Turki Almalki MD,MSc,FRCPC

Msc Epidemiology @Mcgillu | Consultant Internal Medicine + Adult Clinical Immunology & Allergy @Mcmasteru & @psau_edu_sa

[ACR_Journals @ACR_Journals]

Is vitamin B3 (nicotinamide) effective for Raynaud phenomenon? A 6-week prospective, crossover study (n=38) of oral nicotinadmide 500mg BD resulted in improved PROMs in patients with primary RP but not in patients with SSc-related RP. Nailfold videocapillaroscopy patterns improved in both groups, but results should be interpreted with caution

ACROR
https://t.co/Jaba6bBrnL

[Waggoner Lab @LabWaggoner]

A randomized, placebo-controlled trial of 13-valent pneumococcal conjugate vaccination to accelerate immune recovery after sepsis [did not perform better than placebo]
https://t.co/OkmmSOnn5l @ScienceTM @KingsCollegeLon 🇬🇧

[RMD Open @bmj_rmdopen]

🎖️ Patients with immune-mediated inflammatory diseases face nearly double the risk of HPV-induced cancer
📊 French nationwide cohort: 122,316 IMID patients vs 316,047 matched controls (2016–2023)
📈 HPV-induced cancer or severe dysplasia: age-adjusted HR 1.99
⚠️ Elevated risk across cervical, vulvar, vaginal and anal sites (not penile)
🎯 Key risk factors: female (HR 5.88), SLE (HR 2.08), age <65 (HR 2.09), CKD (HR 1.44)
🔗 https://t.co/ZgnMgXojuA

[RMD Open @bmj_rmdopen]

🧬 First report of anifrolumab in ADA2 deficiency (DADA2)
👩 26-year-old initially diagnosed as SLE; atypical features (hypogammaglobulinaemia, B-cell lymphopenia, vanishing anti-dsDNA)
🧪 Homozygous class 5 missense CECR1/ADA2 variant confirmed DADA2
📉 Anifrolumab (anti-IFNAR1) induced rapid remission + major corticosteroid tapering
💡 Lower type I IFN score under anifrolumab — positions DADA2 near the type I interferonopathies

🔗 https://t.co/B9DgsFzfhR

[Waggoner Lab @LabWaggoner]

Review @NatRevRheumatol
Advances in targeting IL-1 family cytokines for the treatment of inflammatory diseases
https://t.co/wEi5K1FFcU

[RMD Open @bmj_rmdopen]

Disease-modifying treatment for #SjögrensDisease may finally be on the horizon

✅ Ianalumab and telitacicept have shown phase III success
✅ Nipocalimab, efgartigimod and dazodalibep have shown promising phase II results
✅ Emerging targets include BAFF/APRIL, FcRn, BTK, JAK/TYK2 and CD40–CD40L
⚠️ Improvement in dryness, fatigue and pain remains limited

🔓 https://t.co/FZ29FzTyw9

[Dr. John Cush @RheumNow]

New research shows synovial lining enriched in macrophages expressing SPP1 (encoding osteopontin) in proximity to fibroblasts and fibrin deposits. SPP1+ macrophages degrade fibrin & promote fibroblast proliferation that deposit collagen & does the damage, joint remodeling. A new potential target? https://t.co/BBRi1WN972

[مشبب بن علي العسيري @masiri1111]

أعلنت هيئة الغذاء والدواء الأمريكية عدم السماح باستخدام الصبغة الحمراء رقم ٣Red Dye no 3
لثبوت تسببها في السرطان لدى حيوانات التجارب .
وهذه الصبغة المصنعة غالبا من مواد بترولية تستخدم منذ زمن طويل في لاعطاء الحلويات والأدوية والمشروبات اللون الأحمر الجميل .
اذا وجدت اسمها في المكونات الغذائية فتجنبها وحذر اطفالك

[Science News @SciencNews]

The immune response

[وزارة الرياضة @mosgovsa]

سمو #ولي_العهد يشهد الحفل الختامي لبطولة #كأس_العالم_للرياضات_الإلكترونية📷 ويتوج الفائز بالمركز الأول فريق "فالكونز" السعودي. #ولي_العهد_في_EsportsWorldCup #حفل_التتويج_EsportsWorldCup #EsportsWorldCup📷

[Eddy J. Gutierrez, MD @eddyjoemd]

Approximately 30% of patients who undergo cardiac surgery develop acute kidney injury. Here are some mechanisms as to why it happens. 🎩 tip to the authors.

https://t.co/4Ise540F2X

[Saudi Arabia FIFA World Cup 2034™️ @Saudi2034]

Imagine the future with us in 2034! 💚

The #Saudi2034bid invites the world to join us on our journey of remarkable transformation as the home of global sport 🇸🇦 ⚽

Discover more: https://t.co/x8yAKWCwGE
#GrowingTogether

[Cristiano Ronaldo @Cristiano]

The @saudi2034bid invites the world to join us on our journey of remarkable transformation as the home of global sport 🇸🇦⚽️

#Saudi2034bid
#GrowingTogether

[واس الأخبار الملكية @spagov]

سمو #ولي_العهد يبارك استكمال المملكة للإجراءات النهائية لملف استضافة كأس العالم 2034 ... استعداداً لتسليمه للفيفا.
https://t.co/Y00YyAfe8h
#واس

[AAAAI @AAAAI_org]

#asthma

[أرامكو @saudi_aramco]

#على_العهد

نعِيش لَجْلِك فَرْض، ونموت لك فَرْض
معاهِدِين الدار شَعْب وقِيادَة 🇸🇦

#يوم_بدينا
#يوم_التأسيس
#أرامكو

[Misk Global @Misk_Global]

H.E. @AdelAljubeir, Minister @KSAMOFA, Member of the Council of Ministers &amp; Climate Envoy, commends the Kingdom of Saudi Arabia's progress, as well as the work of Saudi youth towards it.

#PoweredByYouth #TheBigNow #WEF24

[IMCrit @IM_Crit_]

The endless conflict between cardiologists and nephrologists:

[TOUR @sa_tourr]

هناك رياض واحدة فقط☝️🇸🇦..

الرئيس التنفيذي للدرعية جيري إنزيريلو، متحدثًا بفخر في لحظة تاريخية لوطننا الغالي،، لأن نكون محتضنًا لإكسبو 2030.

#الرياض_إكسبو2030

[Expo 2030 Riyadh @Expo2030Riyadh]

بلغاتٍ متعددةٍ.. وبرسالةٍ واحدةٍ بألسنةٍ تلهجُ ترحابًا؛ مرحبًا بكم في #الرياض_إكسبو2030! 🇸🇦
#الرياض_اختيار_العالم

Echoing a unified message in diverse languages and warm hospitality; welcome to #RiyadhExpo2030! 🇸🇦
#RiyadhTheWorldsChoice