Vincent Dion

Professor @UKDRI at @CardiffUni working on gene editing for the treatment of expanded CAG/CTG repeat disorders. #Huntingtonsdisease, #DM1.

[Vincent Dion @VDion_and_Lab]

Our new manuscript is online!
Cas9 nickase-mediated contraction of CAG/CTG repeats at multiple disease loci
https://t.co/SWi5SHyH9c

Giant team effort! Led by the incredible @Alvaro_MurilloB with more help from @mariahlelos, @lab_davidson, and many many more.

Here's a thread.

[Vincent Dion @VDion_and_Lab]

Manuscript update alert!

Correcting expanded repeats with the #CRISPR Cas9 nickase.

In the brain!
Of a #Huntington’s disease model!

With improvements to molecular phenotypes!

And rescued locomotion!

Massive effort led by @Alvaro_MurilloB

https://t.co/QwbrC33CDo

[Vincent Dion @VDion_and_Lab]

Ever wondered why there are interruptions in expanded repeats?

Here are our thoughts:

https://t.co/l5F49Ntw1p

(We think the answer is double-strand break repair)

PS: I’ve not been on here for a bit, but I needed to do some self promotion.

[Vincent Dion @VDion_and_Lab]

We are lucky to be among the funded projects (We’re in good company!)

We’re de-risking our gene editing approach for expanded repeat disorders (e.g. Huntington’s disease, myotonic dystrophy…).

One step closer to the clinic! https://t.co/UaKZancljS

[Natalie Connor-Robson @nlconnor_robson]

Are you a bioinformatician interested in neurodegeneration? If so we have an exciting opportunity for you to join the lab. You will be helping unravel the molecular mechanisms of Alzheimer's using multi omics datsets @UKDRI Cardiff. @demrescommunity https://t.co/uYPegSWq6a

[Vincent Dion @VDion_and_Lab]

@AdrianoAguzzi Been there, done that. It’s not realistic to think that CH will absorb any number of US scientists wanting to leave. That’s assuming they do want to leave. Because again, let’s remind people that moving countries is a massive undertaking that few will go through with.

[Vincent Dion @VDion_and_Lab]

If you are from abroad and/or you have already been thinking of leaving, this is a good push. But for the vast majority of people, going abroad is not a solution.

[Vincent Dion @VDion_and_Lab]

I’ll say it again because it is important. American scientists will not en masse leave the US.

This is for several reasons. Here are a few.

For those already on the fence, we are recruiting a new centre director.

https://t.co/G7pwqQ4OfJ

[Vincent Dion @VDion_and_Lab]

3) There are not enough science jobs for hundreds of Americans to suddenly go abroad.

4) This is a grass is greener on the other side idea. There are problems with the systems elsewhere also.

[Vincent Dion @VDion_and_Lab]

I did a podcast. On #huntingtonsdisease. And #geneediting. So have a listen!

https://t.co/zO9mYqKB6S

[Vincent Dion @VDion_and_Lab]

I’ll drop this link her for anyone fancying being recruited as the new centre director for the @UKDRI at Cardiff uni.

https://t.co/eP7hGmoxRe

[Vincent Dion @VDion_and_Lab]

Alright people, we need a new director.

We’re a fun bunch and we do outstanding science. #neurodegeneration #PD #Huntington #Alzheimers

For more info, see link below and/or DM me!

@UKDRI @neurosciencecu

https://t.co/TG5lat1etE

[Alvaro Murillo @Alvaro_MurilloB]

I am very honored to speak at the Xmas meeting at the @InstitutoCajal in the new @Ci2A_CSIC about the research we conduct in @VDion_and_Lab. Looking forward to connecting with amazing researchers and engaging in scientific discussions.
@UKDRI @cardiffuni @CSIC @SENC_

[Alvaro Murillo @Alvaro_MurilloB]

Looking forward to talking about my work at @VDion_and_Lab and meet fantastic researchers at @UBneuroscience
@HDAwareness2024 @EuroHuntington @AsociacionAVAEH @EHDN_News
@UKDRI
@cardiffuni
#Huntingtonsdisease #myotonicdystrophy1 #CRISPR

[Alvaro Murillo @Alvaro_MurilloB]

Looking forward to presenting my Pilot Grant project at @UKDRI Connectome. Many thanks to @VDion_and_Lab for his support and to all my collaborators @isaacs_adrian @DayneBeccano #ThomasMassey @mariahlelos
#HuntingtonDisease #CRISPR #TeamWork #neuroscience

[Vincent Dion @VDion_and_Lab]

@CejkaLab Sorry: correct link is here:

https://t.co/kGZVfeh2Ia

[Vincent Dion @VDion_and_Lab]

Our article on how Cas9 nickase induces contraction of expanded CAG repeats is published!

Go on, read it, you know you want to.

One step closer to the clinic! (But still some ways to go…)

https://t.co/ouz4fuYWEI

[Maria Spies, PhD (she/her) @maria_spies]

An important and exciting step towards counteracting DNA repeat expansions in clinical setting. Read the new Editor's choice paper from the @VDion_and_Lab in NAR Molecular Medicine

[Vincent Dion @VDion_and_Lab]

Correct link:

https://t.co/kGZVfeh2Ia