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Barkley Marathons - The Course Wins
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Its always a fun time rapping on Trail Talk.
The Media Pass iteration of the panel discution brought a unique viewpoint to the table on some great trail running topics.
@CindyScott17868@ajoneswilkins Did you miss 2022 when Killian broke 20hours at UTMB a CR, won Zigama, was 4th Sierra Zenal, and won and set a new CR at Hardrock all in the same pair of shoes.
Not trying to say David is not on a heater but there is no way he wins Zigama ever-full stop!
A few important points on the autocrine role of lactate in human performance and muscle bioenergetics.
1.Lactate is a major (if not the major) fuel for muscles (Brooks, 2022 https://t.co/QzbsHJq3q5)
2. When glycolysis is accelerated, cytosolic NAD+ levels decrease. Cellular redox status and NAD+/NADH ratio can be disrupted. Lactate is the key player during glycolysis to replenish NAD+ through the reduction of pyruvate to lactate for the continuation of glycolysis and maintenance of Redox status.
3.Lactate inhibits/decreases CPT-1/2 activity and therefore affecting mitochondrial fatty acid transport and oxidation as well as decreasing maximal ATP production and mitochondrial respiration (San Millan et al, 2022 https://t.co/tc7dNMgHwf)
4. Lactate inhibits phosphofructokinase (PFK) which is a rate-limiting enzyme in glycolysis. Therefore, very high levels of muscle lactate will eventually decrease glycolysis by inhibiting PFK (Leite et al, 2011 https://t.co/2wNbecEZu3)
5.Hydrogen ions associated to lactate (also ATP hydrolysis) elicit a characteristic “muscle microenvironment” with through decrease pH. Increased H+ and decrease pH can interfere with Ca2+ release from SR, troponin C sensitivity and cross-bridge cycling, all resulting in decreased of both strength and velocity of muscle contraction (Metzger and Moss, 1990 https://t.co/CYv0O2r8Ja).
@ajoneswilkins@hardrock100 This does not surprise me as someone who has finished both GS courses and Hellbender.
Hellbender is hands down a harder course.
What I think makes GS sneaky hard is the 6pm start.
@aidstationfireb I could make a huge feed order for you or you could have it delivered to my house and pick it up at Grindstone. It would only cost you a few precision gels;)