Jason Fish

Vascular biologist at University Health Network

[Anthony Gramolini @A_Gramolini]

1/2
Very proud of Omar Hamed & the entire team! Our new @NatureCVR paper is out, with a terrific News & Views by @AliciaLundby.

Fantastic, longstanding collaboration with @FilioBillia and a huge group effort!

https://t.co/aDHR4YsefG

#HeartFailure #Proteomics

[Milica Radisic @milicaruoft]

More about the heart's hidden shield against cancer https://t.co/VWEpK5RPxQ @AmidShakeri @NatureComms @FishLab_UHN @UHN_Research

[Marwan Abid Althagafi مروان عابدالثقفي @abid_marwan]

8 years of work. Finally published.

Our paper in @CircRes shows that arterial resident—but not monocyte-derived—macrophages require endothelial CSF1.

Grateful to everyone who made this journey possible. @UHN @UofT_LMP

🔗 https://t.co/63AVaht78l

#atherosclerosis

[Chiara Giannarelli @ChiaraGiannare1]

1/5 What if an existing rheumatoid arthritis drug could help target the plaque biology that drives heart disease, not just cholesterol?
Using a human arterial-wall gene network and NIH LINCS drug data, we identified auranofin as a top candidate for atherosclerosis.

[UHN Research @UHN_Research]

New research from @UHN’s @PMunkCardiacCtr shows that the protein ERG helps protect blood vessels from changes that drive atherosclerosis—the buildup of plaque in the arteries. Findings could point to future therapeutic strategies to protect arteries.

🔗: https://t.co/bDjVFgD5AX

[Kathryn Howe @kat_howe]

Reposting - our new story - now available for all! Open access. https://t.co/S1laxKMlUv Thank you @NatureComms for the incredible editorial work and review process. Hard work that led to a transformative paper! Congrats team @SRBotts @kat_howe @FishLab_UHN

[Kai Wang @KaiWang_PKU]

Glad to share our recent paper published
@ScienceAdvances
ETV2 is the initiator of the offense, and TAL1 is the setter; together they sweep through the field, and neither can be missed. What's even more intriguing is that its function is not entirely conserved across species.

[Jason Fish @FishLab_UHN]

@husam247 @CIHR_IRSC @WCHospital @PMunkCardiacCtr @uoftmedicine Congrats!

[Steven Botts @SRBotts]

#EndothelialDysfunction is a critical driver of #atherosclerosis, but how can EC identity be preserved to limit plaque progression?

Thrilled to share my final PhD work in @NatureComms: https://t.co/9c3bzPaUx0

@kat_howe @FishLab_UHN @PMunkCardiacCtr @UHN_Research @UofTVascular

[Steven Botts @SRBotts]

Very excited to share chapter 1 of our endothelial identity story out now in @GenomeMedicine !!

Here we show that ERG governs dynamic and reversible EndMT in arterial ECs to limit endothelial dysfunction: https://t.co/mAoj0nuaXV

@FishLab_UHN @kat_howe @Kristen_ESchulz

[Jason Fish @FishLab_UHN]

Work was led by Ruilin Wu with collaboration with Negar Khosraviani, Ann Mansur, Kathryn Howe, Ivan Radovanovic, Josh Wythe and many others. @UHN

[Jason Fish @FishLab_UHN]

Very excited about this study in @EmboMolMed, where we show that KRAS mutations drive glycolytic reprogramming of the endothelium in sporadic brain arteriovenous malformations. We show a synergistic impact of targeting glycolysis and MEK. https://t.co/ZlI2HmTUKn

[Steven Botts @SRBotts]

Thank you @kat_howe and @FishLab_UHN !! It was an absolute pleasure completing this journey with your guidance and support. Very excited to share our research story in the days ahead!

[JACC Journals @JACCJournals]

#CTRCD may be identifiable before therapy begins. In #HER2+ #breastCA pretreatment endothelial & inflammatory biomarkers: ANGPT2, MPO, & endoglin, outperformed clinical & CMR in predicting cardiac dysfunction https://t.co/ZTkWXSjiRQ

#JACCCardioOnc #BCsm @dineshpmcc1 @FishLab_UHN

[Kathryn Howe @kat_howe]

Yep 👇this is what it’s all about! Come work with us at https://t.co/OeswVF7UNi @FishLab_UHN @kat_howe So many great endothelial centric stories. Keen on vascular biology? Cool cellular communication? Cell identity? Novel therapeutic strategies? 😎UHN Canada Leads filling fast!

[dineshpmcc @dineshpmcc1]

Exciting work by @FishLab_UHN using #cardioncology cohorts @PMunkCardiacCtr / combined blood biomarkers approach to predict #CTRCD @JACCJournals even before cancer therapy. Reach out if u have banked blood for additional external validation.@ICOSociety @CCardiacON @UHN @UofT

[Jason Fish @FishLab_UHN]

Excited to share our paper https://t.co/qDpeJLoyUg. Together with @dineshpmcc1 and led by Dakota Gustafson and Priya Mistry, we show that elevated levels of inflammatory and endothelial activation biomarkers before treatment can predict cancer therapy-related cardiac dysfunction.

[Stephanie Protze @StephIrisPro]

So excited to share the first paper from the lab!
We identified CD34 as a marker of the heart’s SAN pacemaker cells enabling their isolation from stem cell differentiation cultures, advancing future disease modeling and biological pacemaker applications.
https://t.co/yaThtPS3WC

[UHN STEM Pathways @UHNSTEMPathways]

We're back with another PA Day at UHN! We have two exciting sessions today with students from schools across the GTA coming in to explore #STEM. Stay tuned for some fun snapshots. 💡

[Banting & Best Diabetes Centre @BBDC_UofT]

On #WorldDiabetesDay we celebrate the next generation of diabetes researchers - like Cori Lau from @FishLab_UHN. Cori shares why diabetes research matters to him. #WDD2024