We just published our article on discovery of novel small-molecule ERBB4 agonists. https://t.co/Fx1Dr9feGe
Thx to Gilles De Keulenaer, Eline Feyen, Julie Cools, Bo Goovaerts, and many others
Case report: a diagnosis of left ventricular anterior free-wall rupture in a female patient with jaw pain, diagnosed with ST-elevation myocardial infarction, who developed sudden hemodynamic deterioration after administration of anticoagulant therapy. https://t.co/vD7jb7B8O0
We participated in @AtomwiseInc #AIMS study published in @SciReports highlighting #AtomNet as a viable alternative to high-throughput screening! Read about the largest and most comprehensive virtual HTS campaign to date: https://t.co/dSUKKYdywe #drugdiscovery#AI#pharma#biotech
The gut Cholesin-GPR146 axis mediates the inhibitory effect of intestinal cholesterol absorption on hepatic #cholesterol synthesis @CellCellPress https://t.co/CyPfQZyqWK
Excellent study in Science Translational Medicine demonstrating that cardiac endothelial contribute to cardiac fibrosis, both directly by production of extracellular matrix and indirectly by activation of fibroblasts.
https://t.co/jU058wy2x4
Amazing study in JACC: Multiomics Analysis Provides Novel Pathways Related to Progression of Heart Failure. https://t.co/s7tw4V12KT
And guess what? The most important pathway discovered in this unbiased study is the neuregulin/ERBB pathway.
Ellegant paper describing a screening experiment for molecules that modulate cardiomyocyte relaxation, while at the same time identifying EGFR/IGF1R Signaling as a new pathway regulating cardiac relaxation. Circulation Research https://t.co/0ZJgsC8UJT
Recruited macrophages elicit atrial fibrillation | Science https://t.co/0MlZTXTsuk Excellent study by Maarten Hulsmans and colleagues demonstrating the importance of recruited macrophages to development of Atrial fibrillation.
An argument to continue clopidogrel instead of aspirin monotherapy:
Aspirin vs. Clopidogrel for Chronic Maintenance Monotherapy after Percutaneous Coronary Intervention: the HOST-EXAM Extended Study https://t.co/aZUYgmjX7s