Vern Dolinsky

Professor and Co-lead of DREAM, the #Diabetes Theme @DREAM_diabetes at the Children's Hospital Research Institute of Manitoba @CHRIManitoba

[Vern Dolinsky @VernDolinsky]

Incretin hormones GLP-1 and GIP connect #metabolism and cardiovascular #health. Our new review highlights the latest about how endogenous incretins shape cardiometabolic disease @khushali_triv @cdnsciencepub @PhysiolPharma @UM_RadyFHS https://t.co/vw06bDM6n6

[Satchin Panda @SatchinPanda]

A new Hormone Cell Atlas maps where hormones are made and received across 47 human tissues using 14 million single cells. The resource reveals unexpected hormone-producing cells, endocrine feedback networks, and new insights into metabolic and endocrine disease. #Endocrinology #SingleCell #PrecisionMedicine
https://t.co/eP9lhXMoxg

[Vern Dolinsky @VernDolinsky]

Retrospective cohort study: Detection of young-onset type 2 #diabetes using deep learning across primary and secondary care: Nationwide study from Denmark (n=16828 youth-onset T2D population) @TheLancet https://t.co/QUAUdz7n3F

[Eric Topol @EricTopol]

The ramp up of cancer immunotherapy is remarkable. Now we're seeing vaccines achieve some cures or remissions in the most refractory cancers: pancreatic, melanoma, glioblastoma, renal, triple-negative breast cancer.
✓ out the new Ground Truths (link in profile)

[Vern Dolinsky @VernDolinsky]

REVIEW: #Metabolic syndrome and #kidney dysfunction: emerging molecular and cellular mechanisms at the metabolic–renal interface #mitochondria @FrontEndocrinol
https://t.co/AJac1Oxv6i

[Vern Dolinsky @VernDolinsky]

REVIEW: #Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for #diabetes https://t.co/pJM2jvwx1R

[Vern Dolinsky @VernDolinsky]

REVIEW: #Heart Failure in Type 1 vs. Type 2 #diabetes Shared Pathways, Distinct Challenges https://t.co/li1Xn7pPQW

[Vern Dolinsky @VernDolinsky]

REVIEW: #Proteomics of the #heart @physiolrev https://t.co/wrLhzuouGa

[Vern Dolinsky @VernDolinsky]

Functional validation of a non-canonical HNF1B splice-site variant in MODY5 #diabetes @FrontEndocrinol
https://t.co/LXUbxykLOW

[Vern Dolinsky @VernDolinsky]

Check out this interesting paper @DREAM_diabetes @DREAM_trainees #diabetes

[JCI insight @JCI_insight]

@Inserm Progressive HNF1A-MODY pathophysiology revealed by a translational mouse model: https://t.co/WahCOIliXw

[Vern Dolinsky @VernDolinsky]

Maternal #obesity alters adipogenic potential and #mitochondrial maximal respiration in infant mesenchymal stem cells #DOHaD @FrontEndocrinol
https://t.co/im2KQGGdQz

[Jeffrey Millman @JeffreyRMillman]

🚨Excited to share our single-cell multi-omic atlas of #stemcell islet differentiation that predicts cell fate decisions and identifies causal regulators of lineage specification. You can start browsing the data now 👉 https://t.co/zIQXlqjlbc Preprint 👉 https://t.co/7gLx7kr6bu

[Tanentzapf Lab @TanentzapfLab]

1. Our main biomedical funding body is telling Canadian PIs its review system is collapsing. 50% increase in applications (attributed to AI but really due to PIs dealing w/ is essentially a lottery). PIs declining to review due to fatigue from turning down so much awesome science

[Vern Dolinsky @VernDolinsky]

@mrlakin13 @JCI_insight Nice paper congrats

[Daniel J Drucker @DanielJDrucker]

The fascinating biology of targeting nuclear receptor ligands to GLP-1 receptor + cells continues, with the latest chapter studying GLP-1 E2 in NOD mice, with or without low dose aCD3 @DiabetologiaJnl https://t.co/dwXNWmlNwL

[Satchin Panda @SatchinPanda]

Blood NAD+ may not be the aging biomarker many hoped for.
Across 7 human cohorts, whole-blood NAD+ levels stayed remarkably stable with age and lifestyle changes—shifting mainly with nicotinamide riboside supplementation. #Aging #NAD #Longevity
https://t.co/BVXXJgT344

[Journal of Clinical Investigation @jclinicalinvest]

From earlier this week: A landmark in cardiac metabolism: https://t.co/65t2q5fBwb

Jay D. Horton & team @UTSWMedCenter find unrestrained fat oxidation in heart cells deplete cardiolipins that are needed for mitochondrial energy, triggering heart failure in mice and revealing a potential metabolic target.

The figure shows decreased heart function in cardiac-specific ACC1/ACC2 double KO (dHKO) mice.
#CardiacMetabolism #HeartFailure

[Daniel J Drucker @DanielJDrucker]

New advances in understanding the wide range in human islet cell heterogeneity and secretory phenotypes from the Integrated Islet Distribution Program (IIDP). The abundance of δ cells showed the strongest association with insulin secretion and #T2D
https://t.co/RBq4zEIhQw

[Satchin Panda @SatchinPanda]

Timing matters 🕒 For type 2 diabetes, afternoon/evening exercise boosts insulin sensitivity & glycemic control, while morning workouts may raise blood sugar. Later workouts are also linked to lower cortisol, less inflammation & better oxidative capacity. #Diabetes #ExerciseScience @WuTsaiAlliance
https://t.co/5Bc0PUAE9O

[Olga Lautman 🇺🇸🇺🇦 @OlgaNYC1211]

After Hungary, Putin and Trump’s overlapping influence operations have a new target. And this time it’s Canada.

My latest…
https://t.co/UOtgW0Y6c6

[Cell Metabolism @Cell_Metabolism]

Plasma proteomic signature of frailty in 50,506 adults https://t.co/8vEcwnU6QO