Vipul Panchal

Researcher @Medofak_uib | former @Sciroi_IN| #AMR #structurebaseddrugdesign, #RNATargets, #smallmoleculetherapeitics, #DrugDiscovery, #antibiotics

[Shekhar Gupta @ShekharGupta]

Our #50WordEdit on Danish newspaper caricature of PM Modi

[Vipul Panchal @VNPanchal]

@swasrao For the rest, nothing can be trusted including shows at Islamabad!

[Vipul Panchal @VNPanchal]

@swasrao Iran has earlier said Strait of Hormuz IS NOT CLOSED (i.e, it is open) but the traffic must pass through channels determined by them; Iran now says Strait of Hormuz IS OPEN (i.e. it is not closed) but the traffic must pass through channels determined by them. (Courtesy: Sushant)

[Vipul Panchal @VNPanchal]

@SurbhiG6 Authorship order matters. Even when co‑first authors contribute equally to the experiments, one of them often takes the lead in writing and shaping the manuscript, which can justify their position in the order.
But I acknowledge that in some instances the orders are unjustified!

[Vipul Panchal @VNPanchal]

@mog_russEN We did did QQ o
Illumining

[Vipul Panchal @VNPanchal]

@mog_russEN

[Vipul Panchal @VNPanchal]

@anushkashrof24 Yes

[Vipul Panchal @VNPanchal]

Every morning to work, such beautiful scenery marks the beginning of the day.
It is really satisfying.

[Vipul Panchal @VNPanchal]

Excellent! Low cost and early detection alternatives are key to fight infection and save lives.

[CSIR, India @CSIR_IND]

https://t.co/XRtGRL2N7W

[Rishi Bagree @rishibagree]

Loud & clear message to the world !!!

[ᴋᴀᴍʟᴇsʜ sɪɴɢʜ / tau @kkstau]

PROPER 🦏
Dhurandhar is technically good cinema, but it is also pure, unadulterated, and unacceptable propaganda. You don't need to see the full 3.4-hour film to conclude that. I haven't. Now you have to hear me out before you go out to watch this piece of gratuitous gore wrapped in a spy thriller cover.

Aditya Dhar is an insidious bigot, proven by his deliberate choice to show Pakistan in a poor light. He could have chosen Mauritius, which has beaches where the lady spy could prance in a bikini. But no, he chose the lovely Lyari in Karachi. Do we not have kachchi aabadi in India?

My bigotry of low expectations is so profound that I patronisingly conflate 25 crore Indian Muslims with Pakistan, and by extension, Islam, and therefore, I cannot endorse this 'Islamophobia.'

​I must offer my disservice now by preemptively attributing motives to Dhar and questioning the existence of any cinema, however well-made, that my indoctrinated intellect can't easily process.

I haven't seen the film, and I hope I don't like it when I do. My review will follow, but for now, know this: This is not my India. This is not my Bollywood.

​Dear YRF, only your spy universe can salvage what is left of our nice little insulated universe. Please show an Indian spy making love with a terrorist-spy who has vowed a thousand cuts on India. Make love, not war. Peace and out. ♥️☮️♥️

I expect all like-minded global citizens to believe me and support me as I raise the heat in a already hot and fractured society. I will not allow Aditya Dhar to damage the fabric the threads of which I have been pulling so carefully as I pull the wool over your eyes.

Wait for my review where I will condemn the chutzpah of Dhar and pan his big outing after watching the film. Also, Yami shouldn't have married this man. She is a bigot too. Deepika shouldn't have married the nutcase who looks brilliant as the protagonist. She is a bigot too. Compromised by JP Nadda with a brand ambassador role. Also, anybody who watches this film is a bigot. Except the critic with a conscience, like me.

Rating: Dhurandhar gets 0 stars. It's an assault on our collective lack of conscience.

[Gabbar @GabbbarSingh]

> Terror strike happens

> Question security lapse

> Make it the central point, so that the lapse feels intentional

> Prepare ground to call it a false flag

> Look for reasons: AQI, Elections, Dogs etc

> Claim victimhood when people come after you, declare country unsafe

[Smita Prakash @smitaprakash]

Twist in the tale - the physician who was storing tonnes of explosive material in Faridabad in a mosque was using a car to transport weapons, and that woman is a doctor too. She is now in custody.
https://t.co/Kgp6RWAGke

[Aditya Raj Kaul @AdityaRajKaul]

J&K Police deserves most of the credit for exposing Jaish e Muhammad Module in Faridabad/Saharanpur/Srinagar. Imagine what 2900Kgs of Ammonium Nitrate could have done in New Delhi. Red Fort blast is a sad unfortunate reality. It could have been far worse. Credit where it is due.

[Soumya Swaminathan @doctorsoumya]

It should be the top priority of the govt - all arms will need to work together. Time for a Swachh Vayu mission - replicate the success of Swacch Bharat! Every dollar invested in #CleanAir gets 6$ of benefits, according to @WorldBank. @ADB_HQ @MoHFW_INDIA @moefcc @PMOIndia @UNEP

[Shashi Tharoor @ShashiTharoor]

I already have all these symptoms myself! As do so many around me. We need to clean up the national capital’s air on a war footing.

[Arindam Ghosh @ArindamPhysics]

This article in @Nature reinforced my long-held belief that when it comes to supervising PhD students, we in India need to deviate from our traditional approach to education and knowledge transfer. Supervising is not teaching. PhD students need to be treated as colleagues and intellectually independent, else their professional growth will remain incomplete.

[Vipul Panchal @VNPanchal]

@sangishyam This data only gives us the overall contribution. I would actually like to see the distribution or contribution of govt Vs private sector

[Vipul Panchal @VNPanchal]

6/
Finally we address these limitations by combining BLI with an orthogonal NMR assay.

[Vipul Panchal @VNPanchal]

Happy to share our work on evaluating suitability of BLI- a biophysical method, to identify RNA focused fragment based drug discovery.
https://t.co/3p5iAPVIdY

#DrugDiscovery #RNA #Biotech #FragmentScreening #BiolayerInterferometry

[Vipul Panchal @VNPanchal]

5/
While we identified new fragment binders for one of the RNA targets, the major limitation of BLI is 1) to obtain a sufficiently high signal-to-noise ratio and 2) to discriminate true binders from non-binders in a dose response assay, due to atypical response at > 50 μM.