saudi FDA work with us to grant approval of Anktiva for lung cancer and bladder cancer. We submitted over 1.6 million pages of data ! The SFDA thoroughly reviewed these and on the basis of the clinical results made the decision to provide accelerated approval for Anktiva in lung cancer  ..the FIRST IN THE WORLD!!

Explaining how the SFDA went about their review and their approval is best described in their own words below: 

“ Positive Results Demonstrated in Clinical Studies
The approval of Anktiva is based on a comprehensive evaluation of all available evidence—including efficacy, safety, and quality—in accordance with regulatory requirements. For NSCLC, results from a single-arm clinical trial in patients who had previously not responded to one or more therapies, including immune checkpoint inhibitors, demonstrated a potential improvement in survival. Based on these findings, the SFDA granted conditional approval for this indication. A confirmatory trial to demonstrate long-term clinical benefit is required to maintain this approval status.
For NMIBC, clinical trial results sowed a complete response rate of 62%. The approval for this indication was based on the complete response rate as the primary endpoint. Collectively, these results led the SFDA to consider Anktiva as a new treatment option for patients with limited therapeutic alternatives, contributing to improved disease and survival outcomes.

Sustained Efforts to Achieve National Objectives
This approval reflects the SFDA’s continued commitment to innovation and expanding access to advanced treatment options, thereby enhancing the quality of healthcare in alignment with the goals of the Health Sector Transformation Program, one of the key initiatives of Saudi Vision 2030.”

[TRiMster3 @Trimster3]

“Will provide updates next week on our Bladder cancer papillary disease discussions w FDA & updates on the exciting studies of growing NK cells & storing billions of these cells….”
“The evolution of the Bioshield platform is unstoppable even though external forces try!” $IBRX

[Dr. Pat Soon-Shiong @DrPatrick]

Thanks for sharing your research into our decades of work and the tireless team working hard to find a cure for cancer and to treat chronic and infectious disease ! Good summary of key clinical trials ongoing @immunitybio of the Bioshield program including our now completely enrolled trial to PREVENT cancer for over a million Americans at risk with Lynch Syndrome and a 80 percent higher risk of colon cancer because of a genetic abnormality.

Will provide updates next week on our Bladder cancer papillary disease discussions with FDA and updates on the exciting studies of growing NK cells and storing billions of these cells for treating patients with cancer with off the shelf NK cells that have been activated ( called Memory -Cytokine Enhanced Natural Killer cells or m-CENK for short) and manufacturing them at scale with Anktiva as the growth factor, creating a product and no longer a process …by launching the world’s first AI driven cell manufacturing robots that we have taught with machine vision algorithms to replicate our complex process of growing these m-ceNK cells by the billions and freezing them in storage 24/7 in a clean room “robot machine”. The cost reduction of cell therapy and CART cell therapy as a result has the real potential to change the field and make this next generation cell therapy combined with Anktiva …what we call immnunotherapy2.0 …accessible and affordable to those who need it.

The evolution of the Bioshield platform is unstoppable even though external forces try!

A good read below.

[TRiMster3 @Trimster3]

$IBRX @DrPatrick @ImmunityBio

[Dr. Pat Soon-Shiong @DrPatrick]

Seeing is believing. The patient with multiple bone tumors after failing standard of care and complete response after just 4 doses of our targeted NK cells. And now in ongoing remission 7 months with no further treatment. The power of NK cells is self evident.

Outpatient treatment without lymphodepletion and toxic chemo. A paradigm change

https://t.co/pBuLJz3Mer

[TRiMster3 @Trimster3]

🇮🇷Pray for the very brave people of #Iran. 🇮🇷 #StandWithIranians 🇮🇷

[TRiMster3 @Trimster3]

$ARWR #Redemplo @ArrowheadPharma @_ShahKruti

[Kruti Shah @_ShahKruti]

The big takeaway?

Patience is the ultimate alpha. ⏳

Biotech isn't just about the discovery; it's about the architectural mastery of delivery.

Arrowhead has built the "iOS for DNA." 📲🧬

10/11

[TRiMster3 @Trimster3]

$ARWR @ArrowheadPharma #Happy2026 🎉 @Denada670519 🎶

[Denada @Denada670519]

As 2025 comes to a close, I wanted to share a different kind of year-end reflection.

Over the year, I’ve tried to share the analytical side of Arrowhead’s story on Substack, carefully and in hindsight, using public sources.

In parallel, this music was written inside the year, track by track, as an ARWR investor living through it alongside many of you.

One is aimed at analysis. The other at expressing what the experience was like.

Wishing everyone a healthy, thoughtful, and productive 2026. $ARWR

https://t.co/Xk4yoRPtV6

[TRiMster3 @Trimster3]

$ARWR #FCS #Redemplo @ArrowheadPharma @RobertLKruse

[Robert Kruse, MD, PhD @RobertLKruse]

I’ve had the pleasure to work with Arrowhead to get expanded access to Plozasiran. It’s been life changing for my patient, like a miracle drug. Maybe the most humbling experience I’ve had in medicine to see a drug quickly cure a previously intractable disease. Congratulations!

[TRiMster3 @Trimster3]

$ARWR #Redemplo #FCS @ArrowheadPharma

[ArrowheadPharma @ArrowheadPharma]

🚨 FDA APPROVED! Arrowhead’s therapy to lower triglycerides in adults with Familial Chylomicronemia Syndrome (FCS) offers new hope for patients & families facing this #RareDisease. A major step forward in RNAi innovation. #FCS #FDAApproval

https://t.co/MtQrGqqkvZ

[Reverend Jordan Wells @WellsJorda89710]

I once wondered how a society could stand by as 6 million Jews were murdered in gas chambers, how people became so desensitized to human life. Now I see the vile rhetoric blaming Jews for every societal ill—a twisted, irrational hatred that defies logic. It’s not just human; it’s a dark, anti-Christ force at work. I’ll keep calling out this demonic antisemitism. Never again. #StopHate #NeverAgain

[Jews Fight Back 🇺🇸🇮🇱 @JewsFightBack]

🚨 Jews make up just 0.2% of humanity.
And half of us live in a country smaller than Maricopa County, Arizona.

So when mobs scream to “wipe it off the map” or “from the river to the sea” that’s not politics. That’s a call for extinction.

Remember that.
H/t @ScottJenningsKY