Kwamina Nyame

PhD Candidate| Biochemistry Stanford University |Life is short. Smile while you have teeth #Rhythms of Grace #LivingaLegacy IG @tyfic_gh Facebook: Kwamina Nyame

[Kwamina Nyame @Tyfic_Gh]

Big News: Thrilled to share that my latest PhD work is now published in @Nature. We identify PLA2G15 as the lysosomal BMP hydrolase and show that blocking it improves outcomes in a severe neurodegenerative disease model. Read the article here https://t.co/dFZwLelCac (1/7)

[Sarafan ChEM-H @Stanford_ChEMH]

#YearInReview Work led by @Tyfic_Gh & Jian Xiong in @abu_remaileh lab identified the enzyme PLA2G15 as a lysosomal degrader of BMP, a lipid that is misregulated in neurogenerative disease, providing a potential new access point for treatment: https://t.co/E4my8n7xWV

[Wu Tsai Neurosciences Institute @StanfordBrain]

@karagm2009 @MargolisLabNYU @NYUPainResearch @nyuniversity @NYUDental @NYULH_DeptofMed @Westlake_Uni Kang Shen names the 2025 Sammy Kuo Awardees, starting with the grad student category.

Kwamina Nyame @Tyfic_Gh of the Abu-Remaileh Lab wins 3rd place for "PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease." https://t.co/jNkbyvDkro

[Stanford University @Stanford]

For neurodegenerative diseases like Alzheimer’s and Parkinson’s, treatment options are scant. New research identifies a promising access point to therapeutics.
https://t.co/UGfPzymXQ8

[Judith Simcox PhD @JudithSimcox]

One of my favorite parts of this story is the behind the scenes where we were able to work with @abu_remaileh and @Tyfic_Gh on a second Pla2g15 paper. Science is great because it’s not isolated discoveries but validation by multiple groups.

https://t.co/v5ZUc7bQ8s

[Sarafan ChEM-H @Stanford_ChEMH]

Work led by @Tyfic_Gh & Jian Xiong in the lab of Institute Scholar @abu_remaileh identified the enzyme PLA2G15 as a lysosomal degrader of BMP, a lipid that is misregulated in neurogenerative disease, providing a potential new access point for treatment: https://t.co/dHA7cwz0Mf

[Kwamina Nyame @Tyfic_Gh]

This work was done @Stanford @StanfordBiochem @Stanford_ChEMH @StanfordMed @StanfordEng, etc. Thanks to all funding sources, co-authors, and members of the Abu-Remaileh lab. There is hope to rescue neurodegeneration. (7/7) #Science #Jesus

[Kwamina Nyame @Tyfic_Gh]

Big News: Thrilled to share that my latest PhD work is now published in @Nature. We identify PLA2G15 as the lysosomal BMP hydrolase and show that blocking it improves outcomes in a severe neurodegenerative disease model. Read the article here https://t.co/dFZwLelCac (1/7)

[Kwamina Nyame @Tyfic_Gh]

This project began with a serendipitous observation and grew through incredible mentorship, collaborations, and is also featured in Stanford News Report https://t.co/mPyAM1ZmdT
Thanks to co-first author @JianXiong19, @JudithSimcox, and the incredible team at Scenic Biotech.(6/7)

[Kwamina Nyame @Tyfic_Gh]

Congrats @JianXiong19

[Jian Xiong (熊剑) @JianXiong19]

Thrilled to share that I’ve been awarded with the Knight Initiative for Brain Resilience Postdoc fellowship! Grateful to my wonderful mentor @abu_remaileh and @BrainResilience for this incredible support. Excited to continue advancing research in brain health and resilience!

[Judith Simcox PhD @JudithSimcox]

Absolutely beautiful work @abu_remaileh and @Tyfic_Gh that will be important for #lysosomal storage disorders and in understanding the regulation of BMP lipids. Definitely a tour de force to probe lysosomal biology!

[Jian Xiong (熊剑) @JianXiong19]

Excited to share our comprehensive work on BMP catabolism and truly grateful of the enjoyable journey of this discovery with my great science buddy Kwamina Nyame @Tyfic_Gh and my wonderful mentor Monther Abu-Remaileh @abu_remaileh

[Kwamina Nyame @Tyfic_Gh]

Very excited to share our recent discovery of PLA2G15 as a lysosomal BMP hydrolase whose targeting ameliorates lysosomal disease. We establish the rules that govern BMP catabolism, a key lipid implicated in multiple neurodegenerative diseases and lysosomal disorders
@abu_remaileh

[bioRxiv @biorxivpreprint]

PLA2G15 is a Lysosomal BMP Hydrolase with Ester Position Specificity and Its Targeting Ameliorates Lysosomal Disease https://t.co/Uzv3LTXxaA #bioRxiv

[Esther Sammler / Sammler lab @sammler_es222]

Super excited and out today: Tagless LysoIP method for molecular profiling of lysosomal content in clinical samples https://t.co/bnFytcuVm5

[Kwamina Nyame @Tyfic_Gh]

Excited and grateful for the opportunity to present at Bay Area Aging Meeting yesterday

[Long Lab @longlabstanford]

Now hearing @Stanford_ChEMH grad student @Tyfic_Gh presenting about lysosomal lipids at the Bay Area Aging Meeting @UCBerkeley @CarolynBertozzi @abu_remaileh

[Kwamina Nyame @Tyfic_Gh]

@UcheMedoh Congrats Uche! I know you’ll make great discoveries in your new endeavors