PhD Candidate| Biochemistry Stanford University |Life is short. Smile while you have teeth #Rhythms of Grace #LivingaLegacy IG @tyfic_gh Facebook: Kwamina Nyame
Big News: Thrilled to share that my latest PhD work is now published in @Nature. We identify PLA2G15 as the lysosomal BMP hydrolase and show that blocking it improves outcomes in a severe neurodegenerative disease model. Read the article here https://t.co/dFZwLelCac (1/7)
#YearInReview Work led by @Tyfic_Gh & Jian Xiong in @abu_remaileh lab identified the enzyme PLA2G15 as a lysosomal degrader of BMP, a lipid that is misregulated in neurogenerative disease, providing a potential new access point for treatment: https://t.co/E4my8n7xWV
For neurodegenerative diseases like Alzheimer’s and Parkinson’s, treatment options are scant. New research identifies a promising access point to therapeutics.
https://t.co/UGfPzymXQ8
One of my favorite parts of this story is the behind the scenes where we were able to work with @abu_remaileh and @Tyfic_Gh on a second Pla2g15 paper. Science is great because it’s not isolated discoveries but validation by multiple groups.
https://t.co/v5ZUc7bQ8s
Work led by @Tyfic_Gh & Jian Xiong in the lab of Institute Scholar @abu_remaileh identified the enzyme PLA2G15 as a lysosomal degrader of BMP, a lipid that is misregulated in neurogenerative disease, providing a potential new access point for treatment: https://t.co/dHA7cwz0Mf
Big News: Thrilled to share that my latest PhD work is now published in @Nature. We identify PLA2G15 as the lysosomal BMP hydrolase and show that blocking it improves outcomes in a severe neurodegenerative disease model. Read the article here https://t.co/dFZwLelCac (1/7)
This project began with a serendipitous observation and grew through incredible mentorship, collaborations, and is also featured in Stanford News Report https://t.co/mPyAM1ZmdT
Thanks to co-first author @JianXiong19, @JudithSimcox, and the incredible team at Scenic Biotech.(6/7)
Thrilled to share that I’ve been awarded with the Knight Initiative for Brain Resilience Postdoc fellowship! Grateful to my wonderful mentor @abu_remaileh and @BrainResilience for this incredible support. Excited to continue advancing research in brain health and resilience!
Absolutely beautiful work @abu_remaileh and @Tyfic_Gh that will be important for #lysosomal storage disorders and in understanding the regulation of BMP lipids. Definitely a tour de force to probe lysosomal biology!
Excited to share our comprehensive work on BMP catabolism and truly grateful of the enjoyable journey of this discovery with my great science buddy Kwamina Nyame @Tyfic_Gh and my wonderful mentor Monther Abu-Remaileh @abu_remaileh
Very excited to share our recent discovery of PLA2G15 as a lysosomal BMP hydrolase whose targeting ameliorates lysosomal disease. We establish the rules that govern BMP catabolism, a key lipid implicated in multiple neurodegenerative diseases and lysosomal disorders
@abu_remaileh