V_alien

Vishal Nangalia, Anaesthesiologist, Medical Machine Learning Research and Real World Applications

[Alexander Khrebet @AlexKhrebet]

A #Russia's missile hits the building while a Ukrainian volunteer is asking for more help.
#Ukraine #UkraineInvasion

[Barry Malone @malonebarry]

Remarkable moment caught on camera as Zelensky hears about the bombing of the Babyn Yar Holocaust memorial for the first time.

[Shaun Walker @shaunwalker7]

Two presidents meet with their respective defence ministers.

[Kat Abughazaleh @KatAbughazaleh]

so apparently Zelenskyy won the Ukrainian version of Dancing with the Stars in 2006 and the tape is even better than whatever you're imagining

[Jyoti Nangalia @jyoti_nangalia]

9/ We have loved working on this and learnt so much. Thank you to the amazing Nick Williams! To all the team, Joe Lee, @luiza_moore, Anna Godfrey. To Peter Campbell and Tony Green. Our funders @CR_UK @mpnrf @EHA_Hematology and our dear patients.

[Jyoti Nangalia @jyoti_nangalia]

8/ Importantly, the rate of expansion of mutant-JAK2 predicted the time to MPN diagnosis..... a possibility of early detection and disease prediction? #stopcancer

[Jyoti Nangalia @jyoti_nangalia]

7/ Clone growth rates varied: <10%/yr to >200%/yr for multiply mutated clones. #JAK2V617F clones grew at different rates in different individuals - ie patient-specific factors (germline, environment) influence its consequences as shown by @bloodgenes lab and others.

[Jyoti Nangalia @jyoti_nangalia]

6/ Cancer driver mutations could occur sequentially - decades apart. Different orders including JAK2 mutations coming second. #clonalevolution

[Jyoti Nangalia @jyoti_nangalia]

5/ We found in utero and childhood acquisition of DNMT3A mutations too. In one patient, the #DNMT3A mutation was acquired within few weeks of conception – the start of life. Ageing per se didn’t drive such clonal haematopoiesis – it simply took an age for the clones to grow.

[Jyoti Nangalia @jyoti_nangalia]

4/ JAK2 mutations were acquired early in life - in utero and childhood despite a diagnosis many decades later, up to 54 years before MPN diagnosis for one patient #JAK2V617F

[Jyoti Nangalia @jyoti_nangalia]

3/ We used DNA mutations to trace the ancestral relationships between colonies - building a "family tree" of blood production for each patient. We could then time the cancer driving genetic events and trace how the mutant clones expanded over the patient’s life.

[Jyoti Nangalia @jyoti_nangalia]

2/ We took single blood cells from patients with MPN and grew each cell into a colony. We then sequenced each colony's whole genome (>950 whole genomes).

[Jyoti Nangalia @jyoti_nangalia]

1/ "How long have I had it for?"

Our patients with #bloodcancer have always wanted to know. We set out to answer it. We studied patients with MPN #mpnsm and found quite unexpected results. Excited to share our preprint https://t.co/elOrvlUIjL

[V_alien @V_alien]

Island Living 😁 @ Capri, Italy https://t.co/JIY4ICL4Uh

[De Kai @dekai123]

@JimmyDoreShow devotes a full episode https://t.co/eBkquhuzDB to #masks4all following @jeremyphoward's tweetstorm. From 9:45 to 12:20 @jimmy_dore presents our #UniversalMasking work at https://t.co/QJqgUc6e05 by @dekai123 @guypgoldstein @AlexeyMorgunov @V_alien @AnnaRotkirch

[De Kai @dekai123]

@nytimes interviews me on harmful culturally-driven unconscious biases against #UniversalMasking, and our work that "has modeled the potential for mass mask-wearing to significantly reduce infections" by @dekai123 @guypgoldstein @AlexeyMorgunov @V_alien @AnnaRotkirch #masks4all

[𝘈𝘯𝘢𝘦𝘴𝘵𝘩𝘦𝘴𝘪𝘢 @Anaes_Journal]

🔐Use of in situ simulation to evaluate the operational readiness of a high‐consequence infectious disease intensive care unit.

This excellent paper from @TajFregene, @jambuc33 and @v_alien is #FOAMed forever!

🔗https://t.co/w9TKS8ByMb

[𝘈𝘯𝘢𝘦𝘴𝘵𝘩𝘦𝘴𝘪𝘢 @Anaes_Journal]

🔐"The problems identified encompassed aspects of operational readiness of the ICU for admission of patients with COVID‐19. These included staff preparedness, equipment shortages and lack of tailored guidelines."

@TajFregene @jambuc33
@v_alien

🔗https://t.co/w9TKS8jXUD

[𝘈𝘯𝘢𝘦𝘴𝘵𝘩𝘦𝘴𝘪𝘢 @Anaes_Journal]

🔐This new in situ simulation study from @TajFregene, @jambuc33 and @v_alien shows how multiple operational deficiencies were found and corrected before the admission of the first patient with COVID-19 at high-consequence infectious disease ICU.

🔗https://t.co/w9TKS8ByMb