Jason Fish

Vascular biologist at University Health Network

[Steven Botts @SRBotts]

Very excited to share chapter 1 of our endothelial identity story out now in @GenomeMedicine !!

Here we show that ERG governs dynamic and reversible EndMT in arterial ECs to limit endothelial dysfunction: https://t.co/mAoj0nuaXV

@FishLab_UHN @kat_howe @Kristen_ESchulz

[Jason Fish @FishLab_UHN]

Work was led by Ruilin Wu with collaboration with Negar Khosraviani, Ann Mansur, Kathryn Howe, Ivan Radovanovic, Josh Wythe and many others. @UHN

[Jason Fish @FishLab_UHN]

Very excited about this study in @EmboMolMed, where we show that KRAS mutations drive glycolytic reprogramming of the endothelium in sporadic brain arteriovenous malformations. We show a synergistic impact of targeting glycolysis and MEK. https://t.co/ZlI2HmTUKn

[Steven Botts @SRBotts]

Thank you @kat_howe and @FishLab_UHN !! It was an absolute pleasure completing this journey with your guidance and support. Very excited to share our research story in the days ahead!

[JACC Journals @JACCJournals]

#CTRCD may be identifiable before therapy begins. In #HER2+ #breastCA pretreatment endothelial & inflammatory biomarkers: ANGPT2, MPO, & endoglin, outperformed clinical & CMR in predicting cardiac dysfunction https://t.co/ZTkWXSjiRQ

#JACCCardioOnc #BCsm @dineshpmcc1 @FishLab_UHN

[Kathryn Howe @kat_howe]

Yep 👇this is what it’s all about! Come work with us at https://t.co/OeswVF7UNi @FishLab_UHN @kat_howe So many great endothelial centric stories. Keen on vascular biology? Cool cellular communication? Cell identity? Novel therapeutic strategies? 😎UHN Canada Leads filling fast!

[dineshpmcc @dineshpmcc1]

Exciting work by @FishLab_UHN using #cardioncology cohorts @PMunkCardiacCtr / combined blood biomarkers approach to predict #CTRCD @JACCJournals even before cancer therapy. Reach out if u have banked blood for additional external validation.@ICOSociety @CCardiacON @UHN @UofT

[Jason Fish @FishLab_UHN]

Excited to share our paper https://t.co/qDpeJLoyUg. Together with @dineshpmcc1 and led by Dakota Gustafson and Priya Mistry, we show that elevated levels of inflammatory and endothelial activation biomarkers before treatment can predict cancer therapy-related cardiac dysfunction.

[Stephanie Protze @StephIrisPro]

So excited to share the first paper from the lab!
We identified CD34 as a marker of the heart’s SAN pacemaker cells enabling their isolation from stem cell differentiation cultures, advancing future disease modeling and biological pacemaker applications.
https://t.co/yaThtPS3WC

[UHN STEM Pathways @UHNSTEMPathways]

We're back with another PA Day at UHN! We have two exciting sessions today with students from schools across the GTA coming in to explore #STEM. Stay tuned for some fun snapshots. 💡

[Banting & Best Diabetes Centre @BBDC_UofT]

On #WorldDiabetesDay we celebrate the next generation of diabetes researchers - like Cori Lau from @FishLab_UHN. Cori shares why diabetes research matters to him. #WDD2024

[Banting & Best Diabetes Centre @BBDC_UofT]

Our next Trainee Lab Seminar Series will take place in-person on  Friday, Nov. 15 at 12 p.m. at the Toronto General Hospital. Members from Drs. @TonyKTLam, @FishLab_UHN and Laura Chiavaroli labs will present their latest research. Learn more & register. https://t.co/smPdiFDYbi

[Milica Radisic @milicaruoft]

#exosomes from cardiomyocytes hurt and from endothelial cells aid vascularization
Endothelial extracellular vesicles enhance vascular self-assembly in engineered human cardiac tissues https://t.co/RafkvGARtg via @Biofabrication

[Canadian Cardiac Oncology Network @CCardiacON]

Don’t miss our next CCON Webinar on Nov 8th at 12pm EST! We will hear from Drs. Dinesh Thavendiranathan (@dineshpmcc1) & Ian Paterson (@HeartInstitute) about the role of cardiac MRI in cardio-oncology 🫀🩺

Register here: https://t.co/VF9ydBeCbk

[Jason Fish @FishLab_UHN]

@kat_howe @TGHRI_UHN @UHN_Research @UofTVascular @UHN_Surgery Congrats to Mandy on winning a poster award!

[Heather Ross @hearthealthydoc]

⛰️ #TestYourLimits is gearing up for another expedition...and it's a BIG one! In 2023, we reached new heights in Ecuador, overcoming obstacles & celebrating team wins. This Nov. we have something extra special in store. Can you guess where we're going? ➡️ https://t.co/Msh1HBF9DP

[Nazish Sayed MD, MS, PhD @Nazish_Sayed]

Our paper on endothelial - cardiomyocyte crosstalk in #LongCovid is now online @NatureCVR. It highlighting the importance of early vascular health monitoring in patients with #LongCovid. @iDilipThomas @StanfordCVI @StanfordSurgery @maryhawn @StanfordVasc
https://t.co/qMgobp46hA

[AHA Science @AHAScience]

This AHA scientific statement discusses the pathogenic mechanisms that link three prevalent cardiac diseases of adults:

➡️Heart failure
➡️Atrial fibrillation
➡️Coronary heart disease

These are three disorders that can lead to cognitive impairment and poor brain health.

[Jason Fish @FishLab_UHN]

What a huge accomplishment! Congrats, Priya.

[Priya Mistry @mistrypri]

Truly humbled and honoured to be awarded CIHR Vanier Scholarship! Feeling immensely grateful to all those who have guided and supported me in this journey and to be working on this important project in Dr. Jason Fish's lab! A huge thanks to everyone that supported my application!

[Ariane Marelli @DrArianeMarelli]

Congratulations to Dr. Jason Fish for winning the 2024 Mid-Career Excellence Award in Blood and Blood Vessel Research!

Dr. Fish’s background in gene regulation of blood vessels came together beautifully as he delivered his lecture entitled “Oncogenic signaling in the endothelium drives arteriovenous malformations” presented at the Canadian Lipid & Vascular Summit.

Thank you to the Canadian Society of Atherosclerosis, Thrombosis and Vascular Biology for their continued partnership with the Institute of Circulatory and Respiratory Health of the Canadian Institutes of Health Research @CIHR_IRSC.