🚨 Excited to share our new paper in @LancetRespirMed 🚨
Our systematic review & network meta-analysis compares preoxygenation strategies for critically ill patients needing intubation. NIPPV tops HFNC & facemask in reducing hypoxaemia.
🔍 Study Highlights
• Systematic review & network meta-analysis of 15 RCTs (n=3420)
• Compared HFNC, NIPPV, and facemask oxygen for preoxygenation
• NIPPV likely best at reducing hypoxaemia during intubation
– vs HFNC: RR 0.73 (moderate certainty)
– vs facemask: RR 0.51 (high certainty)
• HFNC better than facemask: RR 0.69 (high certainty)
• No strategy improved first-attempt intubation success
• NIPPV may reduce serious adverse events vs HFNC/facemask
• No clear mortality difference between methods
• Data used to inform upcoming international airway guidelines
🧠 Implications: NIPPV may be preferred in high-risk or critically ill patients; findings support evidence-based guideline updates
https://t.co/rlIWdLUzWM
@UofT_DoM@MacDeptMed@Bram_Rochwerg@DenaZera@HEI_mcmaster
We’ve collapsed “AI” into “chatbot.” That is like pointing at a combustion engine and calling it physics. AI is a field, not a product.
My new piece maps the territory beyond the chat window: https://t.co/Yito1TSmzi #Ai#LLM#ML
I hope we can all reflect on how tragically stupid the @realDonaldTrump’s war on Iran was. Thousands dead, billions in destruction and for what? The crown gem of the 2 week ceasefire was the opening of the straights of Hormuz which was open the day before the war. #IranWar
"A significant fraction of the reporters covering the FDA and pharmaceutical industry have developed, over years of access journalism, a set of relationships and sympathies that align them more closely with the companies they cover than with the regulatory mission"
If you now want to switch off ChatGPT (for any reason 👀), here's your 15-minute migration guide.
No, you won't lose everything. No, it's not hard. And honestly? Starting fresh might be the best part.🧵
How many times will the USA drag the rest of the world into war? In my lifetime, there has been the Iraq war, the disaster in Libya, and Syria. Now we are being led to accept the atrocities in Gaza and blindfully accept an illegal war in Iran. The United States is unacceptable and no better than Russia in its wanton aggression. #Iran
How many times will the USA drag the rest of the world into war? In my lifetime, there has been the Iraq war, the disaster in Libya, and Syria. Now we are being led to accept the atrocities in Gaza and blindfully accept an illegal war in Iran. The United States is unacceptable and no better than Russia in its wanton aggression. #Iran
Two thoughts this morning:
The operation last night is an incredible testament to American pilots and other service members, from General Caine and General Kurilla on down.
While the media has attacked the president's senior team relentlessly, and tried to sow fake division, last night would have been impossible without perfect coordination and discretion from the president's national security team. I'm incredibly proud of them, and I know the president is, too.
NEW @bmj_latest research by @DenaZera and colleagues reviews evidence from randomised trials assessing the effectiveness of strategies to deprescribe benzodiazepines and closely related sedative hypnotics
https://t.co/LpCLEHgPnP
Excited to share our new paper in Intensive Care Medicine demonstrating the effectiveness of corticosteroids in community acquired pneumonia including new data from subgroups in ARDS and sepsis trials as well as the new REMAP-CAP trial. https://t.co/TB8wY1WW5r
@Bram_Rochwerg@EllenPauley@HEI_mcmaster@UofT_DoM@MacDeptMed
https://t.co/w4S5ZWZ0oJ