AMCS Working Group

The acute mechanical circulatory support (AMCS) working group @TuftsMedicalCtr focuses on clinical and translational research related to the use of AMCS devices

[AMCS Working Group @Tufts_AcuteMCS]

Kevin Morine completed a T32 post-doc, General Cardiology, and Interventional Cardiology Fellowships at Tufts. 14 publications and counting. This report in @CircAHA identified a novel functional role for BMP9 in cardiac remodeling. A true Interventional Cardio-biologist!

[Allen A. Razavi, MD @AllenRazavi]

Thank you to the @IACardiology for allowing me to present on behalf of the @Tufts_AcuteMCS. I had a great time!

[William Suh, MD @willsuh76]

Conventional wisdom:⏱is ❤️. Not in this 🐷 study. 30 min of unloading prior to revasc ⬇️infarct size. Science behind #S2S #DTU #Impella

[Stephan Achenbach @Steph_Achenbach]

Place microaxial pump in all STEMI? We may in the future, says JACC swine study (https://t.co/w2DTCu8Fg9): Impella 30min before opening artery decreases scar size. No benefit 15 min before or after reperfusion, though. Brilliant editorial! (https://t.co/fRrz4hthsa) #cardiotwitter

[Paola Morejón Barragán @paomorejon]

Mechanical Unloading in #HeartFailure
-Post-AMI
•1-year: 25% will develop #HF
•5-years:75% will develop #HF
-Impact of LV unloading with #MCS on reverse remodeling
•Early: ⬇️infarct size
•Late: Myocardial recovery

#CardioEd #FoamEd
@JACCJournals

https://t.co/Rv20fKakkp

[AMCS Working Group @Tufts_AcuteMCS]

DTU vs DTB. Great session at @cvinnovations today discussing the concept of acute cardiac unloading and recovery @acurepublic in acute myocardial infarction. More work to be done @Tufts_AcuteMCS @TCTMD @crfheart @AHAMeetings @SCAI

[JACC Journals @JACCJournals]

Does door balloon time or door to LV unloading matter more in patients w/ #HeartFailure due to acute MI? https://t.co/hyRLuNKQBn #JACC

[AMCS Working Group @Tufts_AcuteMCS]

Congratulations to our @Tufts_AcuteMCS fellows for their recent first author publications. For house officers or fellows interested in translational research, applications for the 2019 AMCS research position are open @CircAHA @CircHF @CircRes @JACCJournals @SCAI @acurepublic

[AMCS Working Group @Tufts_AcuteMCS]

Kevin Morine completed a T32 post-doc, General Cardiology, and Interventional Cardiology Fellowships at Tufts. 14 publications and counting. This report in @CircAHA identified a novel functional role for BMP9 in cardiac remodeling. A true Interventional Cardio-biologist!

[AMCS Working Group @Tufts_AcuteMCS]

Michele Esposito, Yali Zhang, Xiaoying Qiao, and Lara Reyelt collaborated to execute this upcoming report in @JACCJournals exploring the biologic mechanisms underlying the Door to Unload concept in AMI. Daily Mantra for our crew : Work Hard, Play Hard, Make a Difference.

[AMCS Working Group @Tufts_AcuteMCS]

@JWMoses @willsuh76 @fischman_david @DrAmirKaki @SVRaoMD @mirvatalasnag @jaygirimd @DavidLBrownMD @cardiojaydoc02 @rwyeh @DocSavageTJU @Radial_ICG @duanepinto @LambertHeart @DrSaririan @CardiacConsult @purviparwani @bcostelloMD @DrMarthaGulati @DrToniyaSingh @DavidMayMD @ajaykirtane @GreggWStone @brianrshawdo @NirmanBhatia @HeartOTXHeartMD How do we design a shock trial without accounting for post-cath management? Who manages your AMI Shock acute MCS patient after we scrub out? A critical care algorithm is needed. Intensivists improve outcomes in shock with less aggressive care (see attached), but how and why?

[AMCS Working Group @Tufts_AcuteMCS]

@JWMoses @willsuh76 @fischman_david @DrAmirKaki @SVRaoMD @mirvatalasnag @jaygirimd @DavidLBrownMD @cardiojaydoc02 @rwyeh @DocSavageTJU @Radial_ICG @duanepinto @LambertHeart @DrSaririan @CardiacConsult @purviparwani @bcostelloMD @DrMarthaGulati @DrToniyaSingh @DavidMayMD @ajaykirtane @GreggWStone @brianrshawdo @NirmanBhatia @HeartOTXHeartMD NCSI tests an algorithm focused on intra-procedural decision making (early support & hemodynamics) to address prior failed assumptions: no hemo data, all shock is the same, support timing is unimportant. Can't design an RCT without more info. Here is the algorithm if u missed it

[AMCS Working Group @Tufts_AcuteMCS]

Amazing PT Team @TuftsMedicalCtr Study from @Tufts_AcuteMCS Mobility Level with Impella 5 associated with clinical outcomes. The Lazarus Registry now being built with @Abraham_Jacob @shelleyhallmd @JHMontfort10 Join the axillary and ambulatory MCS movement with 5.0 @acurepublic

[AMCS Working Group @Tufts_AcuteMCS]

Axillary 5.0: Optimal approach to descend from the peak of Mount Renal Failure (note creatinine curve) in advanced heart failure failing medical therapy. @acurepublic @TuftsMedicalCtr #Hemodynamics #Unloading

[AMCS Working Group @Tufts_AcuteMCS]

@Abraham_Jacob @shwinner @ajaysmd @yaleHFdoc @StavrosDrakos @EiranGorodeski @ishlt @JHMontfort10 @DukeHFDoc @shelleyhallmd @SunitChaudhryMD Axillary 5.0: Optimal approach to descend from the peak of Mount Renal Failure (note creatinine curve) in advanced heart failure failing medical therapy. @acurepublic @TuftsMedicalCtr

[AMCS Working Group @Tufts_AcuteMCS]

@Abraham_Jacob Using hemodynamic support devices without hemodynamic guidance is like flying blind. If you’re looking for evidence please see every shock trial involving acute MCS. Pumps pump, but people save lives, especially if they have hemodynamic data in hand.
@Tufts_AcuteMCS @acurepublic

[AMCS Working Group @Tufts_AcuteMCS]

TCT Hemodynamic Support Equation and Acute MCS Platforms. Goals of Acute MCS treatment in shock. Acute MCS to solve the equation. @TCTConference @CircAHA @ACCinTouch @acurepublic #ECMO #Impella #Shock #MCS #Hemodynamics #Unloading #Ecpella

[AMCS Working Group @Tufts_AcuteMCS]

RVADs among LVAD Recipients. RV failure post LVAD implantation remains a problem. Don't hang your hat on one number or parameter. Global markers of illness severity are needed. @CircAHA; @TuftsMedicalCtr @ACCinTouch #Impella #ECMO #TandemLife #Shock #RVAD #LVAD #MCS @acurepublic

[AMCS Working Group @Tufts_AcuteMCS]

IABPs in Advanced Heart Failure. Rare data exploring PV loops in advanced HF. Counterpulsation without native LV pulsation leads to non-responder status. @CircAHA; @TuftsMedicalCtr; @ACCinTouch #Impella #ECMO #TandemLife #Shock

[AMCS Working Group @Tufts_AcuteMCS]

Shock Profiles in F1000 Reports. Hemodynamic guidance to define shock profiles and select optimal support strategies. How does one manage shock without a pulmonary artery catheter? @CircAHA; @TuftsMedicalCtr; @ACCinTouch #Impella #ECMO #TandemLife #Shock

[AMCS Working Group @Tufts_AcuteMCS]

Bipella Multicenter Series. First published series of biventricular Impellas for Cardiogenic Shock. Hemodynamic efficacy. Lessons: Simultaneous not Staged implants and don't delay support. @CircAHA; @TuftsMedicalCtr; @ACCinTouch #Impella #ECMO #TandemLife #Shock @acurepublic

[AMCS Working Group @Tufts_AcuteMCS]

Shock Consensus Statement. After Culprit Shock, let's advance the success of Door to Balloon by exploring Door to Support times as a new approach to limit mortality due to cardiogenic shock. @CircAHA; @TuftsMedicalCtr; @ACCinTouch #Impella #ECMO #TandemLife #Shock