WarrenLeeLab

Endothelial Biologist. ICU Physician and Scientist.

[ATVB: An AHA Journal @atvbahajournals]

Check out the latest #ATVBnet post by @Y45900496Yu !
https://t.co/DiRDAVeITL

[WarrenLeeLab @WarrenLeeLab]

Agree with @MireilleOuimet. Really enjoyed CLVS2024! Great science and camaraderie.

[Mireille Ouimet @MireilleOuimet]

I had an incredible time at #CLVS 2024 in Blue Mountain! Outstanding scientific presentations, and it was so rewarding to reconnect with familiar faces and meet new friends. Already excited for the 2025 meeting in Saskatoon, the "Paris of the Prairies"😉! 📷Credit:
@PatriciaLiaw

[WarrenLeeLab @WarrenLeeLab]

Delighted that Erika Jang and Winnie Ho's latest work is out. LDL transcytosis across the endothelium is the first step in atherogenesis, typically involving caveolin-1 and SR-BI or ALK1. We describe a distinct route that uses LDLR and Rab27a in response to pM levels of IL-1b.

[ATVB: An AHA Journal @atvbahajournals]

IL-1B accelerates atherosclerosis by inducing LDL transcytosis independently of caveolin-1. The pathway requires LDLR and Rab27a @WarrenLeeLab @TseWingWinnieHo

https://t.co/uLpSQUQ4Ub

[ATVB: An AHA Journal @atvbahajournals]

IL-1B accelerates atherosclerosis by inducing LDL transcytosis independently of caveolin-1. The pathway requires LDLR and Rab27a @WarrenLeeLab @TseWingWinnieHo

https://t.co/uLpSQUQ4Ub

[Circulation Research @CircRes]

Kothari et al found that large #HDL particles hinder #LDL endothelial #transcytosis. Read more about the implications for #CVD risk in type 1 #diabetes at https://t.co/OpbHQfizZZ

@BornfeldtKarin @KanterJenny @warrenleelab @TseWingWinnieHo @wobbrockjo

[Greg Fairn @gfairn]

ApoAI/HDL binds and competes with LDL for SR-BI on endothelial cells, thereby partly reducing LDL transcytosis. Yet another way “good” cholesterol is beneficial. The last work from Karen Fung’s thesis and collaboration with my former neighbor @WarrenLeeLab

[Kathryn Howe @kat_howe]

Directional Endothelial Communication by Polarized Extracellular Vesicle Release | Circulation Research Congrats ⁦@SnehaRajuMD⁩ et al! Wonderful work from many labs ⁦@kat_howe⁩ ⁦@FishLab_UHN⁩ ⁦@AikawaElena⁩ ⁦@WarrenLeeLab⁩ https://t.co/WBkBsXVGjz

[Pablo Corral MD @drpablocorral]

☝️Must read

👉LDL Transcytosis by the Arterial Endothelium—Atherosclerosis by a Thousand Cuts?

😉Inflammation stimulates LDL transcytosis

🤔Identifying the function and mechanisms of LDL transcytosis may ultimately permit its therapeutic manipulation

https://t.co/EcYOZLivKK

[AJP-Lung Cellular and Molecular Physiology @AJPLung]

Today we feature a #ShortReport in our #ArticleinPress by Rajiv Sanwal et al. #Ultrasound-guided transfection of claudin-5 improves lung endothelial barrier function in #LungInjury without impairing innate immunity:

https://t.co/uIGwMjj7ZP

@iBESTResearch @UnityHealthTO @UofT

[WarrenLeeLab @WarrenLeeLab]

Excited to share our work describing targeted transfection of injured lung. A huge effort by @RajivSanwal and collaborators. Over-expression of claudin-5 using ultrasound & microbubbles decreased vascular leakage w/o impairing innate immunity.
https://t.co/31CPdiCFmY @AJPLung

[WarrenLeeLab @WarrenLeeLab]

Thanks to our terrific collaborators including @TorresVJ_Lab, @Kat_howe, @FishLab_UHN and Andras Kapus.

[WarrenLeeLab @WarrenLeeLab]

Endothelial ACKR1 is induced by neutrophil contact and down-regulated by secretion in extracellular vesicles https://t.co/MYHvtpDmUA

[WarrenLeeLab @WarrenLeeLab]

Duffy antigen receptor for chemokines (DARC) or ACKR1 is expressed on endothelial cells in tissue but the protein is lost when cells are cultured. Here we report how to induce endothelial ACKR1 and how it is regulated. Congrats to Xinying Guo and @KhNegar for figuring this out!

[Pharmaceutics MDPI @MDPIpharma]

#MDPIPharmaceutics
"Plug and Pop: A 3D-Printed, Modular Platform for Drug Delivery Using Clinical Ultrasound and Microbubbles" by Kushal Joshi et al.

Full paper at：https://t.co/dtUIYxxitv

[WarrenLeeLab @WarrenLeeLab]

Lab picnic on the island. Fun but a bit chilly; maybe should have done it before the CIHR deadline...

[WarrenLeeLab @WarrenLeeLab]

First in-person conference in over two years. The students did a great job representing the lab! @GordonConf

[Tessa Davis @TessaRDavis]

Of all the meeting platforms we've used over the last 2 years, Zoom is the one I love most.

Most of us think we know Zoom inside out.

But we don't.

Here are 7 Zoom hacks you probably haven't heard of, but you'll be glad you now know.

🧵👇

[WarrenLeeLab @WarrenLeeLab]

Grateful for the renewal of my Canada Research Chair. And especially thankful to my terrific students and techs who make research so much fun!

[Unity Health Toronto @UnityHealthTO]

Three scientists at St. Michael’s Hospital have received prestigious research chair awards from @CIHR_IRSC and @CRC_CRC. Congratulations to Dr. @AndrewDPinto, Dr. @ATricco and Dr. @WarrenLeeLab! Read more: https://t.co/RclUcHme91