Grant Stewart

The Stewart lab has a long-standing interest in studying rare human diseases associated with defective DNA repair and/or abnormal DNA replication.

[Grant Stewart @GS_Lab_Bham]

Awesome collaboration with @SPJacksonGroup, Chris Carney and Soren Hough, understanding how inherited mutations in the MEAE E3 ubiquitin ligase causes disease by compromising HR-dependent replication fork protection/restart. https://t.co/ScWbwH37Ol

[Peter Ly @PeterLyLab]

Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)

https://t.co/SbshGhofN0

[Grant Stewart @GS_Lab_Bham]

Finally our collaborative paper on inherited mutations in the actin nulceating factor, DIAPH1, spear-headed by the Houlden lab, @RMaroofian, Valentina Galassi Deforie, @StephanieEfthy1 and Peter Arkwright, is out in Genetics in Medicine. https://t.co/5NaBJCwPYx

[Grant Stewart @GS_Lab_Bham]

@StaplesLab @HombreRRo Nice one Chris!

[Grant Stewart @GS_Lab_Bham]

@VSmitsLab Thanks for hosting me. Very enjoyable visit with two great people.

[Grant Stewart @GS_Lab_Bham]

Interested in inherited chromosomal instability syndromes and DNA repair? We are looking for an enthusiastic person to join the Stewart lab at the University of Birmingham as a senior technician. If you are interested, please have a look at the job advert: https://t.co/ViFtLEXZZl

[Grant Stewart @GS_Lab_Bham]

Great work by the Kitagawa lab about DONSON regulating centrosome duplication is finally out in Nature Comms

https://t.co/iIC4gvTQMW

[Grant Stewart @GS_Lab_Bham]

Great paper by the Vaziri lab about the role of RNF25 regulating the DDR independently of its E3 ligase activity!

https://t.co/zPcqS299n8

[altmeyerlab @altmeyerlab]

New work from the lab: Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling @CellReports. Congratulations to first author Antonio Galarreta and to all co-authors. https://t.co/WE2QHsIs0S. #Microscopy #RNAiScreen #Condensates

[Suyang Zhang @Zhang_Suyang]

A transcription balance required for genome stability 🧬⚖️

Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on ⁦⁦@NatureSMB⁩

#CryoEM #transcription https://t.co/BXgtzSF10A

[Grant Stewart @GS_Lab_Bham]

@PgGarcialab Well done. Lovely bit of work.

[Garcia lab @PgGarcialab]

Delighted to announce that our paper showing the generation of iPSc from a MDS patient & how CEBPA drives disease progression is finally out in Nature Comms! A big thanks to everybody involved & the great collaborators that have made it possible!
https://t.co/b36gicik6Y

[Molecular Cell @MolecularCell]

Online Now: The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells https://t.co/mwvSZOI6gZ

[Molecular Cell @MolecularCell]

Online Now: The DNA replication checkpoint limits Okazaki fragment accumulation to protect and restart stalled forks https://t.co/ndMq11bmO8

[andre nussenzweig lab @nussenza]

Cytarabine has been the mainstay for AML treatment. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side effect: https://t.co/1AvK5l8CD0. Work led by Jia-Cheng Liu, Donpgeng Wang, Elsa Callen and many terrific collaborators!

[The Blackford Lab @DrAndyBlackford]

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested, closing date: 27th June 2025.

More details here: https://t.co/j1iwqP9kQN

[Grant Stewart @GS_Lab_Bham]

Awesome paper from @SPJacksonGroup and @FrogWalterLab about USP37 and TRAIP regulating the replication response to topoisomerase inhibitors. Glad to be a part of it. https://t.co/xcL0nIThlA

[Ivan Ahel Lab @IvanAhelLab]

Our new paper describing the RNF114 protein as a reader of dual hydrid modification composed of ADP-ribose and ubiquitin (ADPr-Ub) we discovered a few years ago (collaboration with the lab of Gerbrand van der Heden van Noort)
https://t.co/iWjymR9A7i

[Grant Stewart @GS_Lab_Bham]

Proud to present our work identifying a role for DIAPH1 and gamma-actin in regulating DSB repair and how defects in this pathway give rise to human disease. Big thanks to everyone involved, especially Beth Woodward, Sudipta Lahiri and Anoop Chauhan. https://t.co/ZLC9Yo4EE4

[Grant Stewart @GS_Lab_Bham]

Great collaborative study just out in Nature Communications about RNF168 regulation by PIN1. https://t.co/CkgAbc3fzQ