Clint Miller

Human genomicist, Assoc Prof @UVA. Deconvolving complex cardiovascular diseases using systems genetics and single-cell omics.

[Clint Miller @clintomics]

Latest news feature in @NatureBiotech on recent developments in spatial biology to unravel disease mechanisms, with insights from experts in field @aruthak @NeBanovich @AI4Pathology @PDulaiMD Jasmine Plummer, Amanda Orr etc https://t.co/ORxV2AYZ07

[ATVB: An AHA Journal @atvbahajournals]

The 9p21 risk locus — the first and most impactful CAD genetic risk factor in humans — drives VSMCs to adopt an osteochondrogenic state, promoting calcification @clintomics @valelosardo
https://t.co/CbZnzspnPh

[Valentina Lo Sardo @valelosardo]

Thrilled to share the🥇paper from the lab @atvbahajournals. Here we continue to unravel the mysteries of the 9p21.3 CAD locus showing it drives VSMC transition into an osteochondrogenic state, promoting calcification. @clintomics @UWMadisonCRB https://t.co/cmQLI8qLWO

[Athero-Express @atheroexpress]

🚀 Thrilled to announce our latest #preprint on intraplaque haemorrhage (IPH) quantification and molecular 🧬characterisation of carotid plaques using deep learning. A thread 🧵👇🏽

[Jeff Saucerman @jsauce7]

Trump's slashing of NIH indirects blocked for now in 22 states but not VA. Will the "peoples protector" Attorney General @JasonMiyaresVA stand up for Virginia researchers and doctors and their work to cure cancer, heart disease, diabetes, and more?

[Clint Miller @clintomics]

@C_Glastonbury @jkpritch Are @biorxivpreprint links still broken?

[Clint Miller @clintomics]

Huge congrats to PhD student @John_S_IV for successfully defending his thesis today! Thanks to the committee and everyone for their support. @shefflab @uva_bims @MedicineUVA

[Clint Miller @clintomics]

New model for multimodal spatial omics analysis, MISO, performs feature extraction, clustering and handles large-scale omics data. Includes extensive benchmarking and application to various cancer types. ⁦@DrMingyaoLi⁩ ⁦@naturemethods⁩ https://t.co/Zpf9eweymW

[Clint Miller @clintomics]

New expression foundation model, GET, predicts gene expression in unseen cell types and context specific TF interaction networks - pretrained on chromatin accessibility data from 213 human adult and fetal cell types. @nature @ericxing @RabadanColumbia https://t.co/d0libvGubp

[Clint Miller @clintomics]

New generative model, IMPA, predicts cell morphology responses to genetic and drug perturbations, enhancing phenotypic screening and drug discovery. Corrects batch effects and models unseen perturbations. @NatureComms @mo_lotfollahi @fabian_theis
https://t.co/qRAyIMugX7

[Clint Miller @clintomics]

R package: https://t.co/jWOs74viIi
Code: https://t.co/tnRw1053Dm
Python implementation: https://t.co/7C1RpsFvYB

[Clint Miller @clintomics]

New single-cell analysis framework, LEMUR, disentangles covariates and latent cell states from multi-condition data to predict counterfactual gene expression and identify cell neighborhoods with similar DEGs without clustering. https://t.co/Dktxxek5C7 @NatureGenet @wolfgangkhuber

[Clint Miller @clintomics]

Delineating the effective use of self-supervised learning in single-cell genomics ⁦@NatMachIntell⁩ ⁦@fabian_theis⁩ https://t.co/baaEscxdGp

[Clint Miller @clintomics]

@Linda_Kachuri @MedicineUVA Thanks Linda!

[Clint Miller @clintomics]

Very grateful and humbled to receive promotion to tenure @MedicineUVA!

Huge thanks to my supportive mentors, colleagues, family, and talented trainees who continue to inspire me along this journey.

Here’s to the work ahead!

[Clint Miller @clintomics]

@Art_Yurdagul @MedicineUVA Thanks Art!

[Clint Miller @clintomics]

@kat_howe @MedicineUVA Thank you for the kind words Kathryn!! Very fortunate to work with you and your impressive team!

[Clint Miller @clintomics]

@rcwirka @MedicineUVA Thanks Rob!

[Clint Miller @clintomics]

@HaoYin20 @MedicineUVA Thanks Hao!

[Clint Miller @clintomics]

@Jie_Immunology @MedicineUVA Thanks Jie!

[Clint Miller @clintomics]

@AnjaTrillhaase @MedicineUVA Thanks Anja!