Steven Botts

PhD | Endothelial dysfunction in vascular disease @UHN • MD Student @UofTMedicine • 🐱☕🚴🏋️🇨🇦

[Steven Botts @SRBotts]

#EndothelialDysfunction is a critical driver of #atherosclerosis, but how can EC identity be preserved to limit plaque progression?

Thrilled to share my final PhD work in @NatureComms: https://t.co/9c3bzPaUx0

@kat_howe @FishLab_UHN @PMunkCardiacCtr @UHN_Research @UofTVascular

[U of T Department of Surgery @UofTSurgery]

👏Congratulations to Dr. Giuseppe Papia on being named president-elect of the Canadian Society for Vascular Surgery (CSVS); a tremendous honour reflecting the respect & confidence of the national vascular surgery community. His term as president will begin in Oct 2027.

[UHN Research @UHN_Research]

(1/2) Congratulations to Drs. Mamatha Bhat and @kat_howe, inaugural recipients of the SUMO–UHN Distinguished Physician Investigator Award. 🎉

🔗 Read more: https://t.co/NLv9g5pZsj

[UHN Research @UHN_Research]

New research from @UHN’s @PMunkCardiacCtr shows that the protein ERG helps protect blood vessels from changes that drive atherosclerosis—the buildup of plaque in the arteries. Findings could point to future therapeutic strategies to protect arteries.

🔗: https://t.co/bDjVFgD5AX

[Kathryn Howe @kat_howe]

Reposting - our new story - now available for all! Open access. https://t.co/S1laxKMlUv Thank you @NatureComms for the incredible editorial work and review process. Hard work that led to a transformative paper! Congrats team @SRBotts @kat_howe @FishLab_UHN

[Steven Botts @SRBotts]

@CoreyScipione @Kristen_ESchulz @SnehaRajuMD @Kamalben_Prajap @chanelekpolenz @clintomics @MyronCybulsky @uoftmedicine @uoftmdphd @UofTSurgery ERG preserves endothelial identity to limit atherosclerosis:

Full paper out now in @NatureComms !!

https://t.co/qIVWa0t11K

[Steven Botts @SRBotts]

#EndothelialDysfunction is a critical driver of #atherosclerosis, but how can EC identity be preserved to limit plaque progression?

Thrilled to share my final PhD work in @NatureComms: https://t.co/9c3bzPaUx0

@kat_howe @FishLab_UHN @PMunkCardiacCtr @UHN_Research @UofTVascular

[Steven Botts @SRBotts]

Our heartfelt thanks to colleagues who helped make this work possible:

@CoreyScipione @Kristen_ESchulz @SnehaRajuMD @Kamalben_Prajap @chanelekpolenz @clintomics @MyronCybulsky @uoftmedicine @uoftmdphd @UofTSurgery

Figures adapted from our Nature Communications paper.

[Endothelial Cell News @endothelialnews]

A new study in @NatureComms, led by @UHN collaborators including Drs. @kat_howe and Jason Fish investigate the role of the ETS transcription factor ERG, a key regulator of #endothelial identity, in atheroprogression. 🧫 https://t.co/GFaPONJzcq

They identify ERG as an enforcer of endothelial function that restricts 🚫 endothelial‑to‑mesenchymal transition to limit atherosclerosis.

[Lior Pachter @lpachter]

This football match is like watching somebody tweak their UMAP hyperparameters for 90 minutes on twitch.

[Steven Botts @SRBotts]

@KevinDMangum @NatureComms @kat_howe @FishLab_UHN @PMunkCardiacCtr @UHN_Research @UofTVascular Thank you very much!

[Steven Botts @SRBotts]

@UHN_Research @NatureComms @kat_howe @FishLab_UHN @PMunkCardiacCtr @UofTVascular Thank you! Very grateful to contribute to the impactful work being done @UHN_Research.

[Steven Botts @SRBotts]

@CoreyScipione @kat_howe @FishLab_UHN @UHN Thanks @CoreyScipione - I wholeheartedly agree!!

[Corey A Scipione @CoreyScipione]

Congrats to @SRBotts, @kat_howe & @FishLab_UHN labs at @UHN for this work. The importance of #endothelial health/identity in #atherosclerosis cannot be understated! ERG dysregulation in #cardiovascular health in #rodents and translated to #human #aortic disease.

[Kathryn Howe @kat_howe]

Congrats!!👏🏼 Massive tour de force by an amazing team. See this incredible work 🙏