Gould Lab UCSF

Gould Lab studies roles of #BasementMembrane and #ECMatrix, and finds cures of a multi-system disorder #GouldSyndrome caused by mutations in #collagenIV.

[Gould Lab UCSF @UCSFGouldLab]

Today April 12th is #GouldSyndromeAwareness Day because this disease is caused by mutations in the Col4⃣ a1⃣ and a2⃣ genes. Please find your time to watch this 4 min video
👇👇👇
https://t.co/wmJuQb1arO via @YouTube

[Yoshi Ishikawa @yoshihiro0604]

Thank you for advertising our new preprint, Yutaka! 📢
If you are interested in prolyl 4-hydroxylation and collagen biosynthesis, you can learn how these go in Drosoplia ‼️🪰🪰🪰
Happy Friday 😎

[Yoshi Ishikawa @yoshihiro0604]

Please add your reading list! Our shiny collagen IV paper is out now😎 Enjoy beautiful red and green images! Yes, I MUST do molecular characterization of this "beauty" collagen IV... My TO-DO list is too much😅
@UCSFGouldLab

[Yoshi Ishikawa @yoshihiro0604]

My first post of 2025 is here! 😎 Excited to share my new paper on horse collagen I 🐎. We explored COL1 structure and modifications in horses with LH1 mutations. Don’t miss the unique images of twisted collagen fibrils—check it out below!👇👇👇

[UCSF Bakar Aging Research Institute @UCSFAging]

Interesting collaboration coming from the @UCSFGouldLab and @TamaraAlliston lab to identify an unexpected role of #collagen type IV in bone biology in connection with #TGFβ https://t.co/q0dzEwK7We

[UCSF Musculoskeletal Center @ucsfmskcenter]

Want to learn about #GouldSyndrome? Check out this month's featured #CCMBM #MSK member publication from @UCSFGouldLab & @TamaraAlliston: "Skeletal pathology in mouse models of Gould syndrome is partially alleviated by genetically reducing TGFβ signaling." https://t.co/Pmj4Y83lfj

[Gould Lab UCSF @UCSFGouldLab]

@xinduan @ucsfmskcenter @TamaraAlliston Thank you for letting us know, Xin!
Please check this link 👇👇
https://t.co/P1iVp1C9sC

[Gould Lab UCSF @UCSFGouldLab]

Check out our new publication!

[IOVS Journal @ARVOiovs]

Douglas Gould @UCSFGouldLab et al. investigate whether TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage, https://t.co/qmWt2AHr8t.

[Hiromi Yanagisawa @HYanagisawaLab]

We are please to announce Drs. Yoshi Ishikawa @yoshihiro0604 and Masashi Yanagisawa as the Luncheon Seminar speakers at #JSMBM24. 日本結合組織学会大会のランチョンセミナーはUCSF のYoshi Ishikawa 先生によるコラーゲンのフォールディング、Masashi Yanagisawa 先生による睡眠の講演です！

[Rachel Lennon @RLWczyk]

What an incredible first day at the #Alportworkshop on #WorldKidneyDay - so much has happened in the last 10 years & always so good to catch up with #basementmembrane friends ❤️@JeffMinerPhD @UCSFGouldLab @SherwoodElegans @stramerlab

[Gould Lab UCSF @UCSFGouldLab]

Exciting news! Our new research paper is published! This exciting study was done with a amazing collaborator Scott Early (@vesselman) lab. Congratulations🎉🍻🥳

[Science Signaling @scisignal]

In a model of #GouldSyndrome, researchers connect brain lesions and hemorrhages to disruptions in #CalciumSignaling in smooth muscle cells from misfolded collagen, impairing vessel’s ability to regulate cerebral blood flow. @UCSFGouldLab @CobreUnr https://t.co/17slEtfvoF

[Gould Lab UCSF @UCSFGouldLab]

#GouldSyndrome had great chemistry with #AlportSyndrome and basement membrane researchers at #ASMB2023! It is important to know each other, exchange ideas, and discuss future collaborations in person. I and @yoshihiro0604 are happy to be in this picture! Join Collagen IV biology!

[Jeffrey H. Miner @JeffMinerPhD]

Charismatic #AlportSyndrome and basement membrane researchers at #ASMB2023 @amsocmatbio enjoying some "networking time" together after a full day of scientific sessions in SLC. Thanks to @AlportSyndFndn for generously supporting the conference! @RLWczyk @BoudkoSergei @RW_Naylor

[Gould Lab UCSF @UCSFGouldLab]

@RLWczyk @yoshihiro0604 @AlportSyndFndn @MychelMorais1 @MarylineFresqu1 Great picture! Thank you! 😊

[ASMB @amsocmatbio]

Looking for another exciting #ECMatrix conference before our biennial meeting? Check out the #Collagen #GordonConference, where our very own ASMB council member Doug Gould @UCSFGouldLab is vice-chair! 👇
https://t.co/AGW1QFYTvR

[Gould Lab UCSF @UCSFGouldLab]

We appreciate that someone like our study and share it with Twitter community! Thank you!

[NAVBO @vascularbiology]

#NAVBO Member Publication Alert

Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in #GouldSyndrome

Dr. Scott Earley group @PNASNews 2023 @UCSFGouldLab @vesselman
https://t.co/vwODQu8HDs

[Gould Lab UCSF @UCSFGouldLab]

Beautiful work Earley lab! What a great collaboration!

[Scott Earley @vesselman]

Our latest preprint provides proof of concept for the use of PI3K inhibitors to treat vascular dementia. @UCSFGouldLab @unrmed @DoctorMC_

PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease https://t.co/yoEeXWUROv

[Gould Lab UCSF @UCSFGouldLab]

Please check this latest publication we involved about Gould syndrome! Great work and excellent collaboration! Cheers! 👍🎉

[Scott Earley @vesselman]

Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in Gould syndrome | Proceedings of the National Academy of Sciences https://t.co/UA7dFEyLjb
Check out out latest paper, part of an amazing collaboration with @UCSFGouldLab !

[Gould Lab UCSF @UCSFGouldLab]

Check our new paper!! Thank you @Xiaowei71 😊

[Xiaowei Wang @Xiaowei71]

check out recent work from @UCSFGouldLab on how Col4 is involved in vascular function through TGFb pathway. New insights for vascular pathologies including CSVD and @GouldSyndrome AddThis | Home https://t.co/7AUsGZBHtR

[Gould Lab UCSF @UCSFGouldLab]

@yoshihiro0604 Congratulations Yoshi!

[Gould Lab UCSF @UCSFGouldLab]

Congratulations to Danielle @RyansMom2, Sheena, and everyone with @GouldSyndrome

[Danielle Reinhart @RyansMom2]

I am so proud to share the very first manuscript out of the @GouldSyndrome Global Registry! @SheelMd @UCSFGouldLab @LisaMarieShank https://t.co/RQ9SOrwATb