Dr. Ankita Leekha from the @UH_NVLab led the development of NanoSTING 🦂, a nanoparticle formulation of the endogenous STING agonist, 2′−3′ cGAMP, to function as an immune activator and demonstrated its safety in mice and rats. 🐁 🐀
More here: https://t.co/bspSBG4m1e
Many congratulations to our Dr. Sunil Acharya @sunilacharya13 for his exciting research on CD70-targeting CAR NK cells, published in Cancer Discovery! Sunil and his co-authors showed that the incorporation of CD28 costimulation, which is normally absent in NK cells, in the CAR construct improves efficacy of CAR NK cells via the LCK/CD3ζ/ZAP70 pathway. Sincere thanks to our collaborators for their invaluable contributions. We’re excited about the promising clinical trials ahead! @MDAndersonNews #CancerResearch #Immunotherapy #CAR_NKCells @kchenken@UH_NVLab
CD28 co-stimulation in NK cells? Who knew! New @CD_AACR paper from @lab_rezvani@MDAndersonNews showing CD28 costimulation can augment CAR signaling in mature NK cells via the LCK/CD3Z/ZAP70 axis.
https://t.co/aIZ8d2Bns6
Team of #cancer researchers, led by @UHouston, discovered new #Tcells that may improve outcome for patients treated with T-cell therapies, especially those suffering from #lymphoma.
#lymphoma https://t.co/Epi6bf9F12
Check out the latest articles @NatureCancer "Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling" https://t.co/45CYXfCjDA
Dynamic functional profiling of T-cell therapies uncover a subset of T cells, labeled CD8-fit, that are motile serial killers and are associated with clinical responses in diffuse B cell lymphoma patients.
https://t.co/xr9jHn8P1Z
(No Paywall) https://t.co/KSAVlNoPSK
Understanding redundancies in cytotoxic mechanisms employed by CAR T cells in the killing of tumors @UHEngineering@UH_ChBE
Link: https://t.co/ukdHsjRwSJ
Celebrating the induction of four of my @UHouston colleagues as senior members of the National Academy of Inventors. Congratulations Navin Varadarajan, @tjmountziaris, James Briggs and Gomika Udugamasooriya
Linking extracellular vesicle (EV) secretion to metastasis at the single-cell level
@MohsenFathi1993@UH_ChBE@iScience_CP
iScience article: https://t.co/XHor3oogvI
(1/2) This issue of #Parameters features stories on @UH_ChBE Prof. Gül Zerze's academic path; new grants for @UH_NVLab (immunotherapy) and @ekourent (diagnostics); an ASEE award for postdoc Dr. LeShorn Benjamin (with @dr_jah_director); awards for Profs. Anil Bhowmick, ...
Incredibly proud of Ye Ethan Li for having his PhD project published in Nat Med. His paper shows that trogocytosis drives relapse post CAR NK therapy & that modulating NK signaling can improve CAR NK efficacy. Congratulations Ethan! @KenChen@UH_NVLab
https://t.co/Wtpc3dWtPG