Emilio Lecona's Lab

Account of the Chromatin, cancer and the ubiquitin system lab, based in the CBM. Focus on DNA replication dynamics, ubiquitin, SUMO and cancer.

[Emilio Lecona's Lab @UbiSystemLab]

It was a great honor to host Keith Caldecott at the @CBM_CSIC_UAM
Thanks for a very inspiring talk.

[Centro de Biología Molecular Severo Ochoa @CBM_CSIC_UAM]

Hemos tenido el placer de recibir a Keith Caldecott en el CBM. Su charla abordó el papel de la actividad PARP en la reparación de roturas de ADN y su impacto en enfermedad humana, y los mecanismos clave para mantener la estabilidad del genoma y entender patologías asociadas.

[Emilio Lecona's Lab @UbiSystemLab]

We propose a semi-distributive model for priming in the lagging strand that sets the RSR in a DNA replication control mode (DRC). The DRC modulates the progression of DNA replication through S phase to ensure the maintenance of genomic stability.

[Emilio Lecona's Lab @UbiSystemLab]

Fresh from the oven! Our new perspectives article where we discuss the interplay between lagging strand DNA replication and the replication stress response.
An updated view on lagging strand DNA replication: implications for the replication stress response https://t.co/eHFtHG4r7w

[Emilio Lecona's Lab @UbiSystemLab]

There is still time, contact us if you are interested

[Emilio Lecona's Lab @UbiSystemLab]

We are looking for a candidate to apply for a postdoctoral contract in the Juan de la Cierva 2025 call, to join our lab at the @CBM_CSIC_UAM to work on the interplay between the ubiquitin pathway, DNA replication and the replication stress response.

[Emilio Lecona's Lab @UbiSystemLab]

Congrats Alicia on the best poster prize in the PhD & Postdoc Annual Meeting @CBM_CSIC_UAM
Very proud of you! Many more successes to come!

[Emilio Lecona's Lab @UbiSystemLab]

We are looking for a candidate to apply for a postdoctoral contract in the Juan de la Cierva 2025 call, to join our lab at the @CBM_CSIC_UAM to work on the interplay between the ubiquitin pathway, DNA replication and the replication stress response.

[Emilio Lecona's Lab @UbiSystemLab]

#JDC2025

[Emilio Lecona's Lab @UbiSystemLab]

We are looking for a candidate to apply for a postdoctoral contract in the Juan de la Cierva 2025 call, to join our lab at the @CBM_CSIC_UAM to work on the interplay between the ubiquitin pathway, DNA replication and the replication stress response.

[Agencia Estatal de Investigación @AgEInves]

Aprobada la convocatoria Juan de la Cierva 2025 (#JDC2025) para fomentar la incorporación de jóvenes doctores/as y completar su formación postdoctoral en centros de I+D.
▶️500 ayudas
💵60 M€ (+21,7 M€ que 2024)
📅Plazo: 25 nov-10/17 dic 2025

📰https://t.co/lA3HGPYM8w

#FSE+

[Emilio Lecona's Lab @UbiSystemLab]

If you are interested, contact us!

[Cesar Cobaleda @CJCHCM]

Postdoctoral Position in "Molecular Mechanisms
of Childhood Leukemia Development" at CBM, Madrid @CBM_CSIC_UAM

[Fundación BBVA @FundacionBBVA]

🎉👏🏅¡Enhorabuena a los galardonados con los Premios a Jóvenes Investigadores Fundación BBVA-@SEBBM_es!

Consulta la lista de los premiados:
📰https://t.co/0VjrSDjbfJ

[Emilio Lecona's Lab @UbiSystemLab]

Very proud of @rodrimartinr showing his work his awesome work.

[SEBBM @SEBBM_es]

Regulation of DNA replication and the replication stress response by ubiquitin and VCP/p97 por @rodrimartinr de @UbiSystemLab @CBM_CSIC_UAM #47congresoSEBBM

[RepliFate @FateRepli]

Another exciting research article from a member of the #RepliFate network!

The @altmeyerlab identified the CNOT1-CCR4-NOT complex as a multi-level suppressor of the 53BP1-p53-p21 signaling axis.

Check out their findings here: https://t.co/1uO6kmaOYM

[Emilio Lecona's Lab @UbiSystemLab]

Still looking! Please spread the word.

[Emilio Lecona's Lab @UbiSystemLab]

We are looking for a candidate to apply to a #MSCA Postdoctoral Fellowship in our lab in the @CBM_CSIC_UAM, working on the connections between DNA replication dynamics, replication stress and genomic instability in cáncer. Contact us if you are interested and please retweet.

[Emilio Lecona's Lab @UbiSystemLab]

We are looking for a candidate to apply to a #MSCA Postdoctoral Fellowship in our lab in the @CBM_CSIC_UAM, working on the connections between DNA replication dynamics, replication stress and genomic instability in cáncer. Contact us if you are interested and please retweet.

[Emilio Lecona @Emlecona]

Muchas gracias por destacar nuestro trabajo en el @UbiSystemLab liderado por @rodrimartinr y en colaboración con @SaraRodriguezAc en el @JMendez_DNA lab.

[Emilio Lecona's Lab @UbiSystemLab]

@devega_M @CBM_CSIC_UAM @Emlecona @JMendez_DNA @CNIOStopCancer @SaraRodriguezAc @rodrimartinr @SMOA_CBM Thanks!!!

[Emilio Lecona's Lab @UbiSystemLab]

Fresh from the oven! Ever wondered how cells keep ATR activation controlled during normal DNA replication? Our last paper in @NatureComms shows that they do it by extracting POLA/PRIM from chromatin using VCP/p97! Still curious? Take a look...🧵🧵🧬🧬

[Emilio Lecona's Lab @UbiSystemLab]

@Emlecona @CBM_CSIC_UAM @JMendez_DNA @CNIOStopCancer @SaraRodriguezAc @rodrimartinr Huge thanks to all people involved, @SMOA_CBM and flow cytometry facilities from @CNIOStopCancer and @CBM_CSIC_UAM.

[Emilio Lecona's Lab @UbiSystemLab]

So, to sum up: VCP/p97 ➡️ POLA/PRIM on chromatin ➡️ priming ➡️ basal RSR activation! This work was led by @Emlecona from @CBM_CSIC_UAM in collaboration with @JMendez_DNA from @CNIOStopCancer. Want to dive a little bit more in our work? Click this link! https://t.co/I9LPzRK6Js